Cloning of 559 potential exons of genes of human chromosome 21 by exon trapping.

Basic local alignment search tool

1990 • 87,358 citations

Basic Local Alignment Search Tool

1990 • 12,947 citations

Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

1986 • 1,702 citations

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries

1988 • 1,171 citations

Exon amplification: a strategy to isolate mammalian genes based on RNA splicing.

1991 • 425 citations

Construction and characterization of a normalized cDNA library.

1994 • 411 citations

Continuum of overlapping clones spanning the entire human chromosome 21q

1992 • 393 citations

Complete DNA sequence of yeast chromosome XI

1994 • 377 citations

A New Five-Year Plan for the U.S. Human Genome Project

1993 • 317 citations

How many genes in the human genome?

1994 • 298 citations

Isolation of genes from complex sources of mammalian genomic DNA using exon amplification

1994 • 276 citations

Direct selection: a method for the isolation of cDNAs encoded by large genomic regions.

1991 • 271 citations

Human Genome Project

1993 • 228 citations

cDNA selection: efficient PCR approach for the selection of cDNAs encoded in large chromosomal DNA fragments.

1991 • 211 citations

Correlations between isochores and chromosomal bands in the human genome.

1993 • 152 citations

Molecular cloning and sequence analysis of human genomic DNA encoding A novel membrane protein which exhibits a slowly activating potassium channel activity

1989 • 142 citations

The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21

1995 • 128 citations

cDNA Cloning of Transcription Factor E4TF1 Subunits with Ets and Notch Motifs

1993 • 99 citations

Improved sensitivity of biological sequence database searches

1990 • 96 citations

Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain.

1994 • 75 citations

Human chromosome 21: genome mapping and exploration, circa 1993

1993 • 72 citations

A Notl restriction map of the entire long arm of human chromosome 21

1993 • 72 citations

Isolation and Mapping of Human Chromosome 21 cDNA: Progress in Constructing a Chromosome 21 Expression Map

1994 • 71 citations

An integrated YAC-overlap and ‘cosmid-pocket’ map of the human chromosome 21

1994 • 70 citations

Model for a transcript map of human chromosome 21: isolation of new coding sequences from exon and enriched cDNA libraries

1995 • 68 citations

A Linkage Map of Human Chromosome 21: 43 PCR Markers at Average Intervals of 2.5 cM

1993 • 62 citations

A transcript map of the Down syndrome critical region on chromosome 21

1994 • 51 citations

Cosmid assembly and anchoring to human chromosome 21

1995 • 46 citations

Efficient selection of 3′-terminal exons from vertebrate DNA

1993 • 43 citations

CDNA selection from 10 Mb of Chromosome 21 DNA: efficiency in transcriptional mapping and reflections of genome organization

1995 • 40 citations

Localization of 102 exons to a 2.5 Mb region involved in Down syndrome

1995 • 40 citations

The Primary Structure of Human Liver Type Phosphofructokinase and Its Comparison with Other Types of PFK

1989 • 40 citations

The structure of the human liver-type phosphofructokinase gene

1990 • 34 citations

Identification of human chromosome 9 specific genes using exon amplification

1993 • 28 citations

Physical mapping of chromosome 21.

1993 • 26 citations

A Search for Genes from the Dark Band Regions of Human Chromosome 21

1995 • 26 citations

Cloning of the cDNA for the Human ATP Synthase OSCP Subunit (ATP50) by Exon Trapping and Mapping to Chromosome 21q22.1-q22.2

1995 • 22 citations

Analysis of chromosome 21 yeast artificial chromosome (YAC) clones.

1992 • 21 citations

COMMENTARY: So many needles, so much hay

1995 • 10 citations

Mapping of the Human Transcription Factor GABPA (E4TF1-60) Gene to Chromosome 21

1995 • 8 citations