The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Regulation of surface and intracellular expression of CTLA4 on mouse T cells.

1996 • 340 citations

X-linked lymphoreticular disease in the scurfy (sf) mutant mouse.

1991 • 339 citations

Cellular and molecular characterization of the scurfy mouse mutant.

1999 • 197 citations

CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.

1997 • 187 citations

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education.

1991 • 175 citations

Cellular and Molecular Characterization of thescurfyMouse Mutant

1999 • 160 citations

Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor‐transgenic CTLA‐4‐deficient mice

1997 • 74 citations

Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3–mediated Depletion of Thymocytes

1998 • 57 citations

Functional differentiation of T cells in the intestine of T cell receptor transgenic mice

1997 • 51 citations

The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3 on the proximal X Chromosome

1994 • 24 citations

Developmental study of hepatic glutamine synthetase in a mouse model of congenital hyperammonemia

1997 • 6 citations

Superantigens and conventional antigens induce different responses in alpha beta T-cell receptor transgenic mice.

1995 • 5 citations

Two-dimensional polyacrylamide gel electrophoretic characterization of proteins from organs of C3H mice expressing the scurfy (sf) genetic mutation during early and late stages of disease progression.

1992 • 1 citations