Helix-Loop-Helix Motif in HIV-1 Rev

Prediction of protein conformation

1974 • 3,327 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Estimation of globular protein secondary structure from circular dichroism

1981 • 2,139 citations

On Finding All Suboptimal Foldings of an RNA Molecule

1989 • 2,019 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)

1985 • 872 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

1989 • 742 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

Helix Signals in Proteins

1988 • 648 citations

A second post-transcriptional trans-activator gene required for HTLV-III replication

1986 • 639 citations

Effect of trifluoroethanol on protein secondary structure: an NMR and CD study using a synthetic actin peptide

1992 • 582 citations

Defining Solution Conformations of Small Linear Peptides

1991 • 528 citations

Tat Protein from Human Immunodeficiency Virus Forms a Metal-Linked Dimer

1988 • 464 citations

HIV-1 structural gene expression requires binding of the rev trans-activator to its RNA target sequence

1990 • 457 citations

HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latency

1991 • 422 citations

Sequence-specific recognition of RNA hairpins by bacteriophage antiterminators requires a conserved arginine-rich motif

1989 • 395 citations

Sequence-specific RNA binding by the HIV-1 Rev protein

1989 • 384 citations

Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro

1989 • 377 citations

The automated chemical synthesis of long oligoribuncleotides using 2'-O-silylated ribonucleoside 3'-O-phosphoramidites on a controlled-pore glass support: synthesis of a 43-nucleotide sequence similar to the 3'-half molecule of an Escherichia coli formylmethionine tRNA

1987 • 367 citations

Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy

1990 • 340 citations

Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognition.

1991 • 328 citations

Mutational definition of the human immunodeficiency virus type 1 Rev activation domain

1991 • 276 citations

RNA recognition by an isolated α helix

1993 • 265 citations

Chemical synthesis of biologically active oligoribonucleotides using β-cyanoethyl protected ribonucleoside phosphoramidites

1990 • 262 citations

Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif.

1991 • 253 citations

Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila.

1991 • 238 citations

Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif.

1990 • 236 citations

Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.

1991 • 200 citations

Secondary Structure is the Major Determinant for Interaction of HIV rev Protein with RNA

1990 • 188 citations

Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.

1992 • 181 citations

Peptide models of protein folding initiation sites. 1. Secondary structure formation by peptides corresponding to the G- and H-helixes of myoglobin

1993 • 175 citations

Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.

1990 • 166 citations

Molecular Characterization of Helix-Loop-Helix Peptides

1992 • 166 citations

Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminus

1990 • 158 citations

Relationship between amide proton chemical shifts and hydrogen bonding in amphipathic .alpha.-helical peptides

1992 • 157 citations

Functional Analysis of CAR, the Target Sequence for the Rev Protein of HIV-1

1989 • 152 citations

Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif

1991 • 147 citations

Total chemical synthesis of a 77-nucleotide-long RNA sequence having methionine-acceptance activity.

1988 • 144 citations

Characterization of HIV-1 REV protein: binding stoichiometry and minimal RNA substrate

1991 • 143 citations

Identification oftrans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells

1990 • 128 citations

RNA binding assays for Tat-derived peptides: implications for specificity

1992 • 116 citations

Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator.

1992 • 114 citations

The art gene product of human immunodeficiency virus is required for replication

1988 • 107 citations

Prevention of chain cleavage in the chemical synthesis of 2′-silylated oligoribonucleotides

1989 • 94 citations

A highly conserved RNA folding region coincident with the Rev response element of primate immunodeficiency viruses

1990 • 88 citations

HIV-1 Rev expressed in recombinant Escherichia coli: purification, polymerization, and conformational properties

1991 • 86 citations

Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype

1990 • 78 citations

Biochemical characterization of binding of multiple HIV-1 Rev monomeric proteins to the Rev responsive element

1993 • 76 citations

Circular dichroism and molecular modeling yield a structure for the complex of human immunodeficiency virus type 1 trans-activation response RNA and the binding region of Tat, the trans-acting transcriptional activator.

1992 • 76 citations

Mode of expression of the positive regulatory genes PHO2 and PHO4 of the phosphatase regulon in Saccharomyces cerevisiae

1989 • 75 citations

Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange

1992 • 75 citations

Peptide models of protein folding initiation sites. 2. The G-H turn region of myoglobin acts as a helix stop signal

1993 • 73 citations

Circular dichroism studies suggest that TAR RNA changes conformation upon specific binding of arginine or guanidine

1992 • 69 citations

Position-dependent stabilizing effects in .alpha.-helices: N-terminal capping in synthetic model peptides

1992 • 69 citations

Activating region of HIV-1 Tat protein: vacuum UV circular dichroism and energy minimization

1991 • 60 citations

Circular dichroism studies of the HIV-1 Rev protein and its specific RNA binding site

1990 • 58 citations

Predicted Structural Similarities of the DNA Binding Domains of c-Myc and Endonuclease Eco RI

1992 • 49 citations

Characterization of recombinant HIV-1 Tat and its interaction with TAR RNA

1992 • 42 citations

Purification and characterization of recombinant Rev protein of human immunodeficiency virus type 1.

1990 • 36 citations

Perturbation of the carboxy terminus of HIV-1 Rev affects multimerization on the Rev responsive element

1993 • 35 citations

Proposed structure for the DNA-binding domain of the Helix—Loop—Helix family of eukaryotic gene regulatory proteins

1993 • 19 citations