Fractional exhaled nitric oxide in asthma: an update

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005

2005 • 2,932 citations

Anesthesiology

1997 • 2,182 citations

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial

2002 • 1,726 citations

Asthma

2001 • 1,547 citations

Increased nitric oxide in exhaled air of asthmatic patients

1994 • 1,462 citations

Allergy and Allergic Diseases

2001 • 1,349 citations

Increased amount of nitric oxide in exhaled air of asthmatics

1993 • 1,252 citations

Asthma: defining of the persistent adult phenotypes

2006 • 1,022 citations

Use of Exhaled Nitric Oxide Measurements to Guide Treatment in Chronic Asthma

2005 • 965 citations

Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements.

1996 • 964 citations

The biology of nitrogen oxides in the airways.

1994 • 928 citations

Eosinophils and Mast Cells in Bronchoalveolar Lavage in Subjects with Mild Asthma: Relationship to Bronchial Hyperreactivity

1988 • 905 citations

Nitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization

1993 • 825 citations

Bronchoscopic Evaluation of Severe Asthma

1997 • 775 citations

NO News Is Good News

1992 • 756 citations

Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide in Adults and Children—1999

1999 • 751 citations

Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.

1998 • 694 citations

Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force

1997 • 681 citations

Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma

1988 • 635 citations

Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients.

1996 • 588 citations

Airway Mucosal Inflammation Even in Patients with Newly Diagnosed Asthma

1993 • 543 citations

Late Asthmatic Responses

1987 • 538 citations

Differences in Airway Inflammation in Patients with Fixed Airflow Obstruction Due to Asthma or Chronic Obstructive Pulmonary Disease

2003 • 511 citations

Single-breath nitric oxide measurements in asthmatic patients and smokers

1994 • 498 citations

Diagnosing Asthma

2003 • 472 citations

Maximum Forced Expiratory Flow Rate as a Measure of Ventilatory Capacity

1959 • 463 citations

Relationship between Exhaled Nitric Oxide and Mucosal Eosinophilic Inflammation in Children with Difficult Asthma, after Treatment with Oral Prednisolone

2001 • 459 citations

Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial

2008 • 455 citations

Nitric oxide and lung disease.

1993 • 445 citations

Airway Inflammation Is Present during Clinical Remission of Atopic Asthma

2001 • 442 citations

The Predictive Value of Exhaled Nitric Oxide Measurements in Assessing Changes in Asthma Control

2001 • 441 citations

Identification of T lymphocytes, Macrophages, and Activated Eosinophils in the Bronchial Mucosa in Intrinsic Asthma: Relationship to Symptoms and Bronchial Responsiveness

1992 • 414 citations

Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections

1995 • 413 citations

Changes in Sputum Eosinophils Predict Loss of Asthma Control

2000 • 406 citations

Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years

2005 • 375 citations

Exhaled Nitric Oxide

2005 • 365 citations

Titrating Steroids on Exhaled Nitric Oxide in Children with Asthma

2005 • 360 citations

The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences

1999 • 354 citations

Expired nitric oxide levels during treatment of acute asthma.

1995 • 353 citations

The Use of Exhaled Nitric Oxide to Guide Asthma Management

2007 • 345 citations

Exhaled Nitric Oxide in Chronic Obstructive Pulmonary Disease

1998 • 324 citations

Predictive Markers of Asthma Exacerbation during Stepwise Dose Reduction of Inhaled Corticosteroids

2001 • 324 citations

Clinical Use of Noninvasive Measurements of Airway Inflammation in Steroid Reduction in Children

2005 • 322 citations

Height, Age, and Atopy Are Associated With Fraction of Exhaled Nitric Oxide in a Large Adult General Population Sample

2006 • 312 citations

The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma

2005 • 309 citations

Exhaled nitric oxide correlates with airway eosinophils in childhood asthma

2002 • 309 citations

Elevated levels of exhaled nitric oxide in bronchiectasis.

1995 • 308 citations

Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children

2003 • 308 citations

Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission

2005 • 298 citations

State of art: Late asthmatic responses

1987 • 294 citations

Identification of T-lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma

1992 • 279 citations

Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide.

1995 • 276 citations

Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma

1999 • 265 citations

NO in Exhaled Air of Asthmatic Children Is Reduced by the Leukotriene Receptor Antagonist Montelukast

1999 • 255 citations

Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath

2004 • 250 citations

Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients

1996 • 247 citations

Comparison of airway immunopathology of eosinophilic bronchitis and asthma

2003 • 240 citations

Corticosteroids decrease exhaled nitric oxide in children with acute asthma

1997 • 226 citations

Prospective Evaluation of the Validity of Exhaled Nitric Oxide for the Diagnosis of Asthmaa

2003 • 225 citations

Reference Ranges for Exhaled Nitric Oxide Derived from a Random Community Survey of Adults

2007 • 223 citations

A Community Study of Exhaled Nitric Oxide in Healthy Children

1999 • 220 citations

Daily Telemonitoring of Exhaled Nitric Oxide and Symptoms in the Treatment of Childhood Asthma

2008 • 219 citations

Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness

1999 • 212 citations

Airway Hyperresponsiveness, Inflammation, and Subepithelial Collagen Deposition in Recently Diagnosed versus Long-standing Mild Asthma

2000 • 208 citations

The arginine‐nitric oxide pathway: A target for new drugs

1994 • 206 citations

Adolescents in Clinical Remission of Atopic Asthma Have Elevated Exhaled Nitric Oxide Levels and Bronchial Hyperresponsiveness

2000 • 196 citations

Extended Exhaled NO Measurement Differentiates between Alveolar and Bronchial Inflammation

2001 • 191 citations

Performance of a new hand-held device for exhaled nitric oxide measurement in adults and children

2006 • 190 citations

A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation

2000 • 188 citations

Fraction of Exhaled Nitric Oxide at 50 mL/s

2007 • 188 citations

Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids

2005 • 186 citations

Influence of atopy on exhaled nitric oxide in patients with stable asthma and rhinitis

1999 • 181 citations

Dose-Response Relationship and Reproducibility of the Fall in Exhaled Nitric Oxide After Inhaled Beclomethasone Dipropionate Therapy in Asthma Patients

2001 • 181 citations

Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults

2009 • 180 citations

Portable Exhaled Nitric Oxide Measurement

2007 • 174 citations

Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible NO synthase upregulation in alveolar macrophages

1998 • 171 citations

Management of chronic cough

2008 • 167 citations

Sputum analysis, bronchial hyperresponsiveness, and airway function in asthma: Results of a factor analysis

1999 • 166 citations

Exhaled Nitric Oxide as a Noninvasive Assessment of Chronic Cough

1999 • 163 citations

The Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the US Food and Drug Administration for monitoring therapy in asthma

2004 • 158 citations

Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide

1998 • 158 citations

Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase.

1996 • 158 citations

Exhaled Nitric Oxide after β₂-agonist Inhalation and Spirometry in Asthma

1999 • 156 citations

Exhaled Nitric Oxide as a Diagnostic Test for Asthma

2002 • 155 citations

Airway Eosinophilia in Children with Severe Asthma

2006 • 154 citations

Measurement of Bronchial and Alveolar Nitric Oxide Production in Normal Children and Children with Asthma

2006 • 153 citations

Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids

1998 • 152 citations

Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment

2001 • 151 citations

Reference values for exhaled nitric oxide (reveno) study

2006 • 149 citations

Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients

2007 • 148 citations

Expired Nitric Oxide after Bronchoprovocation and Repeated Spirometry in Patients with Asthma

1998 • 139 citations

Increased nitric oxide in exhaled air after intake of a nitrate-rich meal

2001 • 136 citations

Exhaled nitric oxide and biomarkers in exhaled breath condensate indicate the presence, severity and control of childhood asthma

2007 • 135 citations

Relationship between Exhaled Nitric Oxide and Childhood Asthma

1998 • 135 citations

Decreased Exhaled Nitric Oxide in Pulmonary Arterial Hypertension

2005 • 134 citations

Exhaled nitric oxide in the management of childhood asthma: A prospective 6‐months study

2006 • 133 citations

Grass pollen immunotherapy as an effective therapy for childhood seasonal allergic asthma

2006 • 131 citations

Decreased nitric oxide in the exhaled air of patients with systemic sclerosis with pulmonary hypertension

1997 • 128 citations

Exhaled Nitric Oxide (NO) Is Reduced Shortly after Bronchoconstriction to Direct and Indirect Stimuli in Asthma

1998 • 128 citations

Exhaled Nitric Oxide in Patients with Asthma

2000 • 120 citations

Exhaled nitric oxide predicts lung function decline in difficult-to-treat asthma

2008 • 119 citations

Exhaled Nitric Oxide and Exercise-Induced Bronchoconstriction in Asthmatic Children

2000 • 116 citations

Using fractional exhaled nitric oxide to guide asthma therapy: design and methodological issues for ASthma TReatment ALgorithm studies

2009 • 114 citations

Sex differences in concentrations of exhaled nitric oxide and plasma nitrate

1996 • 113 citations

Exhaled Nitric Oxide: The Effects of Age, Gender and Body Size

2001 • 112 citations

Factors affecting exhaled nitric oxide measurements: the effect of sex

2007 • 104 citations

Exhaled Nitric Oxide Predicts Asthma Exacerbation

2004 • 102 citations

Exhaled nitric oxide in asthma: From bench to bedside

2003 • 102 citations

Exhaled Nitric Oxide in Human Lung Transplantation

1998 • 101 citations

Exhaled Nitric Oxide and Bronchial Reactivity During and After Inhaled Beclomethasone in Mild Asthma

1998 • 101 citations

Effect of short- and long-acting inhaled beta2-agonists on exhaled nitric oxide in asthmatic patients

1997 • 99 citations

Exhaled nitric oxide and its relationship to airway responsiveness and atopy in asthma

1999 • 99 citations

Orally exhaled nitric oxide levels are related to the degree of blood eosinophilia in atopic children with mild-intermittent asthma

1999 • 99 citations

Passive Smoke Inhalation Decreases Exhaled Nitric Oxide in Normal Subjects

2001 • 97 citations

Post–lung Transplant Bronchiolitis Obliterans Syndrome (BOS) Is Characterized by Increased Exhaled Nitric Oxide Levels and Epithelial Inducible Nitric Oxide Synthase

2000 • 93 citations

Reliability of a new hand‐held device for the measurement of exhaled nitric oxide

2007 • 90 citations

Effect of Montelukast on Exhaled Nitric Oxide and Nonvolatile Markers of Inflammation in Mild Asthma

2003 • 90 citations

Daily home measurements of exhaled nitric oxide in asthmatic children during natural birch pollen exposure

2006 • 89 citations

Exhaled monoxides in asymptomatic atopic subjects

1999 • 89 citations

Variants of NOS1, NOS2, and NOS3 Genes in Asthmatics

2000 • 88 citations

Atopy Influences Exhaled Nitric Oxide Levels in Adult Asthmatics

2000 • 88 citations

Exhaled nitric oxide during exercise: site of release and modulation by ventilation and blood flow

1996 • 85 citations

Exhaled Nitric Oxide in Children With Asthma Receiving Xolair (Omalizumab), a Monoclonal Anti-Immunoglobulin E Antibody

2004 • 85 citations

Exhaled nitric oxide as a marker of airway inflammation for an epidemiologic study in schoolchildren

2004 • 85 citations

Exhaled nitric oxide in chronic obstructive pulmonary disease: relationship to pulmonary function

2001 • 83 citations

High levels and gender difference of exhaled nitric oxide in Chinese schoolchildren

2005 • 82 citations

Short and long-term effects of cigarette smoking independently influence exhaled nitric oxide concentration in asthma

2005 • 81 citations

Differential Flow Analysis of Exhaled Nitric Oxide in Patients With Asthma of Differing Severity

2007 • 79 citations

Elevated Exhaled Nitric Oxide in Newborns of Atopic Mothers Precedes Respiratory Symptoms

2006 • 78 citations

Increased levels of nitric oxide derivatives in induced sputum in patients with asthma

1997 • 76 citations

Endogenous vasoactive intestinal peptide and nitric oxide modulate cholinergic neurotransmission in guinea-pig trachea

1993 • 76 citations

Exhaled Nitric Oxide During Exercise in Primary Pulmonary Hypertension and Pulmonary Fibrosis

1997 • 75 citations

Asthma, inflammation, eosinophils and bronchial hyperresponsiveness

1992 • 72 citations

Effects of Corticosteroids on Noninvasive Biomarkers of Inflammation in Asthma and Chronic Obstructive Pulmonary Disease

2004 • 72 citations

A comparison of exhaled nitric oxide measurements performed using three different analysers

2006 • 70 citations

The effect of alcohol ingestion on exhaled nitric oxide

1996 • 67 citations

Airway Inflammation in Premenstrual Asthma

2002 • 66 citations

Genetic analysis of nitric oxide and endothelin in end‐stage renal disease

2000 • 63 citations

Nitric Oxide and Exhaled Breath Nitrite/Nitrates in Chronic Obstructive Pulmonary Disease Patients

2007 • 63 citations

Is exhaled nitric oxide measurement a useful clinical test in asthma?

2005 • 61 citations

Nitric oxide regulation of asthmatic airway inflammation with segmental allergen challenge☆☆☆

1999 • 58 citations

Effect of nasal triamcinolone acetonide on lower airway inflammatory markers in patients with allergic rhinitis

2003 • 58 citations

Exhaled and nasal nitric oxide is increased in laboratory animal allergy

1998 • 58 citations

Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels

2006 • 55 citations

F<scp>e</scp> _NO: Relationship to Exhalation Rates and Online versus Bag Collection in Healthy Adolescents

2000 • 55 citations

Exhaled nitric oxide as a marker in asthma.

1998 • 54 citations

Lung function changes in relation to menstrual cycle in females with cystic fibrosis

2000 • 53 citations

The relationship between exhaled nitric oxide and allergic sensitization in a random sample of school children

2003 • 51 citations

Increased production of endogenous nitric oxide in patients with bronchial asthma and chronic obstructive pulmonary disease

1998 • 49 citations

Short-term variability of exhaled nitric oxide in young male patients with mild asthma and in healthy subjects

2002 • 47 citations

Early rise in exhaled nitric oxide and mast cell activation in repeated low-dose allergen challenge

2006 • 44 citations

Reduction in exhaled nitric oxide immediately after methacholine challenge in asthmatic children

2002 • 40 citations

Exhaled Nitric Oxide Daily Evaluation Is Effective in Monitoring Exposure to Relevant Allergens in Asthmatic Children

2007 • 38 citations

Safety of sputum induction with isotonic saline in adults with acute severe asthma

2001 • 38 citations

Effect of β₂‐agonist treatment and spirometry on exhaled nitric oxide in healthy children and children with asthma

2002 • 37 citations

The effect of the menstrual cycle on exhaled nitric oxide and urinary nitrate concentration

1996 • 33 citations

Exhaled Nitric Oxide and Bronchoalveolar Lavage Nitrite/Nitrate in Active Pulmonary Sarcoidosis

1997 • 32 citations

Comparison of exhaled nitric oxide analysers

2004 • 32 citations

Biomarkers in the assessment and management of airways diseases

2008 • 31 citations

Serial Exhaled Nitric Oxide Measurements in the Assessment of Laboratory Animal Allergy

2008 • 29 citations

Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy

2006 • 29 citations

Dissecting innate immune responses with the tools of systems biology

2004 • 29 citations

Increased nitric oxide in expired air in patients with Sjögren′s syndrome

1999 • 27 citations

Effect of ecNOS polymorphisms and coronary artery disease upon exhaled nitric oxide

2001 • 26 citations

Role of Endogenous Nitric Oxide in Airflow Obstruction in Smokers

1996 • 24 citations

Severe asthma in adults.

2005 • 20 citations

Changes in exhaled nitric oxide levels with immunotherapy.

2006 • 8 citations

AMP challenge induces a decrease in FE_NO in asthmatic subjects modulated by nedocromil

2006 • 3 citations