Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini Is Targeted by Oncogenes

Cell Death

2004 • 4,599 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

2002 • 763 citations

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

2002 • 699 citations

Tube Morphogenesis

2003 • 657 citations

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

1998 • 625 citations

Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim

2003 • 607 citations

Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo

1995 • 601 citations

The ErbB receptors and their role in cancer progression

2003 • 590 citations

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

2001 • 559 citations

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

2003 • 531 citations

Bim is a suppressor of Myc-induced mouse B cell leukemia

2004 • 485 citations

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

2003 • 466 citations

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal

2002 • 368 citations

Diseases of the breast

2014 • 336 citations

BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo

1999 • 330 citations

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

2001 • 270 citations

Phenotypic Reversion or Death of Cancer Cells by Altering Signaling Pathways in Three-Dimensional Contexts

2002 • 268 citations

Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis

1996 • 256 citations

Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors

2001 • 210 citations

Extracellular Signal-regulated Kinases 1/2 Are Serum-stimulated “BimEL Kinases” That Bind to the BH3-only Protein BimEL Causing Its Phosphorylation and Turnover

2004 • 191 citations

Ras activation in human breast cancer

2000 • 183 citations

Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney

2001 • 182 citations

Nerve Growth Factor (NGF) Down-regulates the Bcl-2 Homology 3 (BH3) Domain-only Protein Bim and Suppresses Its Proapoptotic Activity by Phosphorylation

2002 • 177 citations

Activation of ERK1/2 by ΔRaf-1 : ER* represses Bim expression independently of the JNK or PI3K pathways

2003 • 172 citations

Submandibular gland morphogenesis: Stage-specific expression of TGF-?/EGF, IGF, TGF-?, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-?2, TGF-?3, and EGF-r null mutations

1999 • 156 citations

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

2003 • 152 citations

Role of laminin-1 and TGF-β3 in acinar differentiation of a human submandibular gland cell line (HSG)

1996 • 144 citations

Regulation of Programmed Cell Death by Basement Membranes in Embryonic Development

2000 • 139 citations

Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice

1995 • 132 citations

The ERK-1/2 Signaling Pathway Is Involved in the Stimulation of Branching Morphogenesis of Fetal Mouse Submandibular Glands by EGF

2000 • 121 citations

Role of Bim in the survival pathway induced by Raf in epithelial cells

2003 • 114 citations

Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F

1999 • 102 citations

Investigation of the Mek-MAP kinase-Rsk pathway in human breast cancer.

1999 • 94 citations

Influence of microenvironment on mammary epithelial cell survival in primary culture

1999 • 68 citations

Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice.

1996 • 57 citations

Bim Is an Apoptosis Sensor That Responds to Loss of Survival Signals Delivered by Epidermal Growth Factor but Not Those Provided by Integrins

2004 • 40 citations

Estrogen and progesterone receptor and c-erbB-2 oncoprotein analysis in pure in situ breast carcinoma: an immunohistochemical study.

1993 • 31 citations