The effects of recombinant human insulin-like growth factor (rhIGF)-1 and rhIGF-1/IGF binding protein-3 administration on rat osteopenia induced by ovariectomy with concomitant bilateral sciatic neurectomy

Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.

1983 • 1,535 citations

Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)

1991 • 680 citations

Insulin-Like Growth Factor I Has Independent Effects on Bone Matrix Formation and Cell Replication*

1988 • 606 citations

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

1989 • 541 citations

Bone Growth Factors

2001 • 483 citations

Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria.

1980 • 387 citations

Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: a potential local regulator of IGF action.

1989 • 358 citations

Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action.

1992 • 351 citations

Parathyroid Hormone Enhances the Transcript and Polypeptide Levels of Insulin-Like Growth Factor I in Osteoblast-Enriched Cultures from Fetal Rat Bone*

1989 • 337 citations

Insulin-Like Growth Factor I (IGF-I)-Binding Protein Complex Is a Better Mitogen than Free IGF-I*

1989 • 318 citations

Bone Growth Factors

1991 • 303 citations

Insulin-like growth factor-I supports formation and activation of osteoclasts.

1992 • 245 citations

In vivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats

1991 • 220 citations

Increased Activity of Insulin-Like Growth Factor (IGF) in Osteoblastic Cells in the Presence of Growth Hormone (GH): Positive Correlation with the Presence of the GHInduced IGF-Binding Protein BP-3

1990 • 216 citations

Cortisol Inhibits the Synthesis of Insulin-Like Growth Factor-I in Skeletal Cells*

1990 • 201 citations

Parathyroid Hormone Stimulates Release of Insulin-Like Growth Factor-I (IGF-I) and IGF-II from Neonatal Mouse Calvaria in Organ Culture*

1989 • 187 citations

Insulin-Like Growth Factors I and II: Aging and Bone Density in Women*

1984 • 178 citations

Low plasma levels of insulin‐like growth factor 1 (IGF‐1) in male patients with idiopathic osteoporosis

1992 • 175 citations

Short-term effects of recombinant human insulin-like growth factor I on bone turnover in normal women.

1993 • 171 citations

Insulin like growth factor I hormonal regulation by growth hormone and by 1,25(OH)2D3 and activity on human osteoblast-like cells in short-term cultures

1990 • 141 citations

Estradiol Regulation of Insulin-Like Growth Factor-I Expression in Osteoblastic Cells: Evidence for Transcriptional Control

1991 • 138 citations

Estradiol stimulates invitro the secretion of insulin-like growth factors by the clonal osteoblastic cell line, UMR106

1989 • 138 citations

Contrasting effects of parathyroid hormone and insulin-like growth factor I in an aged ovariectomized rat model of postmenopausal osteoporosis

1992 • 120 citations

Growth hormone-dependent insulin-like growth factor binding protein is a major determinant of bone mineral density in healthy men

1994 • 116 citations

Benefit of systemically administered rhIGF-I and rhIGF-I/IGFBP-3 on cancellous bone in ovariectomized rats

1994 • 115 citations

Insulin-like growth factor binding proteins in bone cell regulation.

1993 • 114 citations

Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3

1994 • 105 citations

Effects of tiludronate on bone mass, structure, and turnover at the epiphyseal, primary, and secondary spongiosa in the proximal tibia of growing rats after sciatic neurectomy

1994 • 103 citations

A novel synthetic vitamin D analogue, 2?-(3-hydroxypropoxy)1?, 25-dihydroxyvitamin D3 (ED-71), increases bone mass by stimulating the bone formation in normal and ovariectomized rats

1994 • 89 citations

Opposite effects of insulin-like growth factor-I on the formation of trabecular and cortical bone in adult female rats.

1992 • 85 citations

Osteoclast formation together with interleukin-6 production in mouse long bones is increased by insulin-like growth factor-I

1992 • 79 citations

Tartrate-resistant acid ATPase as a cytochemical marker for osteoclasts.

1989 • 75 citations

1,25-Dihydroxyvitamin D₃[1,25-(OH)₂D₃] Increases Insulin-Like Growth Factor I (IGF-I) Receptors in Clonal Osteoblastic Cells. Study on Interaction of IGF-I and 1,25-(OH)₂D₃*

1990 • 72 citations

Skeletal unloading induces resistance to insulin-like growth factor I

1994 • 70 citations

Parathyroid Hormone and Parathyroid Hormone-Related Peptide Stimulate Insulin-Like Growth Factor-Binding Protein Secretion by Rat Osteoblast-Like Cells through a Adenosine 3′,5′-Monophosphate-Dependent Mechanism*

1991 • 70 citations

The effects of tamoxifen on the osteopenia induced by sciatic neurotomy in the rat: A histomorphometric study

1988 • 57 citations

Further Characterization of Insulin-Like-Growth Factor Binding Proteins in Rat Osteoblast-Like Cell Cultures: Modulation by 17β-Estradiol and Human Growth Hormone

1991 • 50 citations

Mechanical loading modifies ovariectomy-induced cancellous bone loss

1994 • 40 citations

Properties of glycosylated and non-glycosylated human recombinant IGF binding protein-3 (IGFBP-3).

1993 • 37 citations

Systemic administration of rhIGF-I or rhIGF-I/IGFBP-3 increases cortical bone and lean body mass in ovariectomized rats

1995 • 37 citations

Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats

1993 • 33 citations

Effect of Estrogen on Immobilization Osteoporosis in Rat

1971 • 22 citations

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