Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognition.

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

[5] Synthesis of small RNAs using T7 RNA polymerase

1989 • 1,072 citations

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

1987 • 902 citations

Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA ^Gln and ATP at 2.8 Å Resolution

1989 • 888 citations

Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)

1985 • 872 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1985 • 825 citations

Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

1986 • 730 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein

1987 • 672 citations

Tat trans-activates the human immunodeficiency virus through a nascent RNA target

1989 • 644 citations

The trans-activator gene of HTLV-III is essential for virus replication

1986 • 635 citations

The trans-activator gene of the human T cell lymphotropic virus type III is required for replication

1986 • 615 citations

HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation

1989 • 577 citations

Location of the Trans -Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type III

1985 • 558 citations

HIV-1 tat trans-activation requires the loop sequence within tar

1988 • 551 citations

Trans -Acting Transcriptional Regulation of Human T-Cell Leukemia Virus Type III Long Terminal Repeat

1985 • 500 citations

Structure of the Lambda Complex at 2.5 Å Resolution: Details of the Repressor-Operator Interactions

1988 • 500 citations

Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.

1989 • 472 citations

Tat Protein from Human Immunodeficiency Virus Forms a Metal-Linked Dimer

1988 • 464 citations

Fragments of the HIV-1 Tat Protein Specifically Biand TAR RNA

1990 • 446 citations

Structural and functional characterization of human immunodeficiency virus tat protein

1989 • 444 citations

Acid blobs and negative noodles

1988 • 438 citations

Solution structure of an unusually stable RNA hairpin, 5GGAC(UUCG)GUCC

1990 • 420 citations

A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation.

1990 • 412 citations

Sequence-specific recognition of RNA hairpins by bacteriophage antiterminators requires a conserved arginine-rich motif

1989 • 395 citations

Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins

1989 • 358 citations

Proteins : structures and molecular principles

1983 • 357 citations

Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat.

1989 • 357 citations

Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III

1986 • 325 citations

Sequence-Specific DNA Binding by a Short Peptide Dimer

1990 • 318 citations

Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

1986 • 303 citations

Design of DNA-Binding Peptides Based on the Leucine Zipper Motif

1990 • 296 citations

RNA-Protein Interactions in 30 S Ribosomal Subunits: Folding and Function of 16 S rRNA

1989 • 292 citations

HIV-1 Tat protein trans-activates transcription in vitro

1990 • 277 citations

Expression and Characterization of the Trans -Activator of HTLV-III/LAV Virus

1986 • 276 citations

Human immunodeficiency virus type 1 LTR TATA and TAR region sequences required for transcriptional regulation.

1989 • 275 citations

Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein

1989 • 270 citations

A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activator.

1988 • 270 citations

TAR-independent activation of the HIV-1 LTR: Evidence that Tat requires specific regions of the promoter

1990 • 253 citations

Multiple functional domains of Tat, thetrans-activator of HIV-1, defined by mutational analysis

1989 • 251 citations

Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events.

1987 • 246 citations

Trans-activation by HIV-1 Tat via a heterologous RNA binding protein

1990 • 236 citations

Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat

1988 • 235 citations

trans activation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-acting-responsive hairpin: a quantitative analysis

1989 • 224 citations

Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus.

1990 • 217 citations

RNA binding site of R17 coat protein

1987 • 210 citations

Functional domains required for tat-induced transcriptional activation of the HIV-1 long terminal repeat.

1988 • 193 citations

Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein

1990 • 192 citations

A Quantitative Bioassay for HIV-1 Based on Trans-Activation

1988 • 180 citations

RNA bulges and the helical periodicity of double-stranded RNA

1990 • 163 citations

Transcriptional but not translational regulation of HIV-1 by the tat gene product

1988 • 158 citations

Effects of a highly basic region of human immunodeficiency virus Tat protein on nucleolar localization

1990 • 158 citations

Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product

1990 • 155 citations

Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence

1990 • 142 citations

HIV-1 TAT “activates” presynthesized RNA in the nucleus

1989 • 135 citations

Identification of cellular proteins that bind to the human immunodeficiency virus type 1 trans-activation-responsive TAR element RNA.

1989 • 129 citations

Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region.

1989 • 121 citations

Solution conformation of an RNA hairpin loop

1990 • 110 citations

Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein

1990 • 102 citations

Dimerization of the tat protein from human immunodeficiency virus: a cysteine-rich peptide mimics the normal metal-linked dimer interface.

1988 • 98 citations

Activity of synthetic peptides from the Tat protein of human immunodeficiency virus type 1.

1989 • 96 citations

A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat.

1990 • 95 citations

Missense mutations in an infectious human immunodeficiency viral genome: functional mapping of tat and identification of the rev splice acceptor.

1988 • 91 citations

Synthesis of the complete trans-activation gene product of human T-lymphotropic virus type III in Escherichia coli: demonstration of immunogenicity in vivo and expression in vitro.

1986 • 90 citations

Functional comparison of transactivation by simian immunodeficiency virus from rhesus macaques and human immunodeficiency virus type 1

1988 • 75 citations

Thermal unfolding studies of a leucine zipper domain and its specific DNA complex: implications for scissor's grip recognition

1990 • 73 citations

A region of basic amino-acid cluster in HIV-1 Tat protein is essential forTrans-acting activity and nucleolar localization

1989 • 67 citations

Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix.

1990 • 61 citations

Trifluoroacetic Acid

1978 • 60 citations

Circular dichroism studies of the HIV-1 Rev protein and its specific RNA binding site

1990 • 58 citations

The TFIIIA recognition fragment d(GGATGGGAG)·d(CTCCCATCC) is B-form in solution

1988 • 47 citations

Functional substitution of the basic domain of the HIV-1 trans-activator, Tat, with the basic domain of the functionally heterologous Rev

1990 • 47 citations

Role of the cysteine-rich region of HIV tat protein on its trans-activational ability

1989 • 13 citations

Deleted Work

1955 • 0 citations