Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Chapter 4 Preparation of Isolated Rat Liver Cells

1976 • 5,335 citations

The Toxins of Cyanobacteria

1994 • 1,101 citations

Phosphorylation of the nuclear lamins during interphase and mitosis.

1985 • 354 citations

Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases

1990 • 340 citations

Tumor Promotion by Inhibitors of ProteinZ Phosphatases 1 and 2A: The Okadaic Acid Class of Compounds

1993 • 310 citations

Desmosomes and hemidesmosomes

1993 • 310 citations

The cyanobacterial toxin microcystin binds covalently to cysteine‐273 on protein phosphatase 1

1995 • 284 citations

Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.

1994 • 283 citations

Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase.

1988 • 279 citations

Cell Adhesion Molecules as Targets of Autoantibodies in Pemphigus and Pemphigoid, Bullous Diseases Due to Defective Epidermal Cell Adhesion

1993 • 262 citations

Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins

1992 • 227 citations

Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin

1990 • 224 citations

The relationship between intermediate filaments and microfilaments before and during the formation of desmosomes and adherens-type junctions in mouse epidermal keratinocytes.

1987 • 183 citations

Liver Pathology in Mice in Poisoning by the Blue-Green Alga Microcystis Aeruginosa

1981 • 176 citations

Cytoskeletal integrity in interphase cells requires protein phosphatase activity.

1992 • 174 citations

Antibodies to epithelial desmosomes show wide tissue and species cross-reactivity

1983 • 160 citations

Toxicity of Microcystin LR, a Cyclic Heptapeptide Hepatotoxin fromMicrocystis aeruginosa,to Rats and Mice

1989 • 159 citations

Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxin

1989 • 152 citations

Intermediate filament dynamics

1992 • 143 citations

The uptake of the cyanobacterial hepatotoxin microcystin by isolated rat hepatocytes

1991 • 141 citations

Assembly-disassembly of the nuclear lamina

1992 • 136 citations

Alterations in Microtubules, Intermediate Filaments, and Microfilaments Induced by Microcystin-LR in Cultured Cells

1995 • 128 citations

Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks.

1994 • 124 citations

Cytokeratins and the liver

1993 • 122 citations

Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes

1992 • 121 citations

Making heads and tails of intermediate filament assembly, dynamics and networks

1994 • 120 citations

Antidesmosomal monoclonal antibody in the diagnosis of intracranial tumours

1987 • 119 citations

Protein phosphatase type-1, not type-2A, modulates actin microfilament integrity and myosin light chain phosphorylation in living nonmuscle cells.

1990 • 118 citations

Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

1988 • 96 citations

Identification of protein phosphatase 2A as the primary target for microcystin‐LR in rat liver homogenates

1994 • 96 citations

Rapid analysis of peptide toxins in cyanobacteria

1988 • 95 citations

Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.

1994 • 94 citations

IFAP 300 is common to desmosomes and hemidesmosomes and is a possible linker of intermediate filaments to these junctions.

1994 • 92 citations

Effect of toxin from the cyanobacterium Microcystis aeruginosa on ultrastructural morphology and actin polymerization in isolated hepatocytes

1986 • 91 citations

Comparison of in vivo and in vitro toxic effects of microcystin-LR in fasted rats

1989 • 90 citations

Localisation of the protein and glycoprotein components of bovine nasal epithelial desmosomes by immunoelectron microscopy.

1987 • 87 citations

Phosphorylation of keratin intermediate filaments by protein kinase C, by calmodulin‐dependent protein kinase and by cAMP‐dependent protein kinase

1991 • 84 citations

Synthesis, organotropism and hepatocellular uptake of two tritium-labeled epimers of dihydromicrocystin-LR, a cyanobacterial peptide toxin analog

1990 • 83 citations

Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues.

1995 • 80 citations

Phosphorylation and disruption of intermediate filament proteins in oligodendrocyte precursor cultures treated with calyculin A

1993 • 79 citations

Protein phosphatase inhibitors okadaic acid and calyculin A alter cell shape and F-actin distribution and inhibit stimulus-dependent increases in cytoskeletal actin of human neutrophils

1992 • 69 citations

Inhibitors of protein phosphatase-1 and -2A; two of the major serine/threonine protein phosphatases involved in cellular regulation

1993 • 64 citations

Desmosome assembly and disassembly are regulated by reversible protein phosphorylation in cultured epithelial cells

1995 • 64 citations

Relationship between intermediate filaments and microfilaments in cultured fibroblasts: Evidence for common foci during cell spreading

1986 • 60 citations

Reversible hyperphosphorylation and reorganization of vimentin intermediate filaments by okadaic acid in 9L rat brain tumor cells

1992 • 59 citations

Cytoskeletal reorganization of human platelets induced by the protein phosphatase 1/2 A inhibitors okadaic acid and calyculin A

1995 • 57 citations

Evidence that intermediate filament reorganization is induced by ATP-dependent contraction of the actomyosin cortex in permeabilized fibroblasts

1991 • 55 citations

Okadaic acid induces the rapid and reversible disruption of the neurofilament network in rat dorsal root ganglion neurons

1992 • 50 citations

Identification of Phosphorylation Sites on Glial Fibrillary Acidic Protein for cdc2 Kinase and Ca2+-Calmodulin-Dependent Protein Kinase II1

1994 • 47 citations

Phosphopeptide Mapping and Phosphoamino Acid Analysis on Cellulose Thin-Layer Plates

1994 • 45 citations

Hyperphosphorylation of keratins by treatment with okadaic acid of BALB/MK-2 mouse keratinocytes.

1993 • 40 citations

Changes in the cytoskeleton of 3T3 fibroblasts induced by the phosphatase inhibitor, calyculin-A

1992 • 39 citations

Changes in the cytoskeletal structure of cultured smooth muscle cells induced by calyculin-A

1993 • 37 citations

Regulation of cytoskeletal organization in tumor cells by protein phosphatases‐1 and ‐2A

1995 • 32 citations

Increased phosphorylation of the amino-terminal domain of the low molecular weight neurofilament subunit in okadaic acid-treated neurons

1994 • 32 citations

Okadaic acid‐induced actin assembly in neutrophils: Role of protein phosphatases

1993 • 30 citations

Distribution of desmoplakin in normal cultured human keratinocytes and in basal cell carcinoma cells

1989 • 23 citations

Site‐specific antibodies block kinase a phosphorylation of desmin in vitro and inhibit incorporation of myoblasts into myotubes

1991 • 23 citations

Keratin 8 Phosphorylationin Vitroby cAMP-Dependent Protein Kinase Occurs within the Amino- and Carboxyl-Terminal End Domains

1996 • 23 citations

Role of phosphorylation in keratin and vimentin filament integrity in cultured thyroid epithelial cells

1993 • 13 citations

Morphological Changes and Reorganization of Actinfilaments in Human Myeloid Leukemia Cells Induced by a Novel Protein Phosphatase Inhibitor, Tautomycin.

1993 • 7 citations