Isoleukotrienes Are Biologically Active Free Radical Products of Lipid Peroxidation

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Free radicals in biology and medicine

1991 • 17,840 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Hepatogastroenterology

2012 • 2,160 citations

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

Reactive oxygen species in living systems: Source, biochemistry, and role in human disease

1991 • 1,827 citations

Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences

1990 • 1,143 citations

Oxy-Radicals and Related Species: Their Formation, Lifetimes, and Reactions

1986 • 958 citations

Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress

1992 • 539 citations

Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence

1981 • 396 citations

The potential of the hydrocarbon breath test as a measure of lipid peroxidation

1994 • 362 citations

Reactive oxygen and ischemia/reperfusion injury of the liver

1991 • 325 citations

Identification of molecular species of glycerophospholipids and sphingomyelin using electrospray mass spectrometry.

1994 • 322 citations

Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes.

1994 • 305 citations

Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.

1984 • 304 citations

Unequivocal demonstration that malondialdehyde is a mutagen

1983 • 269 citations

The F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist

1992 • 214 citations

Direct demonstration of increased intracellular concentration of free calcium in rabbit and human neutrophils following stimulation by chemotactic factor

1983 • 199 citations

Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor

1993 • 142 citations

Airway and vascular effects of 8-epi-prostaglandin F2 alpha in isolated perfused rat lung

1993 • 140 citations

Functional characterization of synthetic leukotriene B and its stereochemical isomers.

1981 • 130 citations

Role of prostaglandin endoperoxides in the serum thiobarbituric acid reaction

1981 • 116 citations

Simultaneous measurement of stimulus-induced changes in cytoplasmic Ca2+ and in membrane potential of human neutrophils.

1986 • 93 citations

LTB4 induced activation signals and responses in neutrophils are short-lived compared to formylpeptide.

1987 • 67 citations

Transduction by leukotriene B4 receptors of increases in cytosolic calcium in human polymorphonuclear leukocytes.

1985 • 67 citations

Role of lipid structure in the activation of phospholipase A₂ by peroxidized phospholipids

1993 • 65 citations

Stereospecificity of leukotriene B4 and structure-function relationships for chemotaxis of human neutrophils.

1984 • 58 citations

Collision-induced dissociation of F2-isoprostane-containing phospholipids

1993 • 56 citations

Analysis of hydroxy fatty acids as pentafluorobenzyl ester, trimethylsilyl ether derivatives by electron ionization gas chromatography/mass spectrometry

1995 • 33 citations

Comparative effect of leukotriene B4 and leukotriene B5 on calcium mobilization in human neutrophils

1988 • 30 citations

Binding of leukotriene B4 and its analogs to human polymorphonuclear leukocyte membrane receptors

1987 • 29 citations

Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982.

1992 • 23 citations

Analogs of leukotriene B4: Effects of modification of the hydroxyl groups on leukocyte aggregation and binding to leukocyte leukotriene B4 receptors

1987 • 21 citations

Important contribution of the methylene part of LTB4 toward binding affinity to the LTB4 receptors and rise in intracellular-free calcium concentration

1994 • 8 citations

Structure/activity relationship of leukotriene B₄ and its structural analogues in chemotactic, lysosomal‐enzyme release and receptor‐binding assays

1993 • 6 citations