Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent

1968 • 7,671 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

1991 • 2,191 citations

The aggregation of blood platelets

1963 • 2,125 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

1992 • 1,454 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.

1989 • 977 citations

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

1976 • 933 citations

Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase

1987 • 896 citations

Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine.

1986 • 826 citations

A scheme for the colorimetric determination of microgram amounts of thiols

1958 • 754 citations

Homocystinemia

1974 • 655 citations

H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.

1975 • 653 citations

Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury

1980 • 489 citations

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.

1987 • 465 citations

Selection and characterization of bovine aortic endothelial cells

1978 • 417 citations

Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells

1990 • 392 citations

Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator.

1986 • 390 citations

Homocysteine theory of arteriosclerosis

1975 • 338 citations

Radioenzymic determination of homocysteine in plasma and urine.

1985 • 310 citations

Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease.

1986 • 307 citations

Hyperhomocyst(e)inemia. A common and easily reversible risk factor for occlusive atherosclerosis.

1990 • 266 citations

Amino Acid Metabolism and Genetic Variation.

1968 • 263 citations

Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol

1990 • 260 citations

N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.

1989 • 245 citations

Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols.

1990 • 237 citations

Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor

1987 • 236 citations

Prostacyclin inhibits mobilisation of fibrinogen-binding sites on human ADP- and thrombin-treated platelets

1980 • 193 citations

Possible involvement of S‐nitrosothiols in the activation of guanylate cyclase by nitroso compounds

1980 • 173 citations

Cardiovascular effects of acute hypercholesterolemia in rabbits. Reversal with lovastatin treatment.

1989 • 159 citations

Capillary zone electrophoretic detection of biological thiols and their S-nitrosated derivatives

1992 • 151 citations

Endothelial cell dysfunction in homocystinuria

1983 • 142 citations

HOMOCYSTINURIA, THROMBOSIS, AND THE BLOOD-PLATELETS

1964 • 138 citations

Production of arteriosclerosis by homocysteinemia.

1970 • 138 citations

H2O2 and endothelium-dependent cerebral arteriolar dilation. Implications for the identity of endothelium-derived relaxing factor generated by acetylcholine.

1990 • 113 citations

Effect of Homocysteine and Homocystine on Platelet and Vascular Arachidonic Acid Metabolism

1982 • 111 citations

ORGANIC THIONITRITES AND RELATED SUBSTANCES. A REVIEW

1983 • 96 citations

Cytotoxicity of cysteine in culture media

1976 • 92 citations

THE ISOLATION OF HOMOCYSTEINE AND ITS CONVERSION TO A THIOLACTONE

1935 • 76 citations

Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism.

1985 • 74 citations

Platelet Aggregation Caused by Dithiothreitol

1984 • 73 citations

Homocysteine Metabolism in Scurvy, Growth and Arteriosclerosis

1971 • 69 citations

Sulfur-containing amino acids in the plasma and urine of homocystinurics

1967 • 68 citations

Platelet Survival and Morphology in Homocystinuria Due to Cystathionine Synthase Deficiency

1976 • 60 citations

Reduced thiols and the effect of intravenous nitroglycerin on platelet aggregation

1988 • 54 citations

Kinetics and Distribution of¹¹¹Indium-Labeled Platelets in Patients with Homocystinuria

1982 • 50 citations

The spectrum of diseases of small coronery arteries and their physiologic consequences

1990 • 49 citations

Homocysteine thiolactone, N-homocysteine thiolactonyl retinamide, and platelet aggregation.

1987 • 43 citations

Reaction of acidified nitrite solutions with peptide derivatives: evidence for nitrosamine and thionitrite formation from 15N N.m.r. Studies

1975 • 42 citations

Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells

1990 • 38 citations

Dissociation of platelet activation from transmethylation of their membrane phospholipids

1981 • 35 citations

The influence of glutathione and other thiols on human platelet aggregation

1986 • 30 citations

Conversion of methionine to homocysteine thiolactone in liver

1974 • 28 citations

INVESTIGATIONS OF COAGULATION AND FIBRINOLYSIS IN HOMOCYSTINURIA

1974 • 27 citations

Direct staining and visualization of endothelial monolayers cultured on synthetic polycarbonate filters.

1988 • 21 citations

Inhibition of human platelet aggregation by endothelium-derived relaxing factor, sodium nitroprusside or iloprost is potentiated by captopril and reduced thiols.

1991 • 17 citations

An Intrinsic Blood Platelet Abnormality in an Homocystinuric Boy, Corrected by Pyridoxine Administration

1971 • 10 citations

Amino Acids and Collagen-Induced Platelet Aggregation

1975 • 9 citations

Effect of compounds causing reversible perturbation of the cellular thiol-disulfide status on the aggregation of human blood platelets.

1983 • 7 citations

3 Deazaadenosine and L-homocysteine inhibit human platelet activation induced by arachidonic acid, U46619 and phospholipase C

1984 • 5 citations

[Significance of sulfhydryl, amino and carboxyl groups in nectrotropic liver protective action of short-chain hydrocarbons].

1957 • 5 citations