Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

The EGF receptor family as targets for cancer therapy

2000 • 1,339 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein

2000 • 778 citations

Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria

1999 • 642 citations

Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

1998 • 574 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Caspase-dependent Cleavage of Signaling Proteins during Apoptosis

1998 • 420 citations

Bcl-x Promotes the Open Configuration of the Voltage-dependent Anion Channel and Metabolite Passage through the Outer Mitochondrial Membrane

2001 • 356 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

c-Myc in breast cancer.

2000 • 337 citations

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

1999 • 330 citations

Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology

2001 • 309 citations

The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development

2000 • 305 citations

Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN

2001 • 266 citations

Epidermal Growth Factor Protects Epithelial Cells against Fas-induced Apoptosis

1999 • 257 citations

Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin.

2000 • 245 citations

Akt/Protein Kinase B Isoforms Are Differentially Regulated by Epidermal Growth Factor Stimulation

2000 • 210 citations

Epidermal Growth Factor Receptor-dependent Control of Keratinocyte Survival and Bcl-xL Expression through a MEK-dependent Pathway

2001 • 151 citations

Tyrosine kinase signalling in breast cancer: Epidermal growth factor receptor - convergence point for signal integration and diversification

2000 • 151 citations

Inhibition of Mitogen-activated Protein Kinase Kinase Induces Apoptosis of Human Chondrocytes

2001 • 145 citations

The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6

2001 • 141 citations

Defining a role for c-Myc in breast tumorigenesis

1997 • 125 citations

Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation

1998 • 115 citations

EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL

1998 • 112 citations

Two Independent Signaling Pathways Mediate the Antiapoptotic Action of Macrophage-Stimulating Protein on Epithelial Cells

2000 • 108 citations

The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor ?-mediated rat hepatocyte survival and apoptosis

2000 • 103 citations

Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

1999 • 92 citations

Cooperation of TGF alpha and c-Myc in mouse mammary tumorigenesis: coordinated stimulation of growth and suppression of apoptosis.

1996 • 83 citations

Epidermal Growth Factor Impairs the Cytochrome C/Caspase-3 Apoptotic Pathway Induced by Transforming Growth Factorβ in Rat Fetal Hepatocytes Via a Phosphoinositide 3-Kinase–Dependent Pathway

2000 • 80 citations

Role for Bcl-xLin the Regulation of Apoptosis by EGF and TGFβ1 in c-myc Overexpressing Mammary Epithelial Cells

1996 • 75 citations

A Phosphatidylinositol 3-Kinase-dependent Pathway That Differentially Regulates c-Raf and A-Raf

1999 • 73 citations

Altered MAP kinase (ERK1,2) regulation in primary cultures of mammary tumor cells: elevated basal activity and sustained response to EGF

1999 • 58 citations

Role of EGF receptor tyrosine kinase activity in antiapoptotic effect of EGF on mouse hepatocytes

2001 • 50 citations

Cleavage of Mitogen-Activated Protein Kinases in Human Neutrophils Undergoing Apoptosis: Role in Decreased Responsiveness to Inflammatory Cytokines

2001 • 49 citations

A clonal derivative of mammary epithelial cell line COMMA-D retains stem cell characteristics of unique morphological and functional heterogeneity

1988 • 31 citations

Expression of TGF-alpha and EGFR in Breast Cancer and its Relation to Angiogenesis

2000 • 21 citations

Anchorage-Independent Activation of Mitogen-Activated Protein Kinase through Phosphatidylinositol-3 Kinase by Insulin-like Growth Factor I

2000 • 18 citations