3-Phosphoinositide-dependent Protein Kinase 1, an Akt1 Kinase, Is Involved in Dephosphorylation of Thr-308 of Akt1 in Chinese Hamster Ovary Cells

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Regulation of protein kinase cascades by protein phosphatase 2A

1999 • 798 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

1987 • 752 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

Serine/threonine protein phosphatases

1995 • 635 citations

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 • 612 citations

Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase

1995 • 612 citations

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

1996 • 490 citations

The Protein Phosphatases Involved in Cellular Regulation. 1. Classification and Substrate Specificities

1983 • 471 citations

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

1998 • 383 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

1998 • 338 citations

Inhibitors of protein kinases and phosphatases

1994 • 268 citations

INH, a negative regulator of MPF, is a form of protein phosphatase 2A

1991 • 231 citations

Intracellular signalling: PDK1 – a kinase at the hub of things

1999 • 221 citations

Overexpression of Catalytic Subunit p110α of Phosphatidylinositol 3-Kinase Increases Glucose Transport Activity with Translocation of Glucose Transporters in 3T3-L1 Adipocytes

1996 • 194 citations

Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.

1993 • 173 citations

Dephosphorylation of Cdk2 Thr ¹⁶⁰ by the Cyclin-Dependent Kinase-Interacting Phosphatase KAP in the Absence of Cyclin

1995 • 170 citations

Activation of Ca2+/Calmodulin-dependent Protein Kinase (CaM-kinase) IV by CaM-kinase Kinase in Jurkat T Lymphocytes

1995 • 111 citations

Distinct Roles for PP1 and PP2A in Phosphorylation of the Retinoblastoma Protein

1999 • 106 citations

Osmotic Shock Inhibits Insulin Signaling by Maintaining Akt/Protein Kinase B in an Inactive Dephosphorylated State

1999 • 106 citations

Primary Structure, Tissue Distribution, and Expression of Mouse Phosphoinositide-dependent Protein Kinase-1, a Protein Kinase That Phosphorylates and Activates Protein Kinase Cζ

1999 • 92 citations

Regulation of protein phosphatase 1 and 2A activities by insulin during myogenesis in rat skeletal muscle cells in culture.

1994 • 86 citations

A Novel Isoform of Syntaxin-binding Protein Homologous to Yeast Sec1 Expressed Ubiquitously in Mammalian Cells

1995 • 85 citations

Stimulation of Protein Phosphatase-1 Activity by Insulin in Rat Adipocytes

1995 • 51 citations

Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain. II. Enzymatic characteristics and regulation of activities by phosphorylation and dephosphorylation.

1992 • 50 citations

Rat Brain Protein Phosphatase 2A: An Enzyme that May Regulate Autophosphorylated Protein Kinases

1995 • 40 citations

Signalling via phosphoinositide 30H kinases

1997 • 33 citations

Protein phosphatase-1 and -2a activities in cultured fetal chick neurons: differential regulation by insulin and insulin-like growth factor-I.

1993 • 19 citations