Functional Characterization of the Ocular Prostaglandin F2α (PGF2α) Receptor

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Oxidative stress‐induced cataract: mechanism of action

1995 • 891 citations

Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids.

1992 • 742 citations

Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity

1993 • 546 citations

Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors.

1992 • 510 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

The isoprostanes

1996 • 451 citations

Prostaglandin and thromboxane biosynthesis

1991 • 444 citations

Cloning and expression of a cDNA for the human prostanoid FP receptor.

1994 • 386 citations

Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.

1994 • 357 citations

Uterine luteolytic hormone: a physiological role for prostaglandin F2alpha

1976 • 354 citations

Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes.

1994 • 305 citations

Prostaglandin F2α increases uveoscleral outflow in the cynomolgus monkey

1989 • 266 citations

Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells

1993 • 260 citations

The Effects on Aqueous Dynamics of PhXA41, a New Prostaglandin F2α Analogue, After Topical Application in Normal and Ocular Hypertensive Human Eyes

1993 • 249 citations

Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C

1996 • 246 citations

Cloning and expression of a cDNA for mouse prostaglandin F receptor.

1994 • 232 citations

Corpus Luteum Regression Induced by Prostaglandin F_2α¹

1970 • 228 citations

Pilocarpine Antagonizes Prostaglandin F2α-Induced Ocular Hypotension in Monkeys

1987 • 226 citations

In vitro characterization of prostanoid receptors on human myometrium at term pregnancy

1993 • 214 citations

Local Amplification of Platelet Function by 8-Epi Prostaglandin F2α Is Not Mediated by Thromboxane Receptor Isoforms

1996 • 205 citations

Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha.

1975 • 196 citations

Generation of 8-Epiprostaglandin F by Human Monocytes

1996 • 189 citations

Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues

1986 • 167 citations

Allodynia evoked by intrathecal administration of prostaglandin F2α to conscious mice

1992 • 165 citations

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.

1993 • 159 citations

Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.

1988 • 143 citations

Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor.

1994 • 136 citations

Stereochemical course of the autooxidative cyclization of lipid hydroperoxides to prostaglandin-like bicyclic endoperoxides

1984 • 120 citations

In vitro characterization of prostanoid FP‐, DP‐, IP‐ and TP‐receptors on the non‐pregnant human myometrium

1992 • 113 citations

Cloning of a Carboxyl-terminal Isoform of the Prostanoid FP Receptor

1997 • 110 citations

Prostaglandin F2α Stimulates Hypertrophic Growth of Cultured Neonatal Rat Ventricular Myocytes

1996 • 107 citations

Rapid, Agonist-dependent Phosphorylation in Vivo of Human Thromboxane Receptor Isoforms

1997 • 89 citations

Vascular Smooth Muscle Actions and Receptor Interactions of 8-Iso-prostaglandin E2, an E2-Isoprostane

1993 • 84 citations

Free radicals in retinal and choroidal blood flow autoregulation in the piglet: interaction with prostaglandins.

1994 • 73 citations

Cloning of the rat and human prostaglandin F_2α receptors and the expression of the rat prostaglandin F_2α receptor

1994 • 70 citations

Cloning of a receptor for prostaglandin F2 alpha from the ovine corpus luteum.

1995 • 65 citations

Mass spectrometric analysis of four regioisomers of F₂-isoprostanes formed by free radical oxidation of arachidonic acid

1996 • 63 citations

Agonist-dependent Phosphorylation of an Epitope-tagged Human Prostacyclin Receptor

1996 • 61 citations

Total Synthesis of 8-epi-PGF2.alpha.. A Novel Strategy for the Synthesis of Isoprostanes

1994 • 58 citations

Total synthesis of a novel isoprostane IPF2α-I and its identification in biological fluids

1996 • 56 citations

Induction of c-fos by prostaglandin F2 alpha in human ciliary smooth muscle cells.

1994 • 52 citations

Prostaglandin F2 alpha effects on intraocular pressure negatively correlate with FP-receptor stimulation.

1989 • 47 citations

Peroxymercuration-demercuration of lipid hydroperoxides

1984 • 36 citations

Characterization of prostaglandin F_2α receptor of mouse 3T3 fibroblasts and its functional expression in Xenopus laevis oocytes

1993 • 34 citations

Total synthesis of 12-epi-PGF2α

1996 • 31 citations

First total synthesis of isoprostane IPF2α-III

1997 • 23 citations

Protein kinase C is involved in cyclic adenosine monophosphate formation due to PGF2 alpha desensitization in bovine iris sphincter.

1993 • 12 citations

The effect of the prostaglandin F2α analogue ICI 81008 on uterine small arteries and on blood pressure

1975 • 11 citations

Evaluation of prostaglandin F2 alpha and prostacyclin interactions in the isolated perfused rat lung

1992 • 9 citations

Desensitization of prostaglandin F2? receptor-mediated phosphoinositide hydrolysis in cultured rat astrocytes

1994 • 8 citations