Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: The central role of proinflammatory cytokines

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

2001 • 8,356 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR

1999 • 736 citations

Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.

1993 • 520 citations

Regulation of Cytochromes P450 During Inflammation and Infection

1997 • 477 citations

Induction of Drug Metabolism: The Role of Nuclear Receptors

2003 • 449 citations

Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor

1996 • 449 citations

CURCUMIN INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION BY HUMAN PERIPHERAL BLOOD MONOCYTES AND ALVEOLAR MACROPHAGES

1999 • 443 citations

Regulation of cytochrome p450 by inflammatory mediators: why and how?

2001 • 358 citations

Inhibition of tumor necrosis factor by curcumin, a phytochemical

1995 • 302 citations

Regulation of cytochrome P450 (CYP) genes by nuclear receptors

2000 • 260 citations

Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.

1994 • 220 citations

Pharmacokinetic and Pharmacodynamic Considerations When Treating Patients with Sepsis and Septic Shock

2002 • 171 citations

Definition of a Minimal Domain of the Dioxin Receptor That Is Associated with Hsp90 and Maintains Wild Type Ligand Binding Affinity and Specificity

1995 • 164 citations

Suppression of constitutive cytochrome P-450 gene expression in livers of rats undergoing an acute phase response to endotoxin.

1989 • 164 citations

Mechanism of hepatocellular dysfunction during hyperdynamic sepsis

1996 • 160 citations

Curcumin ameliorates ethanol and nonethanol experimental pancreatitis

2003 • 156 citations

Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure

2003 • 144 citations

Interleukin-1 beta suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes.

1992 • 139 citations

Heat shock protein hsp90 regulates dioxin receptor function in vivo.

1995 • 120 citations

Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function

2004 • 115 citations

Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells

1992 • 96 citations

Cytochrome P450 3A4 activity after surgical stress

2003 • 92 citations

Effect of Curcuminoids as Anti-Inflammatory Agents on the Hepatic Microvascular Response to Endotoxin

2002 • 89 citations

Differential Regulation of Cytokines and Transcription Factors in Liver by Curcumin Following Hemorrhage/Resuscitation

2003 • 83 citations

The ARYL Hydrocarbon Receptor Complex

1995 • 81 citations

Curcumin, a medicinal herbal compound capable of inducing the heat shock response

2001 • 78 citations

Dexamethasone Modulation of In Vivo Effects of Endotoxin, Tumor Necrosis Factor, and Interleukin-1 on Liver Cytochrome P-450, Plasma Fibrinogen, and Serum Iron

1989 • 72 citations

MODULATION OF DRUG METABOLISM IN INFECTIOUS AND INFLAMMATORY DISEASES*

1999 • 66 citations

Rapid Transcriptional Suppression of Rat Cytochrome P450 Genes by Endotoxin Treatment and Its Inhibition by Curcumin

2003 • 60 citations

Structure-Activity Relationship of Nuclear Receptor-Ligand Interactions

2003 • 56 citations

Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome p450

1996 • 55 citations

Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis

2004 • 48 citations

Effect of interleukin 1 (IL-1) on the levels of cytochrome P-450 involving IL-1 receptor on the isolated hepatocytes of rat

1990 • 45 citations

Lipopolysaccharide and Cecal Ligation/Puncture Differentially Affect the Subcellular Distribution of the Pregnane X Receptor but Consistently Cause Suppression of Its Target Genes CYP3A

2003 • 42 citations

Ligand-Dependent Recruitment of the Arnt Coregulator Determines DNA Recognition by the Dioxin Receptor

1993 • 38 citations

Differential Activities of CYP1A Isozymes in Hepatic and Intestinal Microsomes of Control and 3-Methylcholanthrene-Induced Rats

2000 • 37 citations

Differential effects of cytokines on the inducible expression of cyp1a1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture*1

1995 • 37 citations

Endotoxic Shock Alters the Pharmacokinetics of Lidocaine and Monoethylglycinexylidide

2002 • 22 citations

The suppression by lipopolysaccharide of cytochrome P450-dependent renal vasodilation in the rat is mediated by nitric oxide

1995 • 18 citations

Failure of Ah Receptor to Mediate Induction of Cytochromes P450 in the CYP1 Family in the Human Hepatoma Line SK-Hep-1

2000 • 14 citations

Mixed-Function Oxidase Activity in Sepsis

1995 • 11 citations

Salutary effects of ATP-MgCl2 on altered hepatocyte signal transduction after hemorrhagic shock

1997 • 5 citations