Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries

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1983 • 27,328 citations

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1979 • 3,679 citations

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1986 • 3,284 citations

Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization.

1986 • 3,231 citations

Repeated Sequences in DNA

1968 • 2,836 citations

Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes.

1981 • 1,165 citations

An evaluation of confocal versus conventional imaging of biological structures by fluorescence light microscopy.

1987 • 850 citations

Fading of immunofluorescence during microscopy: a study of the phenomenon and its remedy

1982 • 822 citations

A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.

1982 • 759 citations

Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes

1983 • 707 citations

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes

1988 • 563 citations

Cloning of human satellite III DNA: different components are on different chromosomes

1979 • 470 citations

Three-dimensional architecture of a polytene nucleus

1983 • 453 citations

Confocal scanning light microscopy with high aperture immersion lenses

1979 • 410 citations

Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84

1986 • 380 citations

Removal of repeated sequences from hybridisation probes

1985 • 293 citations

Cytogenetic Analysis by In Situ Hybridization with Fluorescently Labeled Nucleic Acid Probes

1986 • 287 citations

Reproducible compartmentalization of individual chromosome domains in human CNS cells revealed by in situ hybridization and three-dimensional reconstruction

1988 • 279 citations

Individual interphase chromosome domains revealed by in situ hybridization

1985 • 274 citations

Rabl's model of the interphase chromosome arrangement tested in Chinise hamster cells by premature chromosome condensation and laser-UV-microbeam experiments

1982 • 271 citations

Genomic Organization of Alpha Satellite DNA on Human Chromosome 7: Evidence for Two Distinct Alphoid Domains on a Single Chromosome

1987 • 231 citations

Specific staining of human chromosomes in Chinese hamster x man hybrid cell lines demonstrates interphase chromosome territories

1985 • 231 citations

Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization

1987 • 220 citations

DNA Content and DNA-Based Centromeric Index of the 24 Human Chromosomes

1973 • 207 citations

Different central nervous system cell types display distinct and nonrandom arrangements of satellite DNA sequences.

1984 • 191 citations

Rapid interphase and metaphase assessment of specific chromosomal changes in neuroectodermal tumor cells by in situ hybridization with chemically modified DNA probes

1988 • 177 citations

Genomic organization of alpha satellite DNA on human chromosome 7: evidence for two distinct alphoid domains on a single chromosome.

1987 • 149 citations

Considerations on a laser-scanning-microscope with high resolution and depth of field.

1978 • 144 citations

Chromosomal and nuclear distribution of the HindIII 1.9-kb human DNA repeat segment

1984 • 143 citations

Human Chromosome–Specific DNA Libraries: Construction and Availability

1986 • 121 citations

Fluorescence in situ hybridization to interphase cell nuclei in suspension allows flow cytometric analysis of chromosome content and microscopic analysis of nuclear organization

1988 • 95 citations

Double in situ hybridization in combination with digital image analysis: A new approach to study interphase chromosome topography

1989 • 83 citations

Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes

1984 • 83 citations

Indications of Centromere Movement during Interphase and Differentiationa

1985 • 77 citations

Isolation and characterization of an ?-satellite repeated sequence from human chromosome 22

1986 • 64 citations

A cloned repeated DNA sequence in human chromosome heteromorphisms

1981 • 56 citations

Immunocytochemical localization of chromatin regions UV-microirradiated in S phase or anaphase

1983 • 41 citations