Permeability of the blood-brain barrier to neuropeptides: The case for penetration

Structure and function of the blood–brain barrier

2009 • 4,310 citations

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1971 • 1,671 citations

An unidentified depressor substance in certain tissue extracts

1931 • 1,565 citations

Peptidergic neurones

1980 • 1,523 citations

Growth Hormone-Releasing Factor from a Human Pancreatic Tumor That Caused Acromegaly

1982 • 1,263 citations

Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour

1982 • 1,092 citations

Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog.

1978 • 805 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

New peptide in the vertebrate CNS reacting with antigastrin antibodies

1975 • 749 citations

Intraneuronal Aluminum Accumulation in Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia of Guam

1982 • 678 citations

Physiology of the cerebro-spinal fluid

1967 • 622 citations

Brain Peptides as Neurotransmitters

1980 • 486 citations

Neurosecretion and Brain Peptides

1982 • 458 citations

Endogenous Peptides and Learning and Memory Processes

1981 • 454 citations

Cholecystokinin Receptors in the Brain: Characterization and Distribution

1980 • 432 citations

Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brain

1978 • 426 citations

Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF

1983 • 343 citations

Aspects of Hypothalamic Regulation of the Pituitary Gland

1978 • 314 citations

Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability

1985 • 297 citations

CNS effects of peripherally administered brain peptides

1979 • 278 citations

Frontiers in Neuroendocrinology

1974 • 270 citations

Peptides and the blood–brain barrier

2015 • 250 citations

Entry of Opioid Peptides into the Central Nervous System

1980 • 247 citations

Evidence for the Release of Vasopressin and Oxytocin into Cerebrospinal Fluid: Measurements in Plasma and CSF of Intact and Hypophysectomized Rats

1977 • 244 citations

Evidence for Blood‐Brain Barrier Changes in Senile Dementia of the Alzheimer Type (SDAT)

1982 • 230 citations

Intranuclear aluminum content in Alzheimer's disease, dialysis encephalopathy, and experimental aluminum encephalopathy

1980 • 229 citations

Cerebral microcirculation and metabolism

1982 • 227 citations

Blood-Brain Barrier Restriction of Peptides and the Low Uptake of Enkephalins*

1978 • 225 citations

Rapid appearance of intraventricularly administered neuropeptides in the peripheral circulation

1982 • 224 citations

Relationship between plasma and cerebrospinal fluid insulin levels of dogs.

1977 • 216 citations

Peptides in brain and intestine

1976 • 215 citations

Methods for quantifying the transport of drugs across brain barrier systems

1981 • 214 citations

Penetration of 14C-inulin and 14C-sucrose into brain, cerebrospinal fluid, and skeletal muscle of developing rats

1969 • 186 citations

Vasopressin in cerebrospinal fluid and plasma of man, dog, and rat.

1978 • 156 citations

Catecholamines

1972 • 149 citations

Differential Clearance of Neurophysin and Neurohypophysial Peptides from the Cerebrospinal Fluid in Conscious Guinea Pigs

1982 • 146 citations

A daily vasopressin rhythm in rat cerebrospinal fluid

1983 • 139 citations

Brain Peptides

1981 • 138 citations

Behavioral effects of bombesin administration in rats

1982 • 124 citations

Albumin and immunoglobulin in plasma and cerebrospinal fluid, and blood-cerebrospinal fluid barrier function in patients with dementia of alzheimer type and multi-infarct dementia

1983 • 121 citations

Immunoreactive ACTH in Cerebrospinal Fluid¹

1974 • 121 citations

The satiety effect of cholecystokinin: A progress report

1981 • 119 citations

A Time-Dependent Peak of Oxytocin Exists in Cerebrospinal Fluid but Not in Plasma of Humans

1983 • 117 citations

Insulin increases glucose transfer across the blood-brain barrier in man.

1981 • 113 citations

Distribution of 3H-α-MSH in rat brain

1976 • 110 citations

ALUMINIUM INCREASES PERMEABILITY OF THE BLOOD-BRAIN BARRIER TO LABELLED DSIP AND β-ENDORPHIN: POSSIBLE IMPLICATIONS FOR SENILE AND DIALYSIS DEMENTIA

1983 • 110 citations

Distributed model for drug delivery to CSF and brain tissue

1983 • 105 citations

The Dialysis Dementia Syndrome and Aluminum Intoxication

1982 • 105 citations

The Clinical Biochemistry of Aluminum

1981 • 104 citations

Oxytocin, Vasopressin, and Estrogen-Stimulated Neurophysin: Daily Patterns of Concentration in Cerebrospinal Fluid

1982 • 103 citations

Brain peptides — A new endocrinology

1980 • 102 citations

beta-Endorphin: stability, clearance behavior, and entry into the central nervous system after intravenous injection of the tritiated peptide in rats and rabbits.

1980 • 98 citations

EFFECTS OF ALUMINUM SALTS ON CULTURED NEUROBLASTOMA CELLS

1974 • 97 citations

Vasopressin in Human Cerebrospinal Fluid*

1980 • 94 citations

Aluminum and Alzheimerʼs Disease

1983 • 92 citations

Research Methods in Neurochemistry

1972 • 90 citations

Cholecystokinin acts on the hypothalamic “noradrenergic system” involved in feeding

1980 • 89 citations

Alzheimer's disease : early recognition of potentially reversible deficits

1979 • 86 citations

Delta-sleep-inducing peptide (DSIP): A review

1984 • 86 citations

Brain Peptides

1981 • 86 citations

Additional evidence that small amounts of a peptide can cross the blood-brain barrier

1979 • 82 citations

Immunoreactive β-Endorphin in Human Cerebrospinal Fluid*

1980 • 80 citations

Vasoactive intestinal polypeptide (VIP) in human cerebrospinal fluid

1977 • 78 citations

A brain-to-blood carrier-mediated transport system for small, N-Tyrosinated peptides

1984 • 77 citations

Oxytocin and Neurophysin in Plasma and CSF during Suckling in the Guinea-Pig

1982 • 72 citations

Learning deficit in immature rabbits with aluminum-induced neurofibrillary changes

1982 • 72 citations

Relationships between α-MSH levels in blood and in cerebrospinal fluid

1980 • 62 citations

Aluminum alters the permeability of the blood-brain barrier to some non-peptides

1985 • 61 citations

Evidence that [125I]N-Tyr-delta sleep-inducing peptide crosses the blood-brain barrier by a non-competitive mechanism

1984 • 61 citations

Exchange of Albumin Between Plasma and Cerebrospinal Fluid

1953 • 59 citations

Albumin Exchange Between Plasma and Cerebrospinal Fluid

1967 • 58 citations

Medical Therapies for Mood Disorders Alter the Blood-Brain Barrier

1981 • 56 citations

An enzymatically stable peptide with activity in the central nervous system: Its penetration through the blood-CSF barrier

1977 • 55 citations

Evidence for a cholecystokinin gut-brain axis with modulation by bombesin

1980 • 55 citations

Cerebrospinal Fluid Vasopressin and Vasotocin in Health and Disease

1980 • 53 citations

Permeability of blood-brain barrier to DSIP peptides

1981 • 52 citations

THE ENZYME HISTOCHEMISTRY OF THE CHOROID PLEXUS

1983 • 52 citations

Immunoreactive Calcitonin in Human Cerebrospinal Fluid∗*

1980 • 51 citations

Delta sleep-inducing peptide crosses the blood-brain-barrier in dogs: Some correlations with protein binding

1982 • 51 citations

Relations between neuropeptides and gut hormones

1980 • 50 citations

Vasopressin in blood and third ventricle CSF during dehydration, thirst, and hemorrhage

1983 • 50 citations

Changes in cerebrospinal fluid and plasma vasopressin in the febrile sheep

1983 • 49 citations

Dissociation of Plasma and Cerebrospinal Fluid Beta-Endorphin-like Immunoactivity Levels during Pregnancy and Parturition

1982 • 49 citations

Neurobiology of Cerebrospinal Fluid 1

1982 • 47 citations

Senile dementia and Alzheimer's disease: A current view

1980 • 46 citations

Neuropeptides and the blood-brain barrier.

1981 • 45 citations

Persistence of β-Endorphin in Human Cerebrospinal Fluid after Hypophysectomy*

1983 • 44 citations

Circulation of cerebrospinal fluid in the spinal region of the cat

1962 • 44 citations

Neurobiology of Cerebrospinal Fluid: 1

1981 • 43 citations

Differential penetration of DSIP peptides into rat brain

1982 • 42 citations

Endogenous opiates: 1980

1981 • 41 citations

Morphofunctional Aspects of the Normal and Pathological Blood-Brain Barrier

1983 • 41 citations

Immunoreactive calcitonin in cerebrospinal fluid of man

1980 • 40 citations

Lipotropin, Melanotropin and Endorphin: In Vivo Catabolism and Entry into Cerebrospinal Fluid

1978 • 40 citations

Brain peptides: The dangers of constricted nomenclatures

1983 • 39 citations

Low permeation of systemically administered human ß-endorphin into rabbit brain measured by radioimmunoassays differentiating human and rabbit ß-endorphin

1980 • 37 citations

Repeated systemic aluminum exposure effects on classical conditioning of the rabbit.

1983 • 36 citations

Effects of DSIP in Man

1983 • 35 citations

Clearance of Vasopressin from Cerebrospinal Fluid to Blood in Chronically Cannulated Brattleboro Rats

1983 • 35 citations

Possible Role of Insulin in the Transport of Tyrosine and Tryptophan from Blood to Brain

1976 • 35 citations

Vasopressin in the cerebrospinal fluid of patients with normal pressure hydrocephalus and benign intracranial hypertension

1982 • 35 citations

Cholinergic Function in Lumbar Aluminum Myelopathy

1983 • 32 citations

Vasopressin in blood and third ventricle CSF of dogs in chronic experiments

1983 • 31 citations

Calcitonin in Plasma and Cerebrospinal Fluid from Normal Subjects and Patients with Medullary Thyroid Carcinoma: Possible Restriction of Calcitonin by the Blood-Brain Barrier*

1982 • 31 citations

CENTRAL MECHANISM OF VASOPRESSIN‐INDUCED CHANGES IN ANTIDIURETIC HORMONE RELEASE

1977 • 30 citations

The Anterior Pituitary Gland

1984 • 29 citations

Selective effects of α-MSH and MIF-1 on the blood-brain barrier

1981 • 29 citations

The aluminum-induced increase in blood-brain barrier permeability to delta-sleep-inducing peptide occurs throughout the brain and is independent of phosphorus and acetylcholinesterase levels

1985 • 29 citations

An analog of ACTH/MSH4−9, ORG-2766, reduces permeability of the blood-brain barrier

1981 • 27 citations

Multiple Independent Actions of Neuropeptides on Behavior

1981 • 23 citations

Gastrin in human cerebrospinal fluid: lack of correlation with serum concentrations

1979 • 23 citations

CSF-plasma relationships for DSIP and some other neuropeptides

1983 • 21 citations

The accumulation of (3H) enkephalinamide (2-D-alanine-5-methioninamide) in rat brain tissues

1978 • 21 citations

The Brohée lecture 1982. Gastrointestinal hormones: a field of increasing complexity.

1982 • 21 citations

Melanotropic peptides increase permeability of plasma/cerebrospinal fluid barrier.

1978 • 19 citations

Hypophyseal Hormone Levels in Blood and Cerebrospinal Fluid in Response to Histamine and Pentylenetetrazol

1982 • 19 citations

Regulation of angiotensinogen in cerebrospinal fluid and plasma of rats

1983 • 17 citations

Neurochemical Study of the Cerebrospinal Fluid

1978 • 17 citations

Impermeability of the Rat Blood-Brain Barrier to Exogenously Administered Gonadotropin-Releasing Hormone

1983 • 14 citations

Passage of Proteins from Blood to Cerebrospinal Fluid Model for Transfer by Pores and Vesicles

1983 • 13 citations

Influence of histamine and pentobarbitone on plasma and CSF vasopressin levels of hypophysectomized rats

1982 • 13 citations

Aluminum as a cause of senile dementia.

1982 • 12 citations

Choroid-Plexus Transport of Enkephalins and Other Neuropeptides

1983 • 11 citations

The appearance of endogenous opiates in cerebrospinal fluid following opiate injection in various animal species

1982 • 10 citations

Limitations to effect of α-MSH on permeability of blood-brain barrier to IV 99mTc-pertechnetate

1982 • 8 citations

Soluble brain proteins in dialysis encephalopathy

1980 • 4 citations

Mediation of Angiotensin-Induced Drinking Behavior by the Circumventricular Organs

2015 • 4 citations