The cellular and molecular biology of keratins: beginning a new era

The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells

1982 • 5,272 citations

Dynamic instability of microtubule growth

1984 • 3,187 citations

The CpG dinucleotide and human genetic disease

1988 • 946 citations

Viscoelastic properties of vimentin compared with other filamentous biopolymer networks.

1991 • 694 citations

Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: Genetic and functional analyses

1991 • 647 citations

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

1990 • 642 citations

Revised clinical and laboratory criteria for subtypes of inherited epidermolysis bullosa

1991 • 511 citations

Biosynthesis of Human Papillomavirus from a Continuous Cell Line Upon Epithelial Differentiation

1992 • 448 citations

Epidermolysis Bullosa Simplex: Evidence in Two Families for Keratin Gene Abnormalities

1991 • 426 citations

Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease

1991 • 413 citations

A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering

1992 • 406 citations

Self-assembly of bovine epidermal keratin filaments in vitro

1976 • 388 citations

Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns.

1990 • 375 citations

Mutations in the Rod Domains of Keratins 1 and 10 in Epidermolytic Hyperkeratosis

1992 • 370 citations

The genetic basis of epidermolytic hyperkeratosis: A disorder of differentiation-specific epidermal keratin genes

1992 • 339 citations

Specific interaction between HPV-16 E1–E4 and cytokeratins results in collapse of the epithelial cell intermediate filament network

1991 • 327 citations

Two distinct classes of keratin genes and their evolutionary significance

1981 • 309 citations

A leucine→proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis

1992 • 284 citations

Cellular and Molecular Biology of Intermediate Filaments

1990 • 262 citations

Elucidating the early stages of keratin filament assembly.

1990 • 243 citations

The coiled coil of in vitro assembled keratin filaments is a heterodimer of type I and II keratins: use of site-specific mutagenesis and recombinant protein expression.

1990 • 239 citations

The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines.

1987 • 237 citations

Identification of a distinct soluble subunit of an intermediate filament protein: tetrameric vimentin from living cells.

1985 • 221 citations

Localization of Basement Membrane Components After Dermal-Epidermal Junction Separation

1983 • 211 citations

Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments.

1989 • 210 citations

The two-chain coiled-coil molecule of native epidermal keratin intermediate filaments is a type I-type II heterodimer.

1990 • 206 citations

A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases.

1991 • 202 citations

Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18.

1992 • 201 citations

Intermediate filament forming ability of desmin derivatives lacking either the amino-terminal 67 or the carboxy-terminal 27 residues

1985 • 193 citations

Production of human papillomavirus and modulation of the infectious program in epithelial raft cultures. OFF.

1992 • 188 citations

Glycosylation of nuclear and cytoplasmic proteins is ubiquitous and dynamic

1992 • 183 citations

The Molecular Biology of Intermediate Filament Proteins

1992 • 177 citations

Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit.

1990 • 173 citations

Retrovirus-mediated transgenic keratin expression in cultured fibroblasts: Specific domain functions in keratin stabilization and filament formation

1990 • 165 citations

Steady state dynamics of intermediate filament networks.

1992 • 162 citations

Cultured Cells for the Treatment of Disease

1991 • 158 citations

Do the ends justify the mean? Proline mutations at the ends of the keratin coiled-coil rod segment are more disruptive than internal mutations.

1992 • 152 citations

Protein complexes of intermediate-sized filaments: melting of cytokeratin complexes in urea reveals different polypeptide separation characteristics.

1983 • 143 citations

Intermediate filament dynamics

1992 • 143 citations

Assembly-disassembly of the nuclear lamina

1992 • 136 citations

Of mice and men: Genetic skin diseases of keratin

1992 • 135 citations

Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro.

1990 • 135 citations

Role of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein.

1990 • 132 citations

The role of the head and tail domain in lamin structure and assembly: Analysis of bacterially expressed chicken Lamin A and truncated B2 lamins

1992 • 130 citations

Characterization of human cytokeratin 2, an Epidermal cytoskeletal protein synthesized late during differentiation

1992 • 129 citations

The roles of K5 and K14 head, tail, and R/K L L E G E domains in keratin filament assembly in vitro.

1992 • 127 citations

Dynamic aspects of intermediate filament networks in BHK-21 cells.

1989 • 125 citations

Unifying principles in intermediate filament (IF) structure and assembly

1988 • 124 citations

Disease severity correlates with position of keratin point mutations in patients with epidermolysis bullosa simplex.

1993 • 122 citations

An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes.

1987 • 121 citations

Intermediate filaments formed de novo from tail-less cytokeratins in the cytoplasm and in the nucleus.

1991 • 114 citations

Intermediate filament-associated proteins

1991 • 112 citations

Molecular genetics of epidermolysis bullosa

1992 • 110 citations

Modulation of keratin intermediate filament assembly by single amino acid exchanges in the consensus sequence at the C-terminal end of the rod domain

1991 • 109 citations

Genetically Induced Abnormalities of Epidermal Differentiation and Ultrastructure in Ichthyoses and Epidermolyses: Pathogenesis, heterogeneity, Fetal Manifestation, and Prenatal Diagnosis

1983 • 101 citations

Keratin incorporation into intermediate filament networks is a rapid process.

1991 • 97 citations

Chemical cross‐linking indicates a staggered and antiparallel protofilament of desmin intermediate filaments and characterizes one higher‐level complex between protofilaments

1992 • 95 citations

PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.

1992 • 94 citations

Cytokeratin phosphorylation, cytokeratin filament severing and the solubilization of the maternal mRNA Vg1.

1991 • 92 citations

Assembly of amino-terminally deleted desmin in vimentin-free cells.

1990 • 91 citations

Epidermal growth factor-induced selective phosphorylation of cultured rat hepatocyte 55-kD cytokeratin before filament reorganization and DNA synthesis.

1989 • 85 citations

Phosphorylation of keratin intermediate filaments by protein kinase C, by calmodulin‐dependent protein kinase and by cAMP‐dependent protein kinase

1991 • 84 citations

Polarized and functional epithelia can form after the targeted inactivation of both mouse keratin 8 alleles.

1991 • 81 citations

Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops.

1992 • 79 citations

Coiled coil formation and sequence regularities in the helical regions of α-keratin

1978 • 79 citations

Analysis of the mechanism of assembly of mouse keratin 1/keratin 10 intermediate filaments in vitro suggests that intermediate filaments are built from multiple oligomeric units rather than a unique tetrameric building block

1991 • 73 citations

Assembly of vimentin in cultured cells varies with cell type

1989 • 68 citations

Keratin filament disruption in interphase and mitotic cells--how is it induced?

1987 • 67 citations

Polymorphic Keratins in Human Epidermis

1987 • 64 citations

Cytokeratin 13 Contains O-Glycosidically Linked N-Acetylglucosamine Residues

1989 • 63 citations

Tailless keratins assemble into regular intermediate filaments in vitro

1990 • 62 citations

A synthetic peptide representing the consensus sequence motif at the carboxy-terminal end of the rod domain inhibits intermediate filament assembly and disassembles preformed filaments.

1992 • 61 citations

A potential role for the COOH-terminal domain in the lateral packing of type III intermediate filaments.

1991 • 58 citations

Salt-stable interaction of the amino-terminal head region of vimentin with the α-helical rod domain of cytoplasmic intermediate filament proteins and its relevance to protofilament structure and filament formation and stability

1992 • 51 citations

Interference in vimentin assembly in vitro by synthetic peptides derived from the vimentin head domain

1992 • 51 citations

Intermediate filament molecular biology

1992 • 48 citations

Properties of the desmin tail domain: studies using synthetic peptides and antipeptide antibodies.

1990 • 41 citations

Identification and characterization of rat intestinal keratins. Molecular cloning of cDNAs encoding cytokeratins 8, 19, and a new 49-kDa type I cytokeratin (cytokeratin 21) expressed by differentiated intestinal epithelial cells

1991 • 33 citations

Phorbol acetate enhances the phosphorylation of cytokeratins 8 and 18 in human colonic epithelial cells

1991 • 32 citations

Modulation of keratin intermediate filament distribution in vivo by induced changes in cyclic AMP-dependent phosphorylation

1990 • 27 citations

Primary and Secondary Structure of IF Protein Chains and Modes of Molecular Aggregation

1990 • 20 citations