Homocyst(e)ine and Coronary Artery Disease

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

1992 • 3,145 citations

Prevention of neural tube defects: Results of the Medical Research Council vitamin study

1992 • 2,294 citations

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

1991 • 2,191 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians

1992 • 1,686 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

The natural history of homocystinuria due to cystathionine beta-synthase deficiency.

1985 • 1,251 citations

Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

1995 • 1,244 citations

Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection

1987 • 1,072 citations

Disorders of transsulfuration

1989 • 1,053 citations

Total Plasma Homocysteine and Cardiovascular Risk Profile

1995 • 1,048 citations

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

1996 • 1,034 citations

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

1976 • 933 citations

Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men

1995 • 899 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.

1993 • 865 citations

Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine.

1986 • 826 citations

Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis.

1994 • 812 citations

Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease

1985 • 739 citations

Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies

1994 • 717 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Serum Total Homocysteine and Coronary Heart Disease

1995 • 668 citations

Homocystinemia

1974 • 655 citations

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.

1991 • 615 citations

Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase.

1988 • 607 citations

Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study

1994 • 540 citations

The pathogenesis of coronary artery disease. A possible role for methionine metabolism.

1976 • 535 citations

Homocystinuria: An Enzymatic Defect

1964 • 515 citations

Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia.

1996 • 503 citations

Metabolic Abnormalities Detected in a Survey of Mentally Backward Individuals in Northern Ireland

1962 • 494 citations

Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury

1980 • 489 citations

Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.

1988 • 479 citations

Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study.

1993 • 460 citations

Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects

1994 • 437 citations

Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.

1995 • 421 citations

Hyperhomocysteinemia and Low Pyridoxal Phosphate

1995 • 401 citations

Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator.

1986 • 390 citations

Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease

1994 • 386 citations

Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer

1995 • 380 citations

Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

1995 • 374 citations

Vitamin Requirements for the Treatment of Hyperhomocysteinemia in Humans

1994 • 373 citations

Diagnosis of cobalamin deficiency I: Usefulness of serum methylmalonic acid and total homocysteine concentrations

1990 • 355 citations

Homocysteine theory of arteriosclerosis

1975 • 338 citations

Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells.

1993 • 314 citations

Radioenzymic determination of homocysteine in plasma and urine.

1985 • 310 citations

Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease.

1986 • 307 citations

Plasma homocyst(e)ine levels in men with premature coronary artery disease

1990 • 304 citations

Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry

1987 • 291 citations

A Syndrome of Methylmalonic Aciduria, Homocystinuria, Megaloblastic Anemia and Neurologic Abnormalities in a Vitamin B₁₂-Deficient Breast-Fed Infant of a Strict Vegetarian

1978 • 272 citations

Hyperhomocyst(e)inemia. A common and easily reversible risk factor for occlusive atherosclerosis.

1990 • 266 citations

Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency

1993 • 265 citations

Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.

1995 • 263 citations

Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors

1992 • 261 citations

High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.

1994 • 251 citations

The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease

1991 • 250 citations

Local and systemic effects of cigarette smoking on folate and vitamin B−12

1994 • 250 citations

Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation

1996 • 246 citations

Homocysteine and Risk of Premature Coronary Heart Disease

1996 • 242 citations

Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons.

1983 • 241 citations

Prevalence of Moderate Hyperhomocysteinemia in Patients with Early-Onset Venous and Arterial Occlusive Disease

1995 • 235 citations

Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.

1993 • 230 citations

Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease

1995 • 227 citations

Redox Status and Protein Binding of Plasma Homocysteine and Other Aminothiols in Patients With Early-Onset Peripheral Vascular Disease

1995 • 215 citations

Plasma homocysteine in acute myocardial infarction: homocysteine‐lowering effect of folic acid

1995 • 212 citations

Plasma homocysteine and menopausal status**

1995 • 211 citations

Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects

1989 • 197 citations

Homocysteine and myocardial infarction

1988 • 197 citations

Plasma homocysteine in renal failure.

1993 • 195 citations

Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease

1994 • 180 citations

Hyperhomocysteinemia and traditional cardiovascular disease risk factors in end-stage renal disease patients on dialysis: a case-control study

1995 • 174 citations

Sulphur containing amino acids in chronic renal failure with particular reference to homocystine and cysteine‐homocysteine mixed disulphide

1979 • 171 citations

Hormone replacement therapy may reduce high serum homocysteine in postmenopausal women

1994 • 165 citations

Homocysteine metabolism and the oxidative modification of proteins and lipids

1993 • 164 citations

Decreased serum homocysteine in pregnancy.

1992 • 164 citations

Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism.

1993 • 157 citations

The effect of high-dose pyridoxine and folic acid supplementation on serum lipid and plasma homocysteine concentrations in dialysis patients.

1993 • 154 citations

Hyperhomocysteinemia following a methionine load in patients with non-insulin-dependent diabetes mellitus and macrovascular disease

1996 • 152 citations

Effects of age, lipoproteins, and hemostatic parameters on the role of homocyst(e)inemia as a cardiovascular risk factor in men.

1994 • 150 citations

Prevalence of familial hyperhomocyst(e)inemia in men with premature coronary artery disease.

1991 • 147 citations

Chemical pathology of homocysteine. I. Atherogenesis.

1993 • 145 citations

Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment

1993 • 145 citations

Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.

1993 • 143 citations

Homocysteine Increases as Folate Decreases in Plasma of Healthy Men during Short-Term Dietary Folate and Methyl Group Restriction

1994 • 139 citations

Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate.

1991 • 136 citations

Homocyst(e)inemia in daily practice

1990 • 135 citations

Role of blood pressure, uric acid, and hemorheological parameters on plasma homocyst(e)ine concentration

1995 • 133 citations

Measurement of homocyst(e)ine in the prediction of arteriosclerosis

1995 • 130 citations

Hyperhomocyst(e)inaemia: an independent risk factor for intermittent claudication

1992 • 128 citations

Plasma Homocysteine and Severity of Atherosclerosis in Young Patients With Lower-Limb Atherosclerotic Disease

1996 • 127 citations

The gene for cystathionine beta-synthase (CBS) maps to the subtelomeric region on human chromosome 21q and to proximal mouse chromosome 17.

1988 • 126 citations

Results of B-vitamin supplementation study used in a prediction model to define a reference range for plasma homocysteine

1995 • 115 citations

Increased lipid peroxidation as a mechanism of methionine-induced atherosclerosis in rabbits

1995 • 113 citations

Effect of Homocysteine and Homocystine on Platelet and Vascular Arachidonic Acid Metabolism

1982 • 111 citations

Plasma levels of the atherogenic amino acid homocysteine in postmenopausal women with breast cancer treated with tamoxifen

1995 • 109 citations

Molecular basis of phenotype expression in homocystinuria

1994 • 107 citations

Determination of plasma homocysteine by high-performance liquid chromatography with fluorescence detection

1989 • 100 citations

Improved identification of heterozygotes for homocystinuria due to cystathionine synthase deficiency by the combination of methionine loading and enzyme determination in cultured fibroblasts

1985 • 92 citations

Effective homocysteine metabolism may protect South African blacks against coronary heart disease

1995 • 91 citations

Higher Plasma Homocyst(e)ine and Increased Susceptibility to Adverse Effects of Low Folate in Early Familial Coronary Artery Disease

1995 • 89 citations

Vitamin B-6 nutrition status and cigarette smoking

1990 • 79 citations

Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis

1989 • 78 citations

Reduced, Free and Total Fractions of Homocysteine and Other Thiol Compounds in Plasma from Patients with Renal Failure

1995 • 76 citations

Hyperhomocysteinemia in patients operated for lower extremity ischaemia below the age of 50—effect of smoking and extent of disease

1993 • 76 citations

Plasma Homocysteine Levels in Patients With Deep Venous Thrombosis

1995 • 70 citations

Assignment of the gene for cystathionine ?-synthase to human chromosome 21 in somatic cell hybrids

1984 • 67 citations

Homocysteine thiolactone disposal by human arterial endothelial cells and serum in vitro.

1991 • 66 citations

Population variation and genetics of plasma homocyst(e)ine level

1992 • 63 citations

Vitamin Nutrition Status and Homocysteine: An Atherogenic Risk Factor

2009 • 62 citations

The Total Serum Homocysteine as an Indicator of Vitamin B12 and Folate Status

1988 • 58 citations

Clinical significance of pharmacological modulation of homocysteine metabolism

1990 • 57 citations

Hyperhomocysteinemia in premature arterial disease: examination of cystathionine β-synthase alleles at the molecular level

1995 • 57 citations

Age dependency of cystathionine beta-synthase activity in human fibroblasts in homocyst(e)inemia and atherosclerotic vascular disease

1992 • 56 citations

Hyperhomocyst(e)inemia in Utah siblings with early coronary disease

1990 • 51 citations

Effects of Ingestion of High Protein or Excess Methionine Diets by Rats for Two Years

1988 • 44 citations

Homocyst(e)ine and coronary artery disease

1992 • 43 citations

Homocysteine thiolactone, N-homocysteine thiolactonyl retinamide, and platelet aggregation.

1987 • 43 citations

Determination of homocysteine by HPLC with pulsed integrated amperometry

1995 • 41 citations

Colestipol plus niacin therapy elevates plasma homocyst(e)ine levels

1991 • 39 citations

Peroxide mediated effects of homocysteine on arterial prostacyclin synthesis

1986 • 38 citations

Homocysteine-Induced Oxidative Damage: Mechanisms and Possible Roles in Neurodegenerative and Atherogenic Processes

1995 • 37 citations

Two novel missense mutations in the cystathionine β-synthase gene in homocystinuric patients

1995 • 33 citations

Rapid determination of total homocysteine in plasma.

1989 • 32 citations

ANTITHROMBIN ACTIVITY IN HOMOCYSTINURIA

1975 • 29 citations

Thiolation of low-density lipoproteins and their interaction with L2C leukemic lymphocytes

1986 • 26 citations

The Role of Free Radicals as Mediators of Endothelial Cell Injury in Hyperhomocysteinemia

1992 • 24 citations

Supplemental folic acid

1993 • 17 citations

Influence of hydrolysis on plasma homocysteine determination in healthy subjects and patients with myocardial infarction

1991 • 13 citations

Lipoproteins and homocyst(e)ine as risk factors for atherosclerosis: assessment and treatment.

1995 • 11 citations

Changes in urinary homocysteine following synthetic Steroidal estrogen and progestogen administration to rats

1984 • 7 citations