Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

Serine Palmitoyltransferase Is the Primary Target of a Sphingosine-like Immunosuppressant, ISP-1/Myriocin

1995 • 537 citations

Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.

1994 • 532 citations

Biochemistry of Lipids, Lipoproteins and Membranes

1996 • 352 citations

Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids

1993 • 281 citations

The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis.

1994 • 228 citations

Human and Murine Serine‐Palmitoyl‐CoA Transferase

1997 • 199 citations

Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways.

1992 • 193 citations

Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids

1991 • 185 citations

Mammalian Cell Mutants Resistant to a Sphingomyelin-directed Cytolysin

1998 • 181 citations

Genetic Evidence for ATP-dependent Endoplasmic Reticulum-to-Golgi Apparatus Trafficking of Ceramide for Sphingomyelin Synthesis in Chinese Hamster Ovary Cells

1999 • 169 citations

N,N-Dimethylsphingosine Inhibition of Sphingosine Kinase and Sphingosine 1-Phosphate Activity in Human Platelets

1996 • 162 citations

A Mammalian Homolog of the Yeast LCB1 Encodes a Component of Serine Palmitoyltransferase, the Enzyme Catalyzing the First Step in Sphingolipid Synthesis

1997 • 142 citations

Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase.

1992 • 135 citations

Potent Immunosuppressants, 2-Alkyl-2-aminopropane-1,3-diols

1996 • 134 citations

Inhibition of Sphingolipid Synthesis by Cycloserine In Vitro and In Vivo

1984 • 110 citations

Catalytic Asymmetric Syntheses of Antifungal Sphingofungins and Their Biological Activity as Potent Inhibitors of Serine Palmitoyltransferase (SPT)

1998 • 84 citations

Sphingosine-1-Phosphate Lyase 1

2020 • 80 citations

Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by .beta.-chloroalanine

1988 • 78 citations

Viridiofungins, Novel Inhibitors of Sphingolipid Synthesis.

1997 • 77 citations

Dual Roles of Sphingolipids in Signaling of the Escape from and Onset of Apoptosis in a Mouse Cytotoxic T-cell Line, CTLL-2

1996 • 74 citations

Inhibition of serine palmitoyl-transferase activity by lipoxamycin.

1994 • 64 citations

Sphingolipid deficiency induces hypersensitivity of CD14, a glycosyl phosphatidylinositol-anchored protein, to phosphatidylinositol-specific phospholipase C

1993 • 42 citations

Selection of Mammalian Cell Mutants in Sphingolipid Biosynthesis

2000 • 18 citations

Sphingosine-1-Phosphate Lyase

2007 • 18 citations

ChemInform Abstract: Catalytic Asymmetric Syntheses of Antifungal Sphingofungins and Their Biological Activity as Potent Inhibitors of Serine Palmitoyltransferase (SPT).

1998 • 6 citations