Inhibition of caspase activity induces a switch from apoptosis to necrosis

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Caspases: killer proteases

1997 • 2,440 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

1997 • 1,218 citations

Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)

1997 • 1,082 citations

An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide.

1985 • 1,068 citations

The molecular biology of apoptosis.

1996 • 963 citations

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

1997 • 663 citations

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death

1997 • 470 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

The molecular biology of apoptoseis.

1996 • 390 citations

Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway.

1997 • 376 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Nitric Oxide Synthase Induces Macrophage Death by Apoptosis

1993 • 361 citations

Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases

1997 • 316 citations

The Shape of Cell Death

1997 • 302 citations

Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4.

1993 • 214 citations

Caspase activity is required for commitment to Fas-mediated apoptosis

1997 • 132 citations

Ligation of major histocompatibility complex class II molecules mediates apoptotic cell death in resting B lymphocytes.

1993 • 116 citations

Fc receptor off-signal in the B cell involves apoptosis.

1996 • 106 citations

Requirement of the Caspase-3/CPP32 Protease Cascade for Apoptotic Death following Cytokine Deprivation in Hematopoietic Cells

1997 • 103 citations

An interleukin‐1β‐converting enzyme‐like protease is a common mediator of apoptosis in thymocytes

1995 • 101 citations

Involvement of CED-3/ICE Proteases in the Apoptosis of B-Chronic Lymphocytic Leukemia Cells

1997 • 92 citations

Specific Activation of the Cysteine Protease CPP32 during the Negative Selection of T Cells in the Thymus

1997 • 92 citations

Ligation of CD40 rescues Ramos‐Burkitt lymphoma B cells from calcium ionophore‐ and antigen receptor‐triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP

1996 • 70 citations

Involvement of caspases in sympathetic neuron apoptosis

1997 • 66 citations

The interleukin-1β converting enzyme family of cysteine proteases

1997 • 42 citations

Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal

1997 • 34 citations