Junction genetics

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis

1988 • 1,626 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

Cardiac Malformation in Neonatal Mice Lacking Connexin43

1995 • 1,242 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

CONNEXINS, CONNEXONS, AND INTERCELLULAR COMMUNICATION

1996 • 1,180 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

Connexin43: a protein from rat heart homologous to a gap junction protein from liver.

1987 • 1,111 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

1995 • 994 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

1987 • 906 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

1988 • 810 citations

Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes

1991 • 771 citations

The engrailed locus of drosophila: Structural analysis of an embryonic transcript

1985 • 735 citations

Molecular cloning of cDNA for rat liver gap junction protein.

1986 • 715 citations

Lack of β-catenin affects mouse development at gastrulation

1995 • 700 citations

Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines.

1990 • 697 citations

Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of drosophila

1995 • 681 citations

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1990 • 675 citations

crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia

1990 • 669 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Characterization and cloning of fasciclin III: A glycoprotein expressed on a subset of neurons and axon pathways in Drosophila

1987 • 545 citations

Heteromultimerization and NMDA Receptor-Clustering Activity of Chapsyn-110, a Member of the PSD-95 Family of Proteins

1996 • 539 citations

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

1995 • 498 citations

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin

1990 • 474 citations

Notch is required for successive cell decisions in the developing Drosophila retina.

1989 • 473 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

Morphoregulatory molecules

1988 • 460 citations

COMMENTARY: Role of connexin genes in growth control

1996 • 456 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

1994 • 452 citations

The Development of Cellular Junctions in the Drosophila Embryo

1994 • 449 citations

The emergence of order in the Drosophila pupal retina

1989 • 439 citations

Cadherins

1992 • 437 citations

A Drosophila Homolog of Cadherin Associated with Armadillo and Essential for Embryonic Cell-Cell Adhesion

1994 • 435 citations

Calcium-dependent cell-cell adhesion molecules (cadherins): subclass specificities and possible involvement of actin bundles.

1987 • 432 citations

Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

1996 • 430 citations

Neuronal development in the drosophila retina: Monoclonal antibodies as molecular probes

1984 • 430 citations

Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors.

1986 • 427 citations

wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate

1992 • 425 citations

wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo

1994 • 423 citations

Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia.

1996 • 422 citations

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

1993 • 421 citations

A Drosophila Neurexin Is Required for Septate Junction and Blood-Nerve Barrier Formation and Function

1996 • 419 citations

Regulation of Synapse Structure and Function by the Drosophila Tumor Suppressor Gene dlg

1996 • 411 citations

Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.

1994 • 405 citations

Early events in insect neurogenesis

1985 • 403 citations

The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.

1992 • 385 citations

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

1988 • 383 citations

Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice.

1996 • 382 citations

Molecular organization of the uvomorulin-catenin complex.

1992 • 378 citations

Mutations of theConnexin43Gap-Junction Gene in Patients with Heart Malformations and Defects of Laterality

1995 • 376 citations

Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

1990 • 374 citations

shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia.

1996 • 373 citations

Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin.

1991 • 366 citations

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

1994 • 365 citations

The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

1996 • 353 citations

Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies.

1992 • 351 citations

Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the γ2 subunit of nicein/kalinin (LAMININ–5)

1994 • 339 citations

Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions.

1996 • 335 citations

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.

1996 • 335 citations

PDZs and Receptor/Channel Clustering: Rounding Up the Latest Suspects

1996 • 322 citations

The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats

1987 • 317 citations

The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

1992 • 312 citations

Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated.

1991 • 310 citations

Mutations in the γ2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa

1994 • 309 citations

A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene

1994 • 304 citations

The drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure

1994 • 301 citations

Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules.

1988 • 301 citations

Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis.

1996 • 300 citations

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

1991 • 298 citations

Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function.

1991 • 297 citations

Protein–protein interactions: PDZ domain networks

1996 • 292 citations

An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling.

1996 • 292 citations

Zygotic Drosophila E-cadherin expression is required for processes of dynamic epithelial cell rearrangement in the Drosophila embryo.

1996 • 289 citations

Tissue Distribution of the Four Gene Products of the Plasma Membrane Ca2+ Pump

1995 • 289 citations

Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin.

1985 • 286 citations

SH3 — an abundant protein domain in search of a function

1992 • 280 citations

The genetic control of wing development inDrosophila

1940 • 279 citations

Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila

1987 • 279 citations

Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos

1987 • 271 citations

The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments

1987 • 263 citations

Phenocopies induced with antisense RNA identify the wingless gene

1987 • 259 citations

The function of PS integrins during Drosophila embryogenesis

1989 • 256 citations

Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates.

1988 • 251 citations

Phosphorylation of the Drosophila Adherens Junction Protein Armadillo: Roles for Wingless Signal and Zeste-white 3 Kinase

1994 • 251 citations

Clustering Membrane Proteins: It's All Coming Together with the PSD-95/SAP90 Protein Family

1996 • 246 citations

Secretion and movement of wingless protein in the epidermis of the Drosophila embryo

1991 • 244 citations

The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits.

1988 • 235 citations

Crumbs, a Component of the Apical Membrane, Is Required for Zonula Adherens Formation in Primary Epithelia ofDrosophila

1996 • 229 citations

Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development

1993 • 222 citations

ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions

1993 • 214 citations

Fasciclin III: A novel homophilic adhesion molecule in Drosophila

1989 • 211 citations

New functions for gap junctions

1995 • 203 citations

Cell adhesion and signal transduction: the Armadillo connection

1995 • 200 citations

A missense mutation in type VII collagen in two affected siblings with recessive dystrophic epidermolysis bullosa

1993 • 199 citations

The distribution of PS integrins, laminin A and F-actin during key stages in Drosophila wing development

1993 • 195 citations

Null mutations of connexin32 in patients with X-linked Charcot-Marie-Tooth disease

1994 • 191 citations

The life cycle of a connexin: Gap junction formation, removal, and degradation

1996 • 187 citations

The Drosophila genes crumbs and stardust are involved in the biogenesis of adherens junctions

1996 • 176 citations

Mutations in the connexin 32 gene in X-linked dominant Charcot- Marie - Tooth disease (CMTX1)

1994 • 175 citations

The bride of sevenless and sevenless interaction: Internalization of a transmembrane ligand

1992 • 172 citations

Tiggrin, a novel Drosophila extracellular matrix protein that functions as a ligand for Drosophila αPS2βPS integrins

1994 • 170 citations

Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3

1990 • 161 citations

Identification of a Drosophila homologue of alpha-catenin and its association with the armadillo protein.

1993 • 161 citations

Molecular genetics of the cutaneous basement membrane zone. Perspectives on epidermolysis bullosa and other blistering skin diseases.

1992 • 158 citations

An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily.

1990 • 154 citations

Cell-cell interaction and polarity of epithelial cells: Specific perturbation using a monoclonal antibody

1983 • 153 citations

The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development.

1989 • 150 citations

Requirement for integrins during Drosophila wing development

1989 • 149 citations

cDNAs of cell adhesion molecules of different specificity induce changes in cell shape and border formation in cultured S180 cells.

1990 • 147 citations

The product of the Drosophila segment polarity gene Armadillo is part of a multi-protein complex resembling the vertebrate adherens junction

1993 • 146 citations

Phylogenetic relationships within the invertebrata in relation to the structure of septate junctions and the development of ‘occluding’ junctional types

1982 • 145 citations

Notch: Neurogenesis is only part of the picture

1993 • 145 citations

Cx43 gap junction gene expression and gap junctional communication in mouse neural crest cells

1997 • 143 citations

expanded: a gene involved in the control of cell proliferation in imaginal discs

1993 • 141 citations

Of mice and men: Genetic skin diseases of keratin

1992 • 135 citations

Fasciclin III as a synaptic target recognition molecule in Drosophila

1995 • 134 citations

The Notch Locus and the Cell Biology of Neuroblast Segregation

1991 • 131 citations

Transmembrane molecular assemblies regulated by the greater cadherin family

1991 • 128 citations

Neural differentiation, NCAM-mediated adhesion, and gap junctional communication in neuroectoderm. A study in vitro.

1988 • 126 citations

Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos

1993 • 125 citations

The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7

1987 • 124 citations

eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling.

1996 • 122 citations

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain.

1996 • 118 citations

The function of PS integrins in Drosophila wing morphogenesis

1989 • 115 citations

Localization of proteins to the apico-lateral junctions ofDrosophila epithelia

1997 • 114 citations

Single amino acid substitutions in EGF-like elements of notch and delta modify drosophila development and affect cell adhesion in vitro

1992 • 113 citations

Molecular genetics of epidermolysis bullosa

1992 • 110 citations

Phenotypic and developmental analysis of mutations at thecrumbs locus, a gene required for the development of epithelia inDrosophila melanogaster

1990 • 108 citations

Requirements for integrins during Drosophila development

1990 • 107 citations

Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with Gαi2

1996 • 104 citations

Molecular mechanisms of epithelial cell junctions : from development to disease

1994 • 99 citations

Microtubule polarities indicate that nucleation and capture of microtubules occurs at cell surfaces in Drosophila.

1989 • 99 citations

Integrins hold Drosophila together

1993 • 97 citations

PS2 Integrin Requirements in Drosophila Embryo and Wing Morphogenesis

1993 • 95 citations

A histological and ultrastructural analysis of developmental defects produced by the mutation, lethal(1)myospheroid, in Drosophila melanogaster

1981 • 95 citations

CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development

1993 • 93 citations

Passover: A gene required for synaptic connectivity in the giant fiber system of Drosophila

1993 • 93 citations

Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton.

1996 • 86 citations

Regulating Cell Proliferation—As Easy as APC

1996 • 86 citations

Apical junctions and cell signalling in epithelia

1993 • 84 citations

A new junctional structure in the epithelia of insects of the order dictyoptera

1972 • 84 citations

Nonequivalent requirements for PS1 and PS2 integrin at cell attachments in Drosophila: genetic analysis of the αPS1 integrin subunit

1995 • 83 citations

Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2.

1994 • 82 citations

Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions

1992 • 77 citations

The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1.

1996 • 74 citations

Blocking gap junctional intercellular communication in myoblasts inhibits myogenin and MRF4 expression

1997 • 73 citations

Not just glue: cell-cell junctions as cellular signaling centers

1995 • 68 citations

Isolation and characterisation of arthropod gap junctions

1984 • 67 citations

Localization of DER and the pattern of cell divisions in wild-type and Ellipse eye imaginal discs

1992 • 67 citations

Complex function and expression of Delta during Drosophila oogenesis.

1993 • 65 citations

Developmental analysis of Drosophila position-specific antigens

1985 • 57 citations

Zygotic expression of the connexin43 gene supplies subunits for gap junction assembly during mouse preimplantation development

1991 • 57 citations

Expression of a connexin 43/beta-galactosidase fusion protein inhibits gap junctional communication in NIH3T3 cells.

1995 • 57 citations

Expanded functions in the apical cell domain to regulate the growth rate of imaginal discs

1997 • 56 citations

A monoclonal antibody specific for diploid epithelial cells in Drosophila

1980 • 55 citations

Ductin – a proton pump component, a gap junction channel and a neurotransmitter release channel

1995 • 55 citations

Rates of diffusion of fluorescent molecules via cell-to-cell membrane channels in a developing tissue.

1985 • 53 citations

Molecular organization of gap junction membrane channels

1996 • 52 citations

Cloning and characterization of αPS1, a novel Drosophila melanogaster integrin

1993 • 51 citations

Localizing the adhesive and signaling functions of plakoglobin

1997 • 50 citations

Expanded, a negative regulator of cell proliferation in drosophila, shows homology to the NF2 tumor suppressor

1993 • 49 citations

Testing the Agrin Hypothesis

1996 • 48 citations

Is the gap junction channel - The Connexon - made of connexin or ductin?

1993 • 46 citations

Evidence that the 16 kDa proteolipid (subunit c) of the vacuolar H+-ATPase and ductin from gap junctions are the same polypeptide in Drosophila and Manduca: molecular cloning of the Vha16k gene from Drosophila

1994 • 43 citations

Patterns of dye coupling in the imaginal wing disk of Drosophila melanogaster

1985 • 39 citations

The l(1)ogre gene of Drosophila melanogaster is expressed in postembryonic neuroblasts

1992 • 37 citations

Drosophila PS integrins recognize vertebrate vitronectin and function as cell-substratum adhesion receptors in vitro

1991 • 32 citations

Disposition and Orientation of Ductin (DCCD-Reactive Vacuolar H+-ATPase Subunit) in Mammalian Membrane Complexes

1993 • 31 citations

The arthropod gap junction and pseudo-gap junction: Isolation and preliminary biochemical analysis

1988 • 25 citations

Isolation and characterization of gap junctions from Drosophila melanogaster

1989 • 24 citations

Role of the PS integrins in Drosophila development

1995 • 16 citations

Distribution of PASII/PMP22 and connexin 32 proteins in the peripheral nervous system

1995 • 14 citations

Junctional types in the tissues of an onychophoran: The apparent lack of gap and tight junctions in Peripatus

1994 • 11 citations

Malcolm E. Finbow, Michael Harrison and Phillip Jones reply

1995 • 1 citations