Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults.

Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies

1986 • 1,158 citations

Insulin-Like Growth Factors

1997 • 897 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

Human bone cellsin vitro

1985 • 696 citations

Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I.

1993 • 543 citations

Development and characterization of a conditionally immortalized human fetal osteoblastic cell line

1995 • 485 citations

Synthesis and Secretion of Insulin-like Growth Factor II by a Leiomyosarcoma with Associated Hypoglycemia

1988 • 346 citations

Sequence of a cDNA clone encoding human preproinsulin-like growth factor II

1984 • 326 citations

Two insulin-like growth factor I messenger RNAs are expressed in human liver.

1986 • 260 citations

Potentiation of insulin-like growth factor (IGF) action by IGF-binding protein-3: studies of underlying mechanism.

1992 • 228 citations

Increased Activity of Insulin-Like Growth Factor (IGF) in Osteoblastic Cells in the Presence of Growth Hormone (GH): Positive Correlation with the Presence of the GHInduced IGF-Binding Protein BP-3

1990 • 216 citations

Variables Controlling the Secretion of Insulin-Like Growth Factor Binding Protein-2 in Normal Human Subjects*

1991 • 213 citations

Effects of recombinant insulin-like growth factor-I and growth hormone on bone turnover in elderly women

1995 • 178 citations

Short-term effects of recombinant human insulin-like growth factor I on bone turnover in normal women.

1993 • 171 citations

Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?

1992 • 168 citations

Serum Somatomedin Levels in Adults with Chronic Renal Failure: TheImportance of Measuring Insulin-Like Growth Factor I (IGF-I) and IGF-II in Acid-Chromatographed Uremic Serum∗

1986 • 168 citations

Insulin-like Growth Factors in Health and Disease

1992 • 164 citations

Binding of insulin-like growth factor (IGF) I or II to IGF-binding protein-2 enables it to bind to heparin and extracellular matrix.

1996 • 139 citations

Intact but not truncated insulin-like growth factor binding protein-3 (IGFBP-3) blocks IGF I-induced stimulation of osteoblasts: Control of IGF signalling to bone cells by IGFBP-3-specific proteolysis?

1991 • 123 citations

Benefit of systemically administered rhIGF-I and rhIGF-I/IGFBP-3 on cancellous bone in ovariectomized rats

1994 • 115 citations

Human bone cells in vitro.

1985 • 111 citations

Basal and regulated secretion of insulin-like growth factor binding proteins in osteoblast-like cells is cell line specific.

1992 • 104 citations

Effects of prostaglandin E2 on bone formation in cultured fetal rat calvariae: role of insulin-like growth factor-I.

1993 • 100 citations

Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 proteinase in normal human osteoblast-like cells: Implications in bone cell physiology

1994 • 93 citations

Recombinant human [Cys281]insulin-like growth factor-binding protein 2 inhibits both basal and insulin-like growth factor I-stimulated proliferation and collagen synthesis in fetal rat calvariae.

1991 • 92 citations

Insulin-like growth factors

1996 • 92 citations

Purification and Characterization of a Unique High Molecular Weight Form of Insulin-Like Growth Factor II

1987 • 90 citations

A unique receptor-independent mechanism by which insulinlike growth factor I regulates the availability of insulinlike growth factor binding proteins in normal and transformed human fibroblasts.

1991 • 75 citations

Short-term effects of recombinant human insulin-like growth factor I on bone turnover in normal women

1993 • 71 citations

Potentiation of insulin-like growth factor (IGF) action by IGF-binding protein-3: studies of underlying mechanism

1992 • 62 citations

The Role of Insulin-Like Growth Factors and Their Binding Proteins in Tumor Hypoglycemia

1996 • 57 citations

Insulin-like growth factor-I serum concentrations and patterns of insulin-like growth factor binding proteins in patients with chronic liver disease

1996 • 54 citations

Basal and regulated secretion of insulin-like growth factor binding proteins in osteoblast-like cells is cell line specific

1992 • 50 citations

The effects of recombinant human insulin-like growth factor (rhIGF)-1 and rhIGF-1/IGF binding protein-3 administration on rat osteopenia induced by ovariectomy with concomitant bilateral sciatic neurectomy

1995 • 47 citations

Painful diffuse osteosclerosis after intravenous drug abuse

1992 • 46 citations

Doubling skeletal mass during adult life: The syndrome of diffuse osteosclerosis after intravenous drug abuse

1996 • 43 citations

Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors.

1996 • 39 citations

Hepatitis C-Associated Osteosclerosis: Late Onset after Blood Transfusion in an Elderly Woman

1998 • 34 citations

Acquired osteosclerosis associated with intravenous drug use and hepatitis C infection

1996 • 32 citations

Hepatitis C-Associated Osteosclerosis: An Unusual Syndrome of Acquired Osteosclerosis in Adults

1997 • 32 citations

Characterization of the high molecular weight insulin-like growth factor complex in term pregnancy serum.

1992 • 30 citations

Biophysical and Biological Properties of Naturally Occurring High Molecular Weight Insulin-like Growth Factor II Variants

1997 • 30 citations

Modulation of the Effects of Glucocorticoids on Collagen Synthesis in Fetal Rat Calvariae by Insulin-like Growth Factor Binding Protein-2

1997 • 29 citations

Binding of insulin-like growth factor (IGF) I or II to IGF-binding protein-2 enables it to bind to heparin and extracellular matrix

1996 • 28 citations

Characterization of proinsulin-like growth factor-II E-region immunoreactivity in serum and other biological fluids.

1993 • 25 citations

Case report: Idiopathic acquired diffuse osteosclerosis in a young woman

1990 • 24 citations

Hepatitis C-Associated Osteosclerosis After Blood Transfusion

1997 • 22 citations

Serumkonzentrationen der insulinähnlichen Wachstumsfaktoren (IGF)-I und IGF-II sowie der IGF Bindungsproteine (IGFBP)-2 und IGFBP-3 bei 49 Kindern mit ALL, NHL oder soliden Tumoren

1995 • 21 citations

The Role of Insulin-like Growth Factors and Binding Proteins in Bone Cell Biology

2002 • 13 citations

Immunoreactive proinsulin-like growth factor-II levels in healthy subjects, patients with growth hormone deficiency, and patients with type 1 diabetes: effects of insulin-like growth factor-I and insulin.

1994 • 13 citations

Influence of insulin-like growth factor-binding protein-2 on plasma clearance and transfer of insulin-like growth factors-I and -II from plasma into mammary-derived lymph and milk of goats

1996 • 13 citations

Stone Bone Syndrome—Diffuse Sclerosis of Bone: A Newly Described Clinical Disorder

1996 • 12 citations

Hepatitis C-Associated Osteosclerosis: Late Onset after Blood Transfusion in an Elderly Woman

1998 • 12 citations

Characterization of the high molecular weight insulin-like growth factor complex in term pregnancy serum

1992 • 11 citations

Characterization of proinsulin-like growth factor-II E-region immunoreactivity in serum and other biological fluids

1993 • 8 citations

Osteosclerosis in Intravenous Drug Abusers

1995 • 7 citations

Insulin-Like Growth Factors

2015 • 5 citations

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