The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

A rapid, sensitive, and specific method for the determination of protein in dilute solution

1973 • 2,518 citations

[51] Assays for differentiation of glutathione S-Transferases

1981 • 2,259 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

[28] Glutathione transferase (human placenta)

1981 • 658 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

STRUCTURE AND FUNCTION OF SIGNAL-TRANSDUCING GTP-BINDING PROTEINS

1991 • 630 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Purification of glutathione S-transferases from human liver by glutathione-affinity chromatography

1977 • 481 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

CONSTRAINED PEPTIDES: MODELS OF BIOACTIVE PEPTIDES AND PROTEIN SUBSTRUCTURES

1992 • 360 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

1993 • 276 citations

Protein kinase C contains two phorbol ester binding domains.

1991 • 234 citations

The nature of protein kinase C activation by physically defined phospholipid vesicles and diacylglycerols.

1985 • 228 citations

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.

1992 • 219 citations

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

1993 • 189 citations

GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.

1993 • 180 citations

Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene

1990 • 174 citations

The regulatory domain of protein kinase C coordinates four atoms of zinc.

1992 • 129 citations

Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine.

1986 • 127 citations

Purification, cDNA‐cloning and expression of human diacylglycerol kinase

1990 • 124 citations

A phorbol ester binding domain of protein kinase C gamma. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide.

1994 • 105 citations

Identification of two cytotoxic T lymphocyte-recognized epitopes in the Ras protein.

1993 • 83 citations

Cognitive kinases.

1993 • 82 citations

A phorbol ester binding domain of protein kinase C gamma. High affinity binding to a glutathione-S-transferase/Cys2 fusion protein.

1994 • 77 citations

Selective activation of Ca(2+)-activated PKCs in Aplysia neurons by 5- HT

1992 • 72 citations

Insulin and platelet-derived growth factor stimulate phosphorylation of the c-raf product at serine and threonine residues in intact cells.

1991 • 48 citations

Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line.

1993 • 40 citations

A protein histidine kinase induced m rat liver by peroxisome proliferators

1993 • 34 citations

Analysis of the sequence and embryonic expression of chicken neurofibromin mRNA

1993 • 10 citations

Protein Kinase C, a Zinc Metalloprotein: Quantitation of Zinc by Atomic Absorption Spectrometry

1993 • 4 citations