An adrenal-mediated, naloxone-reversible increase in reaction time in the tail-flick test following intrathecal administration of substance p at the lower thoracic spinal level in the rat

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

1978 • 1,426 citations

Fundamentals of experimental design.

1980 • 780 citations

Enkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medulla

1978 • 554 citations

Opiate-like materials in the adrenal medulla: evidence for storage and secretion with catecholamines.

1979 • 492 citations

Spinal noradrenergic terminal system mediates antinociception

1980 • 317 citations

Co-release of enkephalin and catecholamines from cultured adrenal chromaffin cells

1981 • 301 citations

Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability

1985 • 297 citations

Multiple opioid systems and pain

1986 • 286 citations

CNS effects of peripherally administered brain peptides

1979 • 278 citations

Entry of Opioid Peptides into the Central Nervous System

1980 • 247 citations

The use of quaternary narcotic antagonists in opiate research

1985 • 244 citations

Blood-Brain Barrier Restriction of Peptides and the Low Uptake of Enkephalins*

1978 • 225 citations

Met-enkephalin circulates in human plasma

1980 • 217 citations

The differential distribution and relationship of serotoninergic and peptidergic fibers to sympathoadrenal neurons in the intermediolateral cell column of the rat: A combined retrograde axonal transport and immunofluorescence study

1982 • 204 citations

Depressant actions of methionine-enkephalin and somatostatin in cat dorsal horn neurones activated by noxious stimuli

1978 • 200 citations

Substance P neurons project from the ventral medulla to the intermediolateral cell column and ventral horn in the rat

1982 • 199 citations

Effects of Morphine and Naloxone on Dorsal Horn Neurones in the Cat

1974 • 143 citations

Substance P reduces tail-flick latency: Implications for chronic pain syndromes

1982 • 137 citations

Permeability of the blood-brain barrier to neuropeptides: The case for penetration

1985 • 124 citations

Effects of substance P and thyrotropin-releasing hormone on sympathetic preganglionic neurones in the upper thoracic intermediolateral nucleus of the cat

1984 • 123 citations

Peripheral antinociceptive effects of N-methyl morphine

1982 • 112 citations

Adrenal medullary tissue transplants in the rat spinal cord reduce pain sensitivity

1986 • 109 citations

Enkephalin and Blood-Brain Barrier: Studies of Binding and Degradation in Isolated Brain Micro vessels*

1981 • 106 citations

Analgesia induced by isolated bovine chromaffin cells implanted in rat spinal cord.

1986 • 98 citations

beta-Endorphin: stability, clearance behavior, and entry into the central nervous system after intravenous injection of the tritiated peptide in rats and rabbits.

1980 • 98 citations

The direct and specific opiate-like effect of Met5-enkephalin and analogues on the spinal cord

1977 • 90 citations

Effects of substance P on sympathetic preganglionic neurones

1983 • 90 citations

Release of enkephalins and enkephalin-containing polypeptides from perfused beef adrenal glands.

1980 • 87 citations

Opioid hexapeptides and heptapeptides in adrenal medulla and brain possible implications on the biosynthesis of enkephalins

1980 • 87 citations

Comparison of the effects of substance P, neurokinin A, physalaemin and eledoisin in facilitating a nociceptive reflex in the rat

1986 • 82 citations

Biochemical characterization of enkephalin-like immunoreactive peptides of adrenal glands

1980 • 80 citations

Substance P immunoreactivity released from rat spinal cord after kainic acid excitation of the ventral medulla oblongata: a correlation with increases in blood pressure

1984 • 74 citations

Antinociceptive effects of intrathecally administered human β-endorphin in the rat and cat

1978 • 72 citations

Enkephalin in bovine adrenal gland: Multiple molecular forms of [met5]-enkephalin immunoreactive peptides

1980 • 70 citations

Naloxone excites nociceptive units in the lumbar dorsal horn of the spinal cat

1979 • 68 citations

Morphine Blockade of Amino Acid Putative Transmitters on Cat Spinal Cord Sensory Interneurones

1973 • 66 citations

Substance P-induced release of Met5-Enkephalin from striatal and periaqueductal gray slices

1983 • 63 citations

Peripheral opiate receptor mechanisms

1981 • 58 citations

Coexistence of serotonin- and substance P-like immunoreactivity in nerve fibers apposing identified sympathoadrenal preganglionic neurons in rat intermediolateral cell column

1986 • 56 citations

Substance P given intrathecally at the spinal T9 level increases adrenal output of adrenaline and noradrenaline in the rat

1985 • 56 citations

Endorphins mediate overshoot of substance P-induced facilitation of a spinal nociceptive reflex

1983 • 56 citations

Localization of enkephalins in adrenaline cells and the nerves innervating adrenaline cells in rat adrenal medulla

1985 • 53 citations

In vivo comparison of the receptor populations acted upon in the spinal cord by morphine and pentapeptides in the production of analgesia

1978 • 49 citations

RADIOIMMUNOASSAY OF LEUCINE-ENKEPHALIN-LIKE SUBSTANCE IN HUMAN AND CANINE PLASMA

1981 • 48 citations

In vivo characterization of the mechanisms that secrete enkephalin-like peptides stored in dog adrenal medulla

1981 • 46 citations

Distribution of label after intrathecal administration of 125I-substance P in the rat

1987 • 45 citations

Substance p anatogue blocks sp-induced facilitation of a spinal nociceptive reflex

1984 • 45 citations

Adrenal release of catecholamines and Met-enkephalin before and after stress as measured by a novel in vivo dialysis method in the rat

1985 • 44 citations

Dynorphin and enkephalins in adrenal paraneurones. Opiates in the adrenal medulla

1984 • 42 citations

Substance P given intrathecally at the spinal T9 level increases arterial pressure and heart rate in the rat

1987 • 41 citations

Lipotropin, Melanotropin and Endorphin: In Vivo Catabolism and Entry into Cerebrospinal Fluid

1978 • 40 citations

Analgesic activity and release of [Met5]enkephalin-Arg6-Gly7-Leu8 from rat spinal cord in vivo

1986 • 40 citations

Low permeation of systemically administered human ß-endorphin into rabbit brain measured by radioimmunoassays differentiating human and rabbit ß-endorphin

1980 • 37 citations

Co-release of enkephalins and precursors with catecholamines by the perfused cat adrenal in-situ

1983 • 27 citations

Design for an inexoensive unit for measuring tail flick latencies

1981 • 25 citations

Actions of narcotic analgesics and antagonists on spinal units responding to natural stimulation in the cat

1979 • 25 citations

The effects of intrathecal administration of arginine-vasopressin and substance P on blood pressure and adrenal secretion of epinephrine in rats

1986 • 21 citations

Diurnal variation in excitation of dorsal horn units by naloxone in the spinal cat suggests a circulating opioid factor

1981 • 19 citations

Pro-enkephalin peptides possessing Met-enkephalin-Arg6-Gly7-Leu8-immunoreactivity in rat CSF, striatum and adrenal gland

1985 • 15 citations

Adrenomedullary ornithine decar☐ylase activity: Its use in biochemical mapping of the origins of the splanchnic nerve in the rat

1982 • 14 citations

Antagonism of stress-induced analgesia by quaternary naloxone

1986 • 10 citations

Adrenal-mediated depression of a spinal nociceptive reflex by intrathecal administration of substance p to the eighth thoracic segment in the rat

1987 • 1 citations