Continuum of overlapping clones spanning the entire human chromosome 21q

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors

1987 • 1,517 citations

A Common Language for Physical Mapping of the Human Genome

1989 • 876 citations

Toward a physical map of the genome of the nematode Caenorhabditis elegans

1986 • 631 citations

Radiation Hybrid Mapping: A Somatic Cell Genetic Method for Constructing High-Resolution Maps of Mammalian Chromosomes

1990 • 630 citations

Human genome organization: Alu, LINES, and the molecular structure of metaphase chromosome bands

1988 • 563 citations

Random-clone strategy for genomic restriction mapping in yeast.

1986 • 423 citations

Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents.

1990 • 408 citations

Yeast artificial chromosome libraries containing large inserts from mouse and human DNA.

1991 • 331 citations

Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions.

1990 • 187 citations

Construction of yeast artificial chromosome libraries with large inserts using fractionation by pulsed-field gel electrophoresis

1989 • 157 citations

Cloning human telomeric DNA fragments into Saccharomyces cerevisiae using a yeast-artificial-chromosome vector.

1989 • 150 citations

Physical mapping of human chromosomes by repetitive sequence fingerprinting.

1990 • 132 citations

PCR amplification of chromosome-specific alpha satellite DNA: Definition of centromeric STS markers and polymorphic analysis

1991 • 108 citations

Physical mapping of complex genomes by cosmid multiplex analysis.

1989 • 104 citations

Sequence-tagged site (STS) content mapping of human chromosomes: theoretical considerations and early experiences.

1991 • 103 citations

Ordering of cosmid clones covering the Herpes Simplex virus type I (HSV-I) genome: a test case for fingerprinting by hybridisation

1990 • 96 citations

Isolation of chromosome 21–specific yeast artificial chromosomes from a total human genome library

1992 • 88 citations

Partial physical map of human chromosome 21

1988 • 87 citations

A genetic linkage map of 27 markers on human chromosome 21

1991 • 79 citations

Yeast artificial chromosome-based genome mapping: Some lessons from Xq24–q28

1991 • 62 citations

In situ hybridization to cytogenetic bands of yeast artificial chromosomes covering 50% of human Xq24-Xq28 DNA.

1991 • 38 citations

Long-distance restriction mapping of the proximal long arm of human chromosome 21 with Not I linking clones.

1992 • 37 citations

A new multisequence family in human

1991 • 16 citations

Report of the committee on the genetic constitution of chromosome 21

1991 • 13 citations