Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

1973 • 2,275 citations

Handbook of experimental pharmacology

1984 • 1,599 citations

Blood Levels of Organochlorine Residues and Risk of Breast Cancer

1993 • 849 citations

Comparative Study of Human and Rat Mammary Tumorigenesis

1990 • 585 citations

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

Quantitation of mutagegnic/carcinogenic heterocyclic aromatic amines in food products

1992 • 396 citations

Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process

1985 • 373 citations

Mutagenicities of smoke condensates and the charred surface of fish and meat

1977 • 354 citations

Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

1991 • 340 citations

Carcinogenicities of heterocyclic amines in cooked food

1991 • 318 citations

Dietary inhibitors of mutagenesis and carcinogenesis

1988 • 314 citations

Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.

1990 • 291 citations

The isolation and identification of a new mutagen from fried ground beef: 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP)

1986 • 283 citations

Mutagenic Principle(s) in Tryptophan and Phenylalanine Pyrolysis Products

1977 • 282 citations

Formation of Mutagens in Beef and Beef Extract During Cooking

1978 • 264 citations

Occurrence, identification, and bacterial mutagenicity of heterocyclic amines in cooked food

1991 • 258 citations

Identification of the mutagens in cooked beef.

1986 • 244 citations

Mutagens, carcinogens, and tumor promoters in our daily food

1982 • 233 citations

Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques

1990 • 224 citations

Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation

1991 • 184 citations

Isolation and characterization of new mutagens from fried ground beef

1984 • 180 citations

Simple methods for quantifying mutagenic heterocyclic aromatic amines in food products

1990 • 176 citations

Potent novel mutagens produced by broiling fish under normal conditions.

1980 • 154 citations

Mutagenicity of amino-α-carbolines in pyrolysis products of soybean globulin

1978 • 154 citations

Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates.

1987 • 148 citations

STRUCTURE OF A POTENT MUTAGEN ISOLATED FROM FRIED BEEF

1981 • 146 citations

Isolation and structure determination of mutagenic substances in L-glutamic acid pyrolysate.

1978 • 139 citations

Anti-mutagenic action of vegetable factor(s) on the mutagenic principle of tryptophan pyrolysate

1978 • 134 citations

Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef.

1992 • 121 citations

Inhibitory effect of chlorophyll on the genotoxicity of 3-amino-1-methyl-5H-pyrido[4,3-b indole (Trp-P-2)

1989 • 119 citations

The Contributions of Diet and Childbearing to Breast-cancer Rates

1978 • 118 citations

Inhibition of the mutagenicity of amino acid pyrolysis products by hemin and other biological pyrrole pigments

1980 • 118 citations

Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B₁ (AFB₁)-DNA binding in vivo and anti-mutagenic activity against AFB₁ and two heterocyclic amines in the salmonella mutagenicity assay

1991 • 110 citations

Dietary fiber and breast cancer

1990 • 103 citations

Multipotential carcinogenicity of the fried food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in rats.

1985 • 102 citations

Influence of creatine, amino acids and water on the formation of the mutagenic heterocyclic amines found in cooked meat

1989 • 96 citations

Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal

1989 • 94 citations

Mammalian cell mutagenicity and metabolism of heterocyclic aromatic amines

1991 • 90 citations

Effects of plant-derived flavonoids and polyphenolic acids on the activity of mutagens from cooked food

1986 • 86 citations

Isolation and identification of mutagens from a fried Norwegian meat product

1988 • 84 citations

Mutagens from the cooking of food. II. Survey by Ames/Salmonella test of mutagen formation in the major protein-rich foods of the American diet

1982 • 81 citations

Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]qiiinoline (IQ) to rat liver DNA

1992 • 73 citations

³²P-Postlabeling analysis of IQ, MelQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MelQx- and PhIP-treated monkeys

1993 • 72 citations

Enzymatic phase II activation of the N-hydroxylamines of IQ, MelQx and PhIP by various organs of monkeys and rats

1993 • 67 citations

Adsorption of pyrolysate mutagens by vegetable fibers

1984 • 63 citations

Induction of tumors in the Zymbal gland, oral cavity, colon, skin and mammary gland of F344 rats by a mutagenic compound, 2-amino_-3, 4-dimethylimidazo[4, 5-f)quinoline

1989 • 62 citations

Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses

1991 • 59 citations

Antimutagenicity of ellagic acid towards the food mutagen IQ: Investigation into possible mechanisms of action

1992 • 58 citations

In Vitro Binding of the Food Mutagen 2-Amino-3-methylimidazo[4,5-<italic>f</italic>]quinoline to Dietary Fibers<xref ref-type="fn" rid="fn2">2</xref>

1983 • 53 citations

Mutagenicity of human urine caused by ingestion of fried ground beef.

1985 • 49 citations

Mutagenic activation of IQ, PhIP, and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo

1993 • 48 citations

Inhibition of protein pyrolysate mutagenicity by retinol (Vitamin A)

1982 • 43 citations

N-Hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver

1992 • 43 citations

Inhibition of the mutagenicity of cooked-beef basic fraction by its acidic fraction

1981 • 40 citations

Metabolic processing and carcinogenicity of heterocyclic amines in nonhuman primates.

1990 • 39 citations

A solvent effect on the mutagenicity of tryptophan-pyrolysate mutagens in the Salmonella/mammalian microsome assay

1982 • 36 citations

High mutagenic activity formed in pan-broiled pork

1984 • 34 citations

Inhibition of 2-amino-3-methylimidazo[4,5-ƒ]quinoline-DNA adduct formation in CDF1 mice by heat-altered derivatives of linoleic acid

1992 • 33 citations

Binding of ¹⁴C‐Labeled Food Mutagens (IQ, MeIQ, MeIQx) by Dietary Fiber In Vitro

1985 • 32 citations

Loss of heterocyclic amine mutagens by insoluble hemicellulose fiber and high-molecular-weight soluble polyphenolics of coffee

1991 • 31 citations

Effect of cooking time on mutagen formation in smoke, crust and pan residue from pan-broiled pork

1990 • 30 citations

Proposed Structures for an an amino-dimethylimidazofuropyridine mutagen in cooked meats

1990 • 30 citations

Adsorption of mutagens by refined corn bran

1988 • 29 citations

Metabolic activation of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) to DNA binding species in human mammary epithelial cells

1992 • 27 citations

Reversible binding of the cooked food mutagen MeIQx to lignin-enriched preparations from wheat bran

1992 • 27 citations

Use of blue cotton for detection of mutagenicity in human feces excreted after ingestion of cooked meat.

1986 • 25 citations

Influence of fried meat and fiber on cytochrome P-450 mediated activity and excretion of mutagens in rats

1988 • 24 citations

Detection of 2‐Amino‐1‐methyl‐6‐(4‐hydroxyphenyl)imidazo[4,5‐b]pyridine in Broiled Beef

1992 • 24 citations

Metabolism of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates undergoing carcinogen bioassay

1992 • 23 citations

Effect of 3-methylcholanthrene induction on the distribution and DNA adduction of 2-amino-3-methylimidazo[4,5-ƒ]quinoline (IQ) in F344 rats

1993 • 18 citations

A Convenient Synthesis of the Potent Mutagen 3,4,8-Trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine.

1985 • 17 citations

Anthraflavic acid inhibits the mutagenicity of the food mutagen IQ: Mechanism of action

1988 • 16 citations

Ingestion of parsley inhibits the mutagenicity of male human urine following consumption of fried salmon

1987 • 14 citations

Heterocyclic amines in cooked foods : possible human carcinogens : proceedings of the 23rd International Symposium of the Princess Takamatsu Cancer Research Fund

1995 • 12 citations

Enhancement of hepatocellular genotoxicity of several mutagens from amino acid pyrolysates and broiled foods following ethanol pretreatment

1985 • 11 citations

Effect of dietary fat levels on the susceptibility of colonic cells to nuclear‐damaging agents

1986 • 11 citations

Effect in vitro of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on the hepatic activation of dietary genotoxins by rat post-mitochondrial fractions

1992 • 4 citations