Adenoviral-mediated gene transfer to enhance neuronal survival, growth, and regeneration

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

1997 • 3,081 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors

1990 • 1,232 citations

Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes

1991 • 1,171 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

1995 • 976 citations

Construction of adenovirus vectors through Cre-lox recombination

1997 • 807 citations

Manipulation of Adenovirus Vectors

2003 • 780 citations

Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function

1996 • 764 citations

Regeneration of adult axons in white matter tracts of the central nervous system

1997 • 747 citations

An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain

1993 • 746 citations

Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors

1995 • 723 citations

A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal

1996 • 717 citations

Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain

1995 • 659 citations

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity

1998 • 654 citations

Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors

1996 • 640 citations

Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy

1997 • 637 citations

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

1994 • 627 citations

MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

1994 • 619 citations

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

1988 • 606 citations

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.

1991 • 591 citations

A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

1993 • 588 citations

A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase.

1996 • 572 citations

Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats

1995 • 572 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Transfer of a foreign gene into the brain using adenovirus vectors

1993 • 538 citations

The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth.

1994 • 449 citations

Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization.

1994 • 418 citations

Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells

1998 • 415 citations

Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors

1993 • 387 citations

Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy

1996 • 379 citations

Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion.

1995 • 377 citations

Neurotrophic Factors Increase Axonal Growth after Spinal Cord Injury and Transplantation in the Adult Rat

1997 • 360 citations

A placebo‐controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis

1996 • 340 citations

Promoter Attenuation in Gene Therapy: Interferon-γand Tumor Necrosis Factor-αInhibit Transgene Expression

1997 • 317 citations

Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease

1997 • 301 citations

Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth

1990 • 299 citations

Expression of bcl-2 From a Defective Herpes Simplex Virus–1 Vector Limits Neuronal Death in Focal Cerebral Ischemia

1995 • 297 citations

Adenovirus gene transfer causes inflammation in the brain

1995 • 283 citations

Long–term hepatic adenovirus–mediated gene expression in mice following CTLA4Ig administration

1995 • 281 citations

In Vitro and In Vivo Biology of Recombinant Adenovirus Vectors with E1, E1/E2A, or E1/E4 Deleted

1998 • 275 citations

Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo.

1995 • 258 citations

Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

1997 • 254 citations

Attenuation of Stroke Size in Rats Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist in Brain

1995 • 245 citations

Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors

1997 • 223 citations

Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo

1996 • 214 citations

Motoneuron death after sciatic nerve section in newborn rats

1984 • 213 citations

Reactive microglia in cerebral ischaemia: an early mediator of tissue damage?

1995 • 208 citations

Inflammatory Gene Expression in Cerebral Ischemia and Trauma

1997 • 207 citations

Effect of the E4 region on the persistence of transgene expression from adenovirus vectors

1997 • 195 citations

A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging

1997 • 194 citations

Glial Cell Line‐Derived Neurotrophic Factor Exerts Neurotrophic Effects on Dopaminergic Neurons In Vitro and Promotes Their Survival and Regrowth After Damage by 1‐Methyl‐4‐Phenylpyridinium

1996 • 181 citations

Immune Responses to Reporter Proteins and High Viral Dose Limit Duration of Expression with Adenoviral Vectors: Comparison of E2a Wild Type and E2a Deleted Vectors

1997 • 173 citations

Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons

1997 • 169 citations

Neuronal Apoptosis: Current Understanding of Molecular Mechanisms and Potential Role in Ischemic Brain Injury

1995 • 168 citations

Interferon-γ Inhibits Transgene Expression Driven by SV40 or CMV Promoters but Augments Expression Driven by the Mammalian MHC I Promoter

1995 • 163 citations

Immune responses to adenovirus vectors in the nervous system

1996 • 161 citations

Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinsonʼs disease

1994 • 160 citations

Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses

1997 • 160 citations

Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury

1997 • 159 citations

Quantitative Comparison of the Transient Rescue Effects of Neurotrophic Factors on Axotomized Motoneurons In Vivo

1995 • 149 citations

Transplants and Neurotrophic Factors Prevent Atrophy of Mature CNS Neurons after Spinal Cord Injury

1998 • 142 citations

Viral vectors, tools for gene transfer in the nervous system

1998 • 142 citations

Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver.

1996 • 136 citations

Persistent transgene expression in mouse liver following in vivo gene transfer with a ΔE1/ΔE4 adenovirus vector

1997 • 136 citations

Herpes Simplex Viral Vectors Expressing Bcl-2 Are Neuroprotective When Delivered After a Stroke

1997 • 135 citations

Immunohistochemical localization of neurocan and L1 in the formation of thalamocortical pathway of developing rats

1997 • 128 citations

CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses.

1995 • 125 citations

Second–generation adenovirus vectors

1996 • 121 citations

Targeted Transduction of CNS Neurons with Adenoviral Vectors Carrying Neurotrophic Factor Genes Confers Neuroprotection That Exceeds the Transduced Population

1997 • 117 citations

Functions of brain chondroitin sulfate proteoglycans during developments: interactions with adhesion molecules.

1996 • 116 citations

Adenovirus-mediated gene transfer and expression of human β-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VII mice

1997 • 114 citations

Lack of persistence of E1- recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs.

1996 • 108 citations

Prevention of motoneuron death by adenovirus-mediated neurotrophic factors

1997 • 106 citations

Fetal Spinal Cord Transplants Support Growth of Supraspinal and Segmental Projections after Cervical Spinal Cord Hemisection in the Neonatal Rat

1998 • 104 citations

Amelioration of ischaemia-induced neuronal death in the rat striatum by NGF-secreting neural stem cells

1998 • 99 citations

Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease

1997 • 96 citations

Role of T cells in inflammation caused by adenovirus vectors in the brain.

1996 • 96 citations

Long-term gene therapy in the CNS: Reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin

1997 • 94 citations

Transformation by and Oncogenicity of Human Adenoviruses

1984 • 94 citations

Transient gene transfer to neurons and glia: Analysis of adenoviral vector performance in the CNS and PNS

1997 • 90 citations

Adenovirus in the brain: recent advances of gene therapy for neurodegenerative diseases

1998 • 86 citations

Adenovirus Infections in Humans

1984 • 78 citations

Application of recombinant adenovirus for in vivo gene delivery to spinal cord

1997 • 75 citations

Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion.

1996 • 68 citations

Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host.

1996 • 64 citations

Continuous renewal of the axonal pathway sensor apparatus by insertion of new sensor molecules into the growth cone membrane

1996 • 63 citations

Adenovirus-mediated gene transfer to the brain: methodological assessment

1997 • 61 citations

Intracranial Administration of Adenovirus Expressing HSV-TK in Combination with Ganciclovir Produces a Dose-Dependent, Self-Limiting Inflammatory Response

1997 • 61 citations

Gene Transfer to Cerebral Blood Vessels After Subarachnoid Hemorrhage

1997 • 59 citations

Nondepleting Anti-CD4 Antibody Treatment Prolongs Lung-Directed E1-Deleted Adenovirus-Mediated Gene Expression in Rats

1996 • 55 citations

Retrograde transfer of replication deficient recombinant adenovirus vector in the central nervous system for tracing studies

1995 • 54 citations

Role of growth factors in degeneration and regeneration in the central nervous system; clinical experiences with NGF in Parkinson's and Alzheimer's diseases

1994 • 52 citations

Adenoviral vector-directed expression of neurotrophin-3 in rat dorsal root ganglion explants results in a robust neurite outgrowth response

1997 • 48 citations

Direct Intracerebral Nerve Growth Factor Gene Transfer Using a Recombinant Adenovirus: Effect on Basal Forebrain Cholinergic Neurons during Aging

1996 • 46 citations

Neurite Outgrowth on Non‐permissive Substrates In Vitro is Enhanced by Ectopic Expression of the Neural Adhesion Molecule L1 by Mouse Astrocytes

1996 • 44 citations

Astrocytes Infected with Replication-Defective Adenovirus Containing a Secreted Form of CNTF or NT3 Show Enhanced Support of Neuronal Populationsin Vitro

1996 • 44 citations

In vivo adenovirus-mediated gene transfer and the expression in ischemic and reperfused rat brain

1997 • 43 citations

Adenoviral vector-mediated expression of B-50/GAP-43 induces alterations in the membrane organization of olfactory axon terminals in vivo.

1997 • 41 citations

Adenoviral gene transfer into the normal and injured spinal cord: enhanced transgene stability by combined administration of temperature-sensitive virus and transient immune blockade

1998 • 39 citations

Adenoviral Vector-Mediated Expression of B-50/GAP-43 Induces Alterations in the Membrane Organization of Olfactory Axon TerminalsIn Vivo

1997 • 37 citations

Restoration of hexosaminidase A activity in human Tay-Sachs fibroblasts via adenoviral vector-mediated gene transfer.

1996 • 36 citations

Retinal Functional Change Caused by Adenoviral Vector-Mediated Transfection of LacZ Gene

1998 • 35 citations

Toxicity of Replication-Defective Adenoviral Recombinants in Dissociated Cultures of Nervous Tissue

1996 • 32 citations

In Vivo Bcl-2 Oncogene Neuronal Expression in the Rat Spinal Cord

1998 • 31 citations

Adenovirus-mediated transfer of a functional GAD gene into nerve cells: potential for the treatment of neurological diseases

1997 • 26 citations

The Architecture of Adenoviruses

1984 • 25 citations

Electrophysiological Analysis of Dorsal Root Ganglion Neurons Pre- and Post-Coexpression of Green Fluorescent Protein and Functional 5-HT₃Receptor

1997 • 25 citations

Grafts of genetically modified fibroblasts expressing neural cell adhesion molecule L1 into transected spinal cord of adult rats

1995 • 23 citations

Rotational behavior produced by adenovirusmediated gene transfer of dopamine D2 receptor into rat striatum

1997 • 22 citations

Adenovirus-mediated gene transfer in neurons: construction and characterization of a vector for heterologous expression of the axonal cell adhesion molecule axonin-1

1997 • 22 citations

Hypoxanthine-guanine phosphoribosyltransferase (HPRT) expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer

1996 • 12 citations

Gene Therapy for Ischemic Stroke

1998 • 3 citations