Involvement of Bcl-2 Cleavage in the Acceleration of VP-16-Induced U937 Cell Apoptosis

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Caspases and caspase inhibitors

1997 • 573 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Actin cleavage by CPP-32/apopain during the development of apoptosis

1997 • 251 citations

Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation

1995 • 210 citations

Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2

1998 • 189 citations

Aspartate-Based Inhibitor of Interleukin-1β-Converting Enzyme Prevents Antitumor Agent-Induced Apoptosis in Human Myeloid Leukemia U937 Cells

1995 • 151 citations

The gene family

1995 • 130 citations

Interleukin-7 inhibits apoptosis of mouse malignant T-lymphoma cells by both suppressing the CPP32-like protease activation and inducing the Bcl-2 expression.

1996 • 27 citations

Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell surface adhesion molecules.

1993 • 26 citations

Aggregation of Thy-1 Glycoprotein Induces Thymocyte Apoptosis through Activation of CPP32-like Proteases

1997 • 17 citations

Induction of in vitro nuclear apoptosis activity coincides with the production of 50 kDa cytosolic protein

1997 • 4 citations