Axotomy‐induced neuronal death during development

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

1991 • 2,763 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

The Axon Reaction: A Review of the Principal Features of Perikaryal Responses to Axon Injury

1971 • 1,112 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Fluoro-gold: a new fluorescent retrograde axonal tracer with numerous unique properties

1986 • 881 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

The changing scene of neurotrophic factors

1991 • 827 citations

Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons

1988 • 657 citations

Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

1989 • 624 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

1992 • 559 citations

A consideration of neural counting methods

1992 • 542 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

1990 • 529 citations

A NERVE GROWTH-STIMULATING FACTOR ISOLATED FROM SARCOM AS 37 AND 180

1954 • 513 citations

Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor

1991 • 448 citations

Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF)

1989 • 429 citations

Distribution of neuronal receptors for nerve growth factor in the rat

1986 • 398 citations

The effects of wing bud extirpation on the development of the central nervous system in chick embryos

1934 • 389 citations

Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization

1990 • 387 citations

Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice

1990 • 364 citations

PDGF A-chain gene is expressed by mammalian neurons during development and in maturity

1991 • 360 citations

Regression versus peripheral control of differentiation in motor hypoplasia

1958 • 350 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Morphological response of axotomized septal neurons to nerve growth factor

1988 • 323 citations

Basic fibroblast growth factor promotes the survival and development of mesencephalic neurons in culture

1989 • 318 citations

Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally occurring and induced cell loss during development

1978 • 318 citations

Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury

1987 • 316 citations

Morphometric analysis of rat superior cervical ganglion after axotomy and nerve growth factor treatment

1976 • 311 citations

Death of some dorsal root ganglion neurons and plasticity of others following sciatic nerve section in adult and neonatal rats

1989 • 302 citations

Keeping track of neurotrophin receptors

1991 • 297 citations

Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target Neurons

1990 • 282 citations

Neurotrophic molecules

1989 • 270 citations

Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system

1987 • 268 citations

Ultrastructural differences during embryonic cell death in normal and peripherally deprived ciliary ganglia.

1976 • 266 citations

The effects of nerve growth factor and its antiserum on the postnatal development and survival after injury of sensory neurons in rat dorsal root ganglia

1984 • 265 citations

Dependence of postnatal motoneurones on their targets: review and hypothesis

1992 • 245 citations

Selective dependence of mammalian dorsal root ganglion neurons on nerve growth factor during embryonic development

1992 • 240 citations

Nerve growth factor prevents toxic neuropathy in mice

1991 • 236 citations

Synapse formation during embryogenesis on ganglion cells lacking a periphery

1974 • 235 citations

Retrograde cell changes in medial septum and diagonal band following fimbria-fornix transection: Quantitative temporal analysis

1986 • 235 citations

The role of NGF in sensory neurons in vivo

1986 • 233 citations

Motor localization and the effects of nerve injury on the ventral horn cells of the spinal cord.

1946 • 229 citations

Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse

1990 • 227 citations

Neural tissue transplants rescue axotomized rubrospinal cells from retrograde death

1986 • 227 citations

Relation of target encounter and neuronal death to nerve growth factor responsiveness in the developing mouse trigeminal ganglion

1984 • 225 citations

Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment

1988 • 213 citations

Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS

1992 • 213 citations

Motoneuron death after sciatic nerve section in newborn rats

1984 • 213 citations

Changes in cytoskeletal proteins in the rat facial nucleus following axotomy

1988 • 205 citations

Cell death of motoneurons in the chick embryo spinal cord. IX. The loss of motoneurons following removal of afferent inputs

1984 • 202 citations

Cell death of motoneurons in the chick embryo spinal cord. III. The differentiation of motoneurons prior to their induced degeneration following limb‐bud removal

1978 • 200 citations

Nerve growth factor (NGF) reverses axotomy-induced decreases in choline acetyltransferase, NGF receptor and size of medial septum cholinergic neurons

1989 • 197 citations

Afferent influences on the development of the brain stem auditory nuclei of the chicken: Otocyst ablation

1979 • 190 citations

Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates

1991 • 190 citations

A quantitative comparison of the reactions of retinal ganglion cells to optic nerve crush in neonatal and adult mice

1984 • 185 citations

Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain

1991 • 184 citations

Retrograde axonal transport of specific macromolecules as a tool for characterizing nerve terminal membranes

1979 • 183 citations

Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey

1990 • 170 citations

The spatial and temporal pattern of beta NGF receptor expression in the developing chick embryo.

1985 • 163 citations

Anatomical Plasticity and Sparing of Function After Spinal Cord Damage in Neonatal Cats

1982 • 154 citations

Naturally-occurring neuron death in the ciliary ganglion of the chick embryo following removal of preganglionic input: evidence for the role of afferents in ganglion cell survival

1987 • 154 citations

Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects

1988 • 151 citations

Cell death of motoneurons in the chick embryo spinal cord. VI. Reduction of naturally occurring cell death in the thoracolumbar column of terni by nerve growth factor

1982 • 147 citations

Brain macrophages and microglia respond differently to lesions of the developing and adult visual system

1991 • 133 citations

Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons

1988 • 127 citations

Axon reaction in dorsal motor vagal and hypoglossal neurons of the adult rat. light microscopy and RNA‐cytochemistry

1980 • 124 citations

Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero

1992 • 123 citations

Quantitative in vitro studies on the nerve growth factor (NGF) requirement of neurons

1977 • 120 citations

Neuronal death during development in the isthmo‐optic nucleus of the chick: Sustaining role of afferents from the tectum

1985 • 117 citations

Axotomy Mimicked by Localized Colchicine Application

1972 • 116 citations

Changes in the magnocellular portion of the red nucleus following thoracic hemisection in the neonatal and adult rat

1976 • 111 citations

Treatment with 6-hydroxydopamine and colchicine decreases nerve growth factor levels in sympathetic ganglia and increases them in the corresponding target tissues

1985 • 111 citations

Response of septal cholinergic neurons to axotomy

1987 • 108 citations

Expression of choline acetyltransferase and nerve growth factor receptor within hypoglossal motoneurons following nerve injury

1991 • 107 citations

The dependence of motoneurons on their target muscle during postnatal development of the mouse

1990 • 104 citations

Effect of sciatic neurectomy on neuronal number and size distribution in the L7 ganglion of kittens

1981 • 104 citations

Target dependence of hypoglossal motor neurons during development and in maturity

1989 • 102 citations

Fibroblast growth factor receptor‐bearing neurons in the CNS: Identification by receptor‐mediated retrograde transport

1991 • 100 citations

A method for specific transmitter identification of retrogradely labeled neurons: Immunofluorescence combined with fluorescence tracing

1984 • 97 citations

Administration of testosterone attenuates neuronal loss following axotomy in the brain-stem motor nuclei of female rats

1989 • 94 citations

Role of target tissue in regulating the development of retinal ganglion cells in the albino rat: Effects of kainate lesions in the superior colliculus

1986 • 93 citations

Cell death of corticospinal neurons is induced by axotomy before but not after innervation of spinal targets

1990 • 83 citations

Persistence of fluoro-gold following degeneration of labeled motoneurons is due to phagocytosis by microglia and macrophages

1991 • 77 citations

Endocytosis and autophagy in dying neurons: An ultrastructural study in chick embryos

1989 • 76 citations

Hormonal control of neuron number in sexually dimorphic spinal nuclei of the rat: I. Testosterone-regulated death in the dorsolateral nucleus

1989 • 72 citations

Differences in horseradish peroxidase labeling of sensory, motor and sympathetic neurons following chronic axotomy of the rat sural nerve

1986 • 71 citations

Differential neuronal survival in the avian ciliary ganglion after chronic acetylcholine receptor blockade

1987 • 64 citations

Loss of Retinal X-cells in Cats with Neonatal or Adult Visual Cortex Damage

1982 • 64 citations

Cell death and changes in the retrograde transport of horseradish peroxidase in rubrospinal neurons following spinal cord hemisection in the adult rat

1983 • 63 citations

Neurotropic influence of mesenchymal limb target tissue on spinal cord neurite growth in vitro

1981 • 63 citations

Anatomical consequences of neonatal infraorbital nerve transection upon the trigeminal ganglion and vibrissa follicle nerves in the adult rat

1988 • 61 citations

Redirected growth of pyramidal tract axons following neonatal pyramidotomy in cats

1987 • 60 citations

Target dependency of developing motoneurons inXenopus laevis

1981 • 60 citations

Neuronal and Nonneuronal Influences on Retinal Ganglion Cell Survival, Axonal Regrowth, and Connectivity after Axotomy^a

1991 • 59 citations

Target-dependent hormonal control of neuron size in the rat spinal nucleus of the bulbocavernosus

1991 • 57 citations

Peripheral nerve injury down‐regulates CNTF expression in adult rat sciatic nerves

1992 • 54 citations

Hormonal control of neuron number in sexually dimorphic spinal nuclei of the rat: III. Differential effects of the androgen dihydrotestosterone

1989 • 52 citations

Lack of evidence for cell death among avian spinal cord interneurons during normal development and following removal of targets and afferents

1991 • 50 citations

Transneuronal retrograde degeneration in the cat retina following neonatal ablation of visual cortex

1981 • 49 citations

Sex difference in neuronal loss induced by axotomy in the rat brain stem motor nuclei

1988 • 47 citations

A morphometric study of mouse trigeminal ganglion after unilateral destruction of vibrissae follicles at birth

1981 • 44 citations

Abrupt loss of dependence of retinopetal neurons on their target cells, as shown by intraocular injections of kainate in chick embryos

1987 • 43 citations

Androgen increases the number of cells in fetal mouse spinal cord cultures: implications for motoneuron survival

1989 • 43 citations

Axon and neuron numbers after forelimb amputation in neonatal rats

1986 • 41 citations

Perisomatic changes in the maturing hypoglossal nucleus after axon injury

1982 • 40 citations

Ultrastructural sequence of embryonic cell death in normal and peripherally deprived trochlear nucleus

1978 • 38 citations

Critical period for the marked loss of retinal X-cells following visual cortex damage in cats

1984 • 37 citations

Retrograde transport of Fluoro-Gold in corticospinal and rubrospinal neurons 10 and 20 weeks after T-9 spinal cord transection

1990 • 36 citations

The response of rubrospinal neurons to axotomy in the adult opossum, didelphis virginiana

1990 • 35 citations

Changes in the nuclei of dying neurons as studied with thymidine autoradiography

1989 • 27 citations

Loss of neurons in the red nucleus after spinal cord transection

1988 • 26 citations

Absence of Nerve – muscle Interaction Influences the Survival of Developing Motoneurons

1991 • 23 citations

Embryonic development and survival of brachial motoneurons projecting to muscleless chick wings

1991 • 21 citations

A LIGHT AND ELECTRON MICROSCOPIC STUDY OF AXON REACTION IN THE RED NUCLEUS OF THE RAT FOLLOWING CERVICAL AND THORACIC LESIONS

1977 • 21 citations

Naturally occurring cell death and differentiation of developing spinal motoneurons following axotomy

1989 • 21 citations

Effects of advancing age on the central response of rat facial neurons to axotomy: Light microscope morphometry

1990 • 20 citations

Ultrastructural changes in the nucleolus of facial motor neurons following axotomy during an early critical period in development

1991 • 18 citations

Combined effects of deafferentation and de-efferentation on isthmo-optic neurons during the period of their naturally occurring cell death

1988 • 17 citations

Effect on the rat hypoglossal nucleus of vinblastine and colchicine applied to the intact or transected hypoglossal nerve

1988 • 17 citations

Survival of the ganglion cell population in the rabbit retina following neonatal visual cortex ablation

1985 • 11 citations

Intrasomatic changes in the maturing hypoglossal nucleus after axon injury

1983 • 10 citations

Ultrastructural observations on retrograde degeneration in neuronal perikarya of the hypoglossal nucleus

1973 • 9 citations

Chapter 25 Neuronal responses to injury and aging: lessons from animal models

1990 • 7 citations

Stage‐dependent spontaneous frog dorsal root ganglion neuritogenesis on polylysine in vitro

1990 • 4 citations