Functional Coexpression of HSV-1 Thymidine Kinase and Green Fluorescent Protein: Implications for Noninvasive Imaging of Transgene Expression

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

1988 • 1,884 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Tumor Induction of VEGF Promoter Activity in Stromal Cells

1998 • 964 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1997 • 945 citations

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.

1996 • 925 citations

Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

1995 • 800 citations

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

1997 • 694 citations

Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes

1997 • 685 citations

Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo

1989 • 417 citations

Imaging the expression of transfected genes in vivo.

1995 • 391 citations

Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.

1998 • 374 citations

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

1995 • 357 citations

Internal initiation of translation in eukaryotes: the picornavirus paradigm and beyond.

1995 • 341 citations

The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos

1991 • 333 citations

Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.

1996 • 333 citations

Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir.

1998 • 303 citations

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.

1994 • 302 citations

Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression.

1997 • 284 citations

Labeling Neural Cells Using Adenoviral Gene Transfer of Membrane-Targeted GFP

1996 • 280 citations

The jellyfish green fluorescent protein: A new tool for studying ion channel expression and function

1995 • 248 citations

Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant.

1994 • 236 citations

The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos.

1991 • 235 citations

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

1997 • 234 citations

Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.

1991 • 216 citations

In vivo imaging of oligonucleotides with positron emission tomography

1998 • 203 citations

Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction.

1997 • 183 citations

Recombinant Retroviruses Pseudotyped With the Vesicular Stomatitis Virus G Glycoprotein Mediate Both Stable Gene Transfer and Pseudotransduction in Human Peripheral Blood Lymphocytes

1997 • 169 citations

The 9L rat brain tumor: Description and application of an animal model

1981 • 166 citations

Experimental Tumor Therapy in Mice Using the Cyclophosphamide-Activating Cytochrome P450 2B1 Gene

1994 • 156 citations

Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1.

1995 • 141 citations

Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts.

1998 • 136 citations

HSV/AAV Hybrid Amplicon Vectors Extend Transgene Expression in Human Glioma Cells

1997 • 132 citations

Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.

1994 • 116 citations

RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma.

1995 • 107 citations

Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins

1998 • 106 citations

Gene Therapy for Brain Tumors

1995 • 106 citations

Restricted beta-galactosidase expression of a hygromycin-lacZ gene targeted to the beta-actin locus and embryonic lethality of beta-actin mutant mice.

1998 • 93 citations

Gene Transfer into Hepatocytes Mediated by Helper Virus-Free HSV/AAV Hybrid Vectors

1997 • 89 citations

The development of in vivo imaging systems to study gene expression

1998 • 88 citations

Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma.

1997 • 68 citations

Herpes Simplex Virus Thymidine Kinase-Green Fluorescent Protein Fusion Gene: New Tool for Gene Transfer Studies and Gene Therapy

1998 • 67 citations

Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats

1994 • 66 citations

Green fluorescent protein as a reporter for retrovirus and helper virus-free HSV-1 amplicon vector-mediated gene transfer into neural cells in culture and in vivo

1997 • 50 citations

Localization of iodine-125-mIP-Des-Met14-bombesin (7-13)NH2 in ovarian carcinoma induced to express the gastrin releasing peptide receptor by adenoviral vector-mediated gene transfer.

1997 • 50 citations

A fluorescence video-endoscopy technique for detection of gene transfer and expression

1998 • 47 citations

Methods for the Construction of Retroviral Vectors and the Generation of High-Titer Producers

2003 • 30 citations

Adenoviral-mediated delivery of gastrin-releasing peptide receptor results in specific tumor localization of a bombesin analogue in vivo.

1997 • 13 citations

Cytokine-Based Gene Therapy for Brain Tumors

1998 • 5 citations

Experimental and Clinical Gene Therapies for Brain Tumors

1998 • 5 citations

Gene Therapy for Neurological Disorders and Brain Tumors

1997 • 4 citations

Tumor Suppressor Gene Therapy for Brain Tumors

1998 • 2 citations