Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Beyond Cholesterol

1989 • 6,533 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

1992 • 1,332 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

1981 • 1,037 citations

Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.

1991 • 786 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids.

1992 • 742 citations

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

1990 • 621 citations

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

1984 • 547 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant

1992 • 513 citations

Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors.

1992 • 510 citations

Noncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoids

1990 • 480 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

[8] Single vertical spin density gradient ultracentrifugation

1986 • 449 citations

Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes

1985 • 428 citations

Suggested mechanism for the production of malonaldehyde during the autoxidation of polyunsaturated fatty acids. Nonenzymic production of prostaglandin endoperoxides during autoxidation

1975 • 389 citations

Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide.

1991 • 331 citations

Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C

1990 • 321 citations

Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation.

1992 • 319 citations

The pathogenesis of atherosclerosis: An overview

1991 • 306 citations

Ascorbate: The Most Effective Antioxidant in Human Blood Plasma

1990 • 286 citations

Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions.

1993 • 278 citations

Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation.

1993 • 275 citations

Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma

1988 • 255 citations

Interaction of vitamin C and vitamin E during free radical stress in plasma: An ESR study

1993 • 243 citations

Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells.

1991 • 228 citations

Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase.

1989 • 220 citations

The F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist

1992 • 214 citations

Effect of vitamin C and E supplementation on susceptibility of plasma lipoproteins to peroxidation induced by acute smoking

1990 • 205 citations

Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor.

1991 • 190 citations

Phospholipase A2 activity of low density lipoprotein: evidence for an intrinsic phospholipase A2 activity of apoprotein B-100.

1990 • 139 citations

Peroxy radical cyclization as a model for prostaglandin biosynthesis

1975 • 134 citations

Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ

1992 • 127 citations

Oxidized low‐density lipoprotein increases cultured human endothelial cell tissue factor activity and reduces protein C activation ¹

1991 • 113 citations

[38] Assay of lipid hydroperoxides using high-performance liquid chromatography with isoluminal chemiluminescence detection

1990 • 100 citations

Quantification of noncyclooxygenase derived prostanoids as a marker of oxidative stress

1991 • 97 citations

Oxidatively modified human low-density lipoprotein stimulates leukocyte adherence to the microvascular endothelium in vivo

1991 • 55 citations

Hypertrophic cardiomyopathy: Prognosis with medical or surgical therapy

1991 • 30 citations