Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?

Identification of a Nuclear Receptor for Bile Acids

1999 • 2,537 citations

Transport Between the Cell Nucleus and the Cytoplasm

1999 • 2,001 citations

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III

2000 • 867 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

1997 • 628 citations

Ran Induces Spindle Assembly by Reversing the Inhibitory Effect of Importin α on TPX2 Activity

2001 • 592 citations

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

1999 • 492 citations

Stimulation of Microtubule Aster Formation and Spindle Assembly by the Small GTPase Ran

1999 • 393 citations

Importin β Is a Mitotic Target of the Small GTPase Ran in Spindle Assembly

2001 • 374 citations

The Ran GTPase regulates mitotic spindle assembly

1999 • 349 citations

Role of Importin-β in Coupling Ran to Downstream Targets in Microtubule Assembly

2001 • 318 citations

Self-Organization of Microtubule Asters Induced in Xenopus Egg Extracts by GTP-Bound Ran

1999 • 305 citations

Morphogenetic Properties of Microtubules and Mitotic Spindle Assembly

1996 • 292 citations

GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly

2000 • 255 citations

Nuclear pores and nuclear assembly

2001 • 251 citations

RanBP1 is crucial for the release of RanGTP from importin β‐related nuclear transport factors

1997 • 250 citations

Ran–GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly

2001 • 243 citations

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

2001 • 221 citations

Chromatin-Independent Nuclear Envelope Assembly Induced by Ran GTPase in Xenopus Egg Extracts

2000 • 199 citations

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

1991 • 195 citations

The direction of transport through the nuclear pore can be inverted

1999 • 186 citations

Running on Ran

2001 • 177 citations

Dimples, pores, star-rings, and thin rings on growing nuclear envelopes: evidence for structural intermediates in nuclear pore complex assembly

1997 • 176 citations

Assembly of the nuclear pore: biochemically distinct steps revealed with NEM, GTP gamma S, and BAPTA.

1996 • 165 citations

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

1999 • 145 citations

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

1994 • 139 citations

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

1994 • 138 citations

A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.

1995 • 96 citations

Influence of M-phase chromatin on the anisotropy of microtubule asters.

1996 • 85 citations

Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo.

2000 • 79 citations

Roles of Ran–GTP and Ran–GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system

2001 • 69 citations

The Fission Yeast Ran Gtpase Is Required for Microtubule Integrity

2000 • 62 citations

The role of the Ran GTPase in nuclear assembly and DNA replication: Characterisation of the effects of Ran mutants

1998 • 56 citations

Regulation of Cdc2/cyclin B activation by Ran, a Ras-related GTPase

1995 • 51 citations

Spindles get the Ran around

2000 • 39 citations

Ran alters nuclear pore complex conformation

2000 • 38 citations

Mutations in fission yeast Cut15, an importin α homolog, lead to mitotic progression without chromosome condensation

1998 • 37 citations

The KetelD Dominant-Negative Mutations Identify Maternal Function of the Drosophila Importin-β Gene Required for Cleavage Nuclei Formation

2000 • 34 citations

Molecular cloning and characterization of a ras-related gene of ran/tc4/spi1 subfamily in Giardia lamblia.

1994 • 19 citations

Inhibition by Anti-RCC1 Monoclonal Antibodies of RCC1-Stimulated Guanine Nucleotide Exchange on Ran GTPase

1997 • 6 citations