Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 8,631 citations

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1995 • 7,378 citations

Beyond Cholesterol

1989 • 6,533 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease

1994 • 1,697 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

Increase in Circulating Products of Lipid Peroxidation (F₂-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage

1995 • 1,343 citations

The measurement and mechanism of lipid peroxidation in biological systems

1990 • 1,273 citations

Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease.

1993 • 833 citations

The Yin and Yang of Oxidation in the Development of the Fatty Streak

1996 • 705 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Modulation of Oxidant Stress In Vivo in Chronic Cigarette Smokers

1996 • 621 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

Myocardial 'stunning' in man.

1992 • 531 citations

Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues.

1989 • 518 citations

Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors.

1992 • 510 citations

Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease.

1983 • 464 citations

The Antioxidant Vitamins and Cardiovascular Disease: A Critical Review of Epidemiologic and Clinical Trial Data

1995 • 407 citations

Plasma 8‐epi‐PGF_2α levels are elevated in individuals with non‐insulin dependent diabetes mellitus

1995 • 394 citations

Localization of distinct F2-isoprostanes in human atherosclerotic lesions.

1997 • 345 citations

Immunological characterization of urinary 8-epi-prostaglandin F2 alpha excretion in man.

1995 • 340 citations

Acute myocardial dysfunction and recovery: A common occurrence after coronary bypass surgery

1990 • 322 citations

α-Tocopherol Inhibits Aggregation of Human Platelets by a Protein Kinase C–Dependent Mechanism

1996 • 309 citations

Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes.

1994 • 305 citations

8-Epi PGF _2α Generation During Coronary Reperfusion

1997 • 272 citations

Reduced Plasma Peroxyl Radical Trapping Capacity and Increased Susceptibility of LDL to Oxidation In Poorly Controlled IDDM

1994 • 272 citations

Cylooxygenase-dependent Formation of the Isoprostane, 8-Epi Prostaglandin F2α

1995 • 262 citations

Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells

1993 • 260 citations

Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro.

1994 • 248 citations

The F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist

1992 • 214 citations

Beneficial actions of superoxide dismutase and catalase in stunned myocardium of dogs

1986 • 205 citations

Local Amplification of Platelet Function by 8-Epi Prostaglandin F2α Is Not Mediated by Thromboxane Receptor Isoforms

1996 • 205 citations

Generation of 8-Epiprostaglandin F by Human Monocytes

1996 • 189 citations

Increased thromboxane biosynthesis in type IIa hypercholesterolemia.

1992 • 168 citations

The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha.

1997 • 163 citations

Antioxidant Vitamins and Cardiovascular Disease

1997 • 161 citations

Enhanced in vitro oxidation of plasma lipoproteins derived from hypercholesterolemic patients

1991 • 159 citations

Identification of the Major Urinary Metabolite of the F2-isoprostane 8-Iso-prostaglandin F2α in Humans

1996 • 159 citations

Identification of non-cyclooxygenase-derived prostanoid (F2-isoprostane) metabolites in human urine and plasma.

1993 • 158 citations

Assay of Malondialdehyde in Biological Fluids by Gas Chromatography-Mass Spectrometry

1994 • 149 citations

Stereochemical course of the autooxidative cyclization of lipid hydroperoxides to prostaglandin-like bicyclic endoperoxides

1984 • 120 citations

Functional Characterization of the Ocular Prostaglandin F2α (PGF2α) Receptor

1997 • 103 citations

Lipid peroxidation associated with successful thrombolysis

1990 • 101 citations

Isoleukotrienes Are Biologically Active Free Radical Products of Lipid Peroxidation

1995 • 100 citations

Lipoprotein Oxidation and Lipoprotein-lnduced Cell Injury in Diabetes

1992 • 91 citations

Evidence for episodic platelet activation in acute ischemic stroke.

1994 • 84 citations

Effects of the novel anti‐inflammatory compounds, N‐[2‐(cyclohexyloxy)‐4‐nitrophenyl] methanesulphonamide (NS‐398) and 5‐methanesulphonamido‐6‐(2, 4‐difluorothiophenyl)‐1‐indanone (L‐745, 337), on the cyclo‐oxygenase activity of human blood prostaglandin endoperoxide synthases

1995 • 83 citations

Assessment of myocardial oxidative stress in patients after myocardial revascularization

1988 • 82 citations

Induction of prostaglandin endoperoxide synthase‐2 in human monocytes associated with cyclo‐oxygenase‐dependent F₂‐isoprostane formation

1996 • 76 citations

Human globin gene analysis for a patient with beta-o/delta beta-thalassemia.

1975 • 68 citations

Cyclooxygenase‐Dependent Formation of the Isoprostane 8‐EPI Prostaglandin F_2α^a

1994 • 66 citations

Total synthesis of a novel isoprostane IPF2α-I and its identification in biological fluids

1996 • 56 citations

Is Pentane a Normal Constituent of Human Breath?

1993 • 50 citations

Thromboxane biosynthesis and metabolism in relation to cardiovascular risk factors

1992 • 37 citations

The susceptibility of low-density lipoprotein to in vitro oxidation is increased in hypercholesterolemic patients.

1994 • 28 citations

Free radical activity and left ventricular function after thrombolysis for acute infarction.

1993 • 21 citations