Herpes Simplex Viral Vectors Expressing Bcl-2 Are Neuroprotective When Delivered After a Stroke

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Neural apoptosis

1995 • 464 citations

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1996 • 311 citations

Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat

1992 • 309 citations

Expression of bcl-2 From a Defective Herpes Simplex Virus–1 Vector Limits Neuronal Death in Focal Cerebral Ischemia

1995 • 297 citations

Protein synthesis in the cat brain after prolonged cerebral ischemia

1971 • 184 citations

Defective Herpes Simplex Virus Vectors Expressing the Rat Brain Stress‐Inducible Heat Shock Protein 72 Protect Cultured Neurons from Severe Heat Shock

1997 • 123 citations

BCL-2 blocks glutamate toxicity in neural cell lines

1993 • 99 citations

Bcl-2 Prevents Killing of Neuronal Cells by Glutamate but Not by Amyloid β Protein

1993 • 98 citations

Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss.

1995 • 95 citations

Overexpression of the Glucose Transporter Gene with a Herpes Simplex Viral Vector Protects Striatal Neurons against Stroke

1996 • 94 citations

Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor‐mediated neuronal death

1990 • 92 citations

Herpes simplex virus vector system: analysis of its in vivo and in vitro cytopathic effects

1995 • 56 citations

A Herpes Simplex Virus Vector Overexpressing the Glucose Transporter Gene Protects the Rat Dentate Gyrus from an Antimetabolite Toxin

1996 • 34 citations

Narrow temporal therapeutic window for NMDA antagonist protection against focal cerebral ischaemia

1995 • 25 citations