CD28-independent Induction of T Helper Cells and Immunoglobulin Class Switches Requires Costimulation by the Heat-stable Antigen

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Duration of TCR Stimulation Determines Costimulatory Requirement of T Cells

1996 • 372 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

Heat-stable antigen is a costimulatory molecule for CD4 T cell growth.

1992 • 254 citations

CD28 is required for germinal center formation.

1996 • 251 citations

Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP.

1995 • 178 citations

Distinct Costimulatory Molecules Are Required for the Induction of Effector and Memory Cytotoxic T Lymphocytes

1997 • 137 citations

Co‐stimulation of murine CD4 T cell growth: cooperation between B7 and heat‐stable antigen

1992 • 135 citations

Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.

1994 • 132 citations

Altered Erythrocytes and a Leaky Block in B-Cell Development in CD24/HSA-Deficient Mice

1997 • 128 citations

The Role of Somatic Mutation in the Generation of the Protective Humoral Immune Response against Vesicular Stomatitis Virus

1996 • 110 citations

Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.

1996 • 108 citations

CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.

1996 • 101 citations

B7/CD28-dependent and -independent induction of CD40 ligand expression.

1995 • 91 citations

Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors.

1996 • 82 citations

CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response.

1997 • 70 citations

Heat-stable antigen is an important costimulatory molecule on epidermal Langerhans' cells.

1994 • 55 citations

Induction of heat-stable antigen expression by phagocytosis is involved in in vitro activation of unprimed CTL by macrophages.

1996 • 52 citations

Antiviral immune responses in CTLA4 transgenic mice

1997 • 51 citations

Expression of heat-stable antigen on tumor cells provides co-stimulation for tumor-specific T cell proliferation and cytotoxicity in mice

1995 • 25 citations

Costimulatory signal provided by a B-lymphoblastoid cell line and its Ia-negative variant.

1989 • 17 citations

Signaling by a New Anti-Thy 1 Monoclonal Antibody Inhibits T Cell Proliferation and Interferes with T-Cell-Mediated Induction of Costimulatory Molecule B7-2

1995 • 8 citations

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