Apoptosis Generates Stable Fragments of Human Type I Keratins

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells

1982 • 5,272 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Intermediate filaments as mechanical integrators of cellular space

1980 • 1,973 citations

INTERMEDIATE FILAMENTS: Structure, Dynamics, Function and Disease

1994 • 1,408 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

A License to Kill

1996 • 649 citations

Caspase Cleavage of Keratin 18 and Reorganization of Intermediate Filaments during Epithelial Cell Apoptosis

1997 • 596 citations

Lamin proteolysis facilitates nuclear events during apoptosis.

1996 • 587 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns.

1990 • 375 citations

The cell-death machine

1996 • 351 citations

Intermediate filaments in disease

1995 • 248 citations

Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy

1997 • 247 citations

Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest it Evolved from Keratinocyte Keratins.

1989 • 238 citations

14-3-3 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor.

1996 • 209 citations

The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas

1993 • 195 citations

Dynamic property of intermediate filaments: Regulation by phosphorylation

1996 • 183 citations

THE CYTOSKELETON AND DISEASE: Genetic Disorders of Intermediate Filaments

1996 • 177 citations

Remarkable conservation of structure among intermediate filament genes

1984 • 169 citations

Death substrates come alive

1997 • 167 citations

Keratin 19: Predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins

1989 • 155 citations

The polypeptide composition of bovine epidermal α-keratin

1975 • 153 citations

Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments

1997 • 146 citations

Tissue polypeptide antigen (TPA) is related to the non-epidermal keratins 8, 18 and 19 typical of simple and non-squamous epithelia: re-evaluation of a human tumor marker.

1984 • 145 citations

Of mice and men: Genetic skin diseases of keratin

1992 • 135 citations

Stress, Apoptosis, and Mitosis Induce Phosphorylation of Human Keratin 8 at Ser-73 in Tissues and Cultured Cells

1997 • 122 citations

The adenovirus L3 23-kilodalton proteinase cleaves the amino-terminal head domain from cytokeratin 18 and disrupts the cytokeratin network of HeLa cells

1993 • 120 citations

The cellular and molecular biology of keratins: beginning a new era

1993 • 107 citations

Implications of intermediate filament protein phosphorylation

1996 • 106 citations

Phosphorylation of Human Keratin 8 in Vivo at Conserved Head Domain Serine 23 and at Epidermal Growth Factor-stimulated Tail Domain Serine 431

1997 • 103 citations

Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.

1994 • 94 citations

Missing links: Weber–Cockayne keratin mutations implicate the L12 linker domain in effective cytoskeleton function

1993 • 94 citations

Cytokeratin phosphorylation, cytokeratin filament severing and the solubilization of the maternal mRNA Vg1.

1991 • 92 citations

Intermediate filament proteins of the liver: Emerging disease association and functions

1997 • 89 citations

Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues.

1995 • 80 citations

Differential localization by in situ hybridization of distinct keratin mRNA species during intestinal epithelial cell development and differentiation

1993 • 69 citations

A mutation (met→arg) in the type I keratin (K14) gene responsible for autosomal dominant epidermolysis bullosa simplex

1993 • 62 citations

Phosphorylation-Dependent Control of Structures of Intermediate Filaments: A Novel Approach Using Site- and Phosphorylation State-Specific Antibodies

1997 • 59 citations

Identification and Mutational Analysis of the Glycosylation Sites of Human Keratin 18

1995 • 58 citations

Genetic skin diseases caused by mutations in keratin intermediate filaments

1993 • 56 citations

Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin.

1988 • 49 citations

Evidence for coordinated phosphorylation of keratins and vimentin during mitosis in transformed human amnion cells

1983 • 38 citations

Epitope Mapping of Monoclonal Antibodies to Keratin 19 Using Keratin Fragments, Synthetic Peptides and Phage Peptide Libraries

1995 • 31 citations

Epitope Mapping of Monoclonal Antibodies to Keratin 19 Using Keratin Fragments, Synthetic Peptides and Phage Peptide Libraries

1995 • 28 citations

Intracellular localization of types i and ii collagen mrna and endoplasmic reticulum in embryonic corneal epithelia

1991 • 26 citations

Significance of cytokeratin markers TPA, TPA (cyk), TPS and CYFRA 21.1 in metastatic disease.

1996 • 24 citations