Dynamic property of intermediate filaments: Regulation by phosphorylation

Intermediate filaments as mechanical integrators of cellular space

1980 • 1,973 citations

INTERMEDIATE FILAMENTS: Structure, Dynamics, Function and Disease

1994 • 1,408 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

1983 • 1,162 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells

1992 • 741 citations

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

1990 • 642 citations

Site-specific phosphorylation induces disassembly of vimentin filaments in vitro

1987 • 442 citations

Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C

1990 • 425 citations

Identification of the major multiphosphorylation site in mammalian neurofilaments.

1988 • 394 citations

Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin

1990 • 328 citations

Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber.

1994 • 278 citations

Intermediate filament proteins in nonfilamentous structures: Transient disintegration and inclusion of subunit proteins in granular aggregates

1982 • 250 citations

Phosphorylation of desmin in vitro inhibits formation of intermediate filaments; identification of three kinase A sites in the aminoterminal head domain.

1988 • 224 citations

Intermediate filament reconstitution in vitro. The role of phosphorylation on the assembly-disassembly of desmin.

1988 • 205 citations

Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase.

1991 • 188 citations

Neuronal cdc2-like kinase

1995 • 179 citations

Cytoskeletal integrity in interphase cells requires protein phosphatase activity.

1992 • 174 citations

Phosphorylation and disassembly of intermediate filaments in mitotic cells.

1989 • 167 citations

Identification of a nonapeptide motif in the vimentin head domain involved in intermediate filament assembly

1992 • 164 citations

An alteration in the phosphorylation of vimentin-type intermediate filaments is associated with mitosis in cultured mammalian cells

1982 • 158 citations

Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure

1989 • 158 citations

Glial Fibrillary Acidic Protein: Dynamic Property and Regulation by Phosphorylation

1994 • 156 citations

Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain.

1990 • 155 citations

Intermediate filament dynamics

1992 • 143 citations

Phosphorylation of keratin and vimentin polypeptides in normal and transformed mitotic human epithelial amnion cells: behavior of keratin and vimentin filaments during mitosis.

1983 • 141 citations

Phosphorylation of neurofilament H subunit at the tail domain by CDC2 kinase dissociates the association to microtubules.

1991 • 140 citations

Visualization and function of vimentin phosphorylation by cdc2 kinase during mitosis.

1994 • 140 citations

Identification of protein kinase C (PKC) phosphorylation sites on human lamin B. Potential role of PKC in nuclear lamina structural dynamics.

1993 • 139 citations

Assembly-disassembly of the nuclear lamina

1992 • 136 citations

Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios

1991 • 134 citations

Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase.

1989 • 134 citations

A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro.

1991 • 133 citations

Phosphorylation of the amino-terminal head domain of the middle molecular mass 145-kDa subunit of neurofilaments. Evidence for regulation by second messenger-dependent protein kinases.

1990 • 126 citations

Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2.

1993 • 120 citations

Mitotic arrest-associated enhancement of O-linked glycosylation and phosphorylation of human keratins 8 and 18.

1993 • 119 citations

Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. Early turnover during axonal transport.

1991 • 119 citations

Vimentin is transiently co-localized with and phosphorylated by cyclic GMP-dependent protein kinase in formyl-peptide-stimulated neutrophils.

1991 • 118 citations

Mitogen‐activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34^cdc2

1992 • 104 citations

The regulation of intermediate filament reorganization in mitosis.

1991 • 103 citations

Two different protein kinases act on a different time schedule as glial filament kinases during mitosis.

1992 • 102 citations

Specific localization of phosphointermediate filament protein in the constricted area of dividing cells.

1991 • 101 citations

Phosphorylation in vitro of vimentin by protein kinases A and C is restricted to the head domain

1989 • 99 citations

Spatiotemporal distribution of protein kinase and phosphatase activities

1994 • 93 citations

Cytokeratin phosphorylation, cytokeratin filament severing and the solubilization of the maternal mRNA Vg1.

1991 • 92 citations

Assembly of amino-terminally deleted desmin in vimentin-free cells.

1990 • 91 citations

Cyclic AMP‐dependent protein kinase‐induced vimentin filament disassembly involves modification of the N‐terminal domain of intermediate filament subunits

1988 • 86 citations

Phosphorylation of bovine neurofilament proteins by protein kinase FA (glycogen synthase kinase 3)

1991 • 86 citations

Phosphorylation of keratin intermediate filaments by protein kinase C, by calmodulin‐dependent protein kinase and by cAMP‐dependent protein kinase

1991 • 84 citations

Involvement of protein kinase C in the regulation of assembly-disassembly of neurofilaments in vitro

1990 • 81 citations

Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues.

1995 • 80 citations

Protein Kinase C Phosphorylation of Desmin at Four Serine Residues within the Non-α-Helical Head Domain

1989 • 75 citations

Mitosis-specific phosphorylation of vimentin by protein kinase C coupled with reorganization of intracellular membranes.

1996 • 74 citations

Effect of phosphorylation on 68 KDa neurofilament subunit protein assembly by the cyclic AMP dependent protein kinase in vitro

1990 • 73 citations

Differential targeting of protein kinase C and CaM kinase II signalings to vimentin.

1995 • 70 citations

p13suc1 suppresses the catalytic function of p34cdc2 kinase for intermediate filament proteins, in vitro.

1992 • 70 citations

Axotomy-induced neurofilament phosphorylation is inhibited in situ by micromjection of PKA and PKC inhibitors into identified lamprey neurons

1993 • 68 citations

Evidence that Ser-82 is a unique phosphorylation site on vimentin for CA2+-calmodulin-dependent protein kinase II

1991 • 64 citations

Activation of Ca2+/calmodulin-dependent protein kinase II and phosphorylation of intermediate filament proteins by stimulation of glutamate receptors in cultured rat cortical astrocytes.

1994 • 62 citations

Phosphorylation of neurofilament proteins by endogenous calcium/calmodulin-dependent protein kinase

1985 • 55 citations

Identification of novel phosphorylation sites in murine A‐type lamins

1993 • 52 citations

Neuronal intermediate filaments: new progress on an an old subject

1994 • 51 citations

Identification of Phosphorylation Sites on Glial Fibrillary Acidic Protein for cdc2 Kinase and Ca2+-Calmodulin-Dependent Protein Kinase II1

1994 • 47 citations

Detection of protein kinase activity specifically activated at metaphase-anaphase transition.

1996 • 45 citations

Ca2+-Calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins

1990 • 41 citations

Hyperphosphorylation of keratins by treatment with okadaic acid of BALB/MK-2 mouse keratinocytes.

1993 • 40 citations

Identification and characterization of a novel (115 kDa) neurofilament- associated kinase

1994 • 33 citations

Proline‐Directed Protein Kinase (p34^cdc2/p58^{cyclin A}) Phosphorylates Bovine Neurofilaments

1992 • 31 citations

Bovine neurofilament-enriched preparations contain kinase activity similar to casein kinase I — Neurofilament phosphorylation by casein kinase I (CKI)

1993 • 31 citations

cdc2 Kinase Phosphorylation of Desmin at Three Serine/Threonine Residues in the Amino-Terminal Head Domain

1993 • 30 citations

Assembly regulatory domain of glial fibrillary acidic protein. A single phosphorylation diminishes its assembly-accelerating property

1992 • 27 citations

Visualization of protein kinase activities in single cells by antibodies against phosphorylated vimentin and GFAP

1996 • 25 citations

Phosphorylation of a 62-kd Porcine α-Internexin, a Newly Identified Intermediate Filament Protein

1993 • 23 citations