Rapid Transcriptional Suppression of Rat Cytochrome P450 Genes by Endotoxin Treatment and Its Inhibition by Curcumin
Data up to Jan 2025
Total Citations Per Year
Abstract
References (41)
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
1951 • 319,299 citations
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
1987 • 64,270 citations
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
1987 • 45,673 citations
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
1983 • 11,902 citations
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 • 5,178 citations
Missing Pieces in the NF-κB Puzzle
2002 • 3,560 citations
Nuclei from Rat Liver: Isolation Method That Combines Purity with High Yield
1966 • 1,687 citations
Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)
1995 • 1,352 citations
Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.
1999 • 719 citations
Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity
1999 • 616 citations
Regulation of Cytochromes P450 During Inflammation and Infection
1997 • 477 citations
The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
2003 • 424 citations
Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin
1998 • 399 citations
Ah Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity
1999 • 382 citations
Regulation of cytochrome p450 by inflammatory mediators: why and how?
2001 • 358 citations
Mechanism-based in vitro screening of potential cancer chemopreventive agents
2003 • 335 citations
Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors.
1998 • 262 citations
Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells
1998 • 225 citations
Down‐regulation of human CYP3A4 by the inflammatory signal interleukin 6: molecular mechanism and transcription factors involved
2002 • 212 citations
Systemic administration of the NF-κB inhibitor curcumin stimulates muscle regeneration after traumatic injury
1999 • 202 citations
Haptoglobin, an inflammation-inducible plasma protein
2001 • 176 citations
Evidence for Posttranscriptional Regulation of C/EBPα and C/EBPβ Isoform Expression during the Lipopolysaccharide-Mediated Acute-Phase Response†
1996 • 155 citations
Curcumin, a compound with anti-inflammatory and anti-oxidant properties, down-regulates chemokine expression in bone marrow stromal cells.
1997 • 104 citations
The Vascular Smooth Muscle Type I Angiotensin II Receptor mRNA Is Destabilized by Cyclic AMP-Elevating Agents
1997 • 102 citations
Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450.
1996 • 95 citations
Gene transcription in hepatocytes during the acute phase of a systemic inflammation: from transcription factors to target genes
2001 • 95 citations
Suppression of CYP2C11 Gene Transcription by Interleukin-1 Mediated by NF-κB Binding at the Transcription Start Site
2000 • 91 citations
In Vivo and in Vitro Regulation of Sterol 27-Hydroxylase in the Liver during the Acute Phase Response
2001 • 83 citations
Down-regulation of the expression of three major rat liver cytochrome P450S by endotoxin in vivo occurs independently of nitric oxide production.
1998 • 76 citations
Generation of Truncated C/EBPβ Isoforms by in VitroProteolysis
2000 • 71 citations
Regulation of rabbit cytochrome P450 2E1 expression in HepG2 cells by insulin and thyroid hormone.
1998 • 69 citations
Inhibitory Cross-talk between STAT5b and Liver Nuclear Factor HNF3β
2001 • 65 citations
Transcriptional and post‐transcriptional suppression of P450IIC11 and P450IIC12 by inflammation
1990 • 51 citations
Contribution of Hepatocyte Nuclear Factor-4 to Down-Regulation ofCYP2D6Gene Expression by Nitric Oxide
2002 • 47 citations
Regulation of hepatic cytochrome P450 2C11 via cAMP: implications for down-regulation in diabetes, fasting, and inflammation.
2001 • 46 citations
Hepatocyte Nuclear Factor 4-Mediated Activation of Rat CYP3A1 Gene and Its Modes of Modulation by Apolipoprotein AI Regulatory Protein I and v-ErbA-Related Protein 3
1999 • 45 citations
Promoter Function and the Role of Cytokines in the Transcriptional Regulation of Rabbit CYP2E1 and CYP2E2
2000 • 33 citations
Serine/threonine phosphorylation regulates HNF-4α-dependent redox-mediated iNOS expression in hepatocytes
2003 • 27 citations
The effect of endotoxin on hepatocyte nuclear factor 1 nuclear protein binding: potential implications on CYP2E1 expression in the rat
2001 • 22 citations
Regulation of the HepaticCYP2E1 Gene During Chronic Alcohol Exposure: Lack of an Ethanol Response Element in the Proximal 5′-Flanking Sequence
1997 • 21 citations
Activity of hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β isoforms is differently affected by the inhibition of protein phosphatases 1/2A
2001 • 16 citations