Disruption of muscle architecture and myocardial degeneration in mice lacking desmin.

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Intermediate filaments as mechanical integrators of cellular space

1980 • 1,973 citations

INTERMEDIATE FILAMENTS: Structure, Dynamics, Function and Disease

1994 • 1,408 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: Genetic and functional analyses

1991 • 647 citations

Mice lacking vimentin develop and reproduce without an obvious phenotype

1994 • 603 citations

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

1993 • 550 citations

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis

1993 • 549 citations

MITOSIS AND INTERMEDIATE-SIZED FILAMENTS IN DEVELOPING SKELETAL MUSCLE

1968 • 509 citations

Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

1995 • 464 citations

Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration

1995 • 440 citations

Epidermolysis Bullosa Simplex: Evidence in Two Families for Keratin Gene Abnormalities

1991 • 426 citations

Immunological characterization of the subunit of the 100 A filaments from muscle cells.

1976 • 419 citations

Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease

1991 • 413 citations

A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering

1992 • 406 citations

MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle, and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes.

1990 • 393 citations

Deficient Cerebellar Long-Term Depression, Impaired Eyeblink Conditioning, and Normal Motor Coordination in GFAP Mutant Mice

1996 • 392 citations

Mutations in the Rod Domains of Keratins 1 and 10 in Epidermolytic Hyperkeratosis

1992 • 370 citations

The genetic basis of epidermolytic hyperkeratosis: A disorder of differentiation-specific epidermal keratin genes

1992 • 339 citations

Desmin and vimentin coexist at the periphery of the myofibril Z disc

1979 • 327 citations

Cardiovascular Lesions and Skeletal Myopathy in Mice Lacking Desmin

1996 • 327 citations

The synthesis and distribution of desmin and vimentin during myogenesis in vitro

1980 • 312 citations

Transient expression of the intermediate filament nestin during skeletal muscle development

1993 • 290 citations

A leucine→proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis

1992 • 284 citations

The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14.

1995 • 263 citations

Intermediate filaments in disease

1995 • 248 citations

Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK)

1994 • 244 citations

Redistribution of intermediate filament subunits during skeletal myogenesis and maturation in vitro.

1979 • 242 citations

Synemin: a new high molecular weight protein associated with desmin and vimentin filaments in muscle

1980 • 234 citations

The riddle of morphogenesis: A question of solution chemistry or molecular cell engineering?

1993 • 219 citations

Immunoelectron microscopic studies of desmin (skeletin) localization and intermediate filament organization in chicken cardiac muscle.

1983 • 210 citations

Replicating myoblasts express a muscle-specific phenotype.

1988 • 206 citations

Distribution of vimentin and desmin filaments in smooth muscle tissue of mammalian and avian aorta

1982 • 203 citations

A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases.

1991 • 202 citations

The existence of an insoluble Z disc scaffold in chicken skeletal muscle

1978 • 192 citations

Molecular and cell biology of skeletal muscle regeneration

1993 • 189 citations

On the possible role of cytoskeletal filamentous networks in intracellular signaling: An approach based on percolation

1995 • 181 citations

A functional "knockout" of human keratin 14.

1994 • 176 citations

Myogenic Regulatory Factors: Dissecting Their Role and Regulation during Vertebrate Embryogenesis

1993 • 164 citations

Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin

1994 • 161 citations

The cytoskeletal lattice of muscle cells

1992 • 156 citations

Distributions of vimentin and desmin in developing chick myotubes in vivo. I. Immunofluorescence study.

1984 • 153 citations

Intermediate filaments in cardiac myogenesis: nestin in the developing mouse heart.

1995 • 147 citations

Titin and myosin, but not desmin, are linked during myofibrillogenesis in postmitotic mononucleated myoblasts.

1986 • 142 citations

Sequential appearance of muscle‐specific proteins in myoblasts as a function of time after cell division: Evidence for a conserved myoblast differentiation program in skeletal muscle

1994 • 139 citations

Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation.

1989 • 139 citations

Intermediate filaments and disease: mutations that cripple cell strength.

1994 • 132 citations

Myogenesis and the Intermediate Filament Protein, Nestin

1994 • 130 citations

A Single MEF2 Site Governs Desmin Transcription in Both Heart and Skeletal Muscle during Mouse Embryogenesis

1996 • 130 citations

Desmin is present in proliferating rat muscle satellite cells but not in bovine muscle satellite cells

1991 • 124 citations

Cytoskeletal Control of Myogenesis: A Desmin Null Mutation Blocks the Myogenic Pathway during Embryonic Stem Cell Differentiation

1995 • 119 citations

Somite subdomains, muscle cell origins, and the four muscle regulatory factor proteins.

1994 • 117 citations

Desmin myopathy: a multisystem disorder involving skeletal, cardiac, and smooth muscle

1995 • 114 citations

Epidermolytic palmoplantar keratoderma cosegregates with a keratin 9 mutation in a pedigree with breast and ovarian cancer

1994 • 111 citations

Intermediate-size Filaments: Changes in Synthesis and Distribution in Cells of the Myogenic and Neurogenic Lineages

1982 • 111 citations

Regulation of the mouse desmin gene: transactivation by MyoD, myogenin, MRF4 and Myf5

1993 • 104 citations

Intermediate filaments: new proteins, some answers, more questions

1995 • 102 citations

Goblin (ankyrin) in striated muscle: identification of the potential membrane receptor for erythroid spectrin in muscle cells.

1984 • 100 citations

Immunocytochemical analysis of intermediate filaments in embryonic heart cells with monoclonal antibodies to desmin.

1984 • 99 citations

Desmin/vimentin intermediate filaments are dispensable for many aspects of myogenesis.

1991 • 96 citations

An E box in the desmin promoter cooperates with the E box and MEF-2 sites of a distal enhancer to direct muscle-specific transcription.

1994 • 96 citations

Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis.

1996 • 94 citations

Autosomal dominant distal myopathy with desmin storage: A clinicopathologic and electrophysiologic study of a large kinship

1994 • 92 citations

Expression of intermediate filament-associated proteins paranemin and synemin in chicken development.

1983 • 86 citations

Mutations in the non-helical linker segment L1-2 of keratin 5 in patients with Weber-Cockayne epidermolysis bullosa simplex

1994 • 76 citations

Intermediate Filament Proteins: Cytoskeletal Elements with Gene-Regulatory Function?

1994 • 74 citations

The distribution of intermediate filament protein (skeletin) in normal and diseased human skeletal muscle

1980 • 74 citations

Immunoelectron and immunofluorescence localization of desmin in mature avian muscles.

1981 • 70 citations

Trans-cellular Desmin-Lamin B Intermediate Filament Network in Cardiac Myocytes

1993 • 66 citations

Expression of intermediate filament proteins during development of Xenopus laevis: II. Identification and molecular characterization of desmin

1989 • 62 citations

Characterization and regulation in the expression of a gene coding for the intermediate filament protein desmin.

1984 • 61 citations

Intermediate Filament and Associated Proteins in Heart Purkinje Fibers: A Membrane‐Myofibril Anchored Cytoskeletal System^a

1985 • 59 citations

Familial desminopathy: myopathy with accumulation of desmin-type intermediate filaments.

1993 • 54 citations

Desmin pathology in neuromuscular diseases

1993 • 45 citations

Integration of Intermediate Filaments into Cellular Organelles

1996 • 43 citations

Synemin Contains the Rod Domain of Intermediate Filaments

1995 • 42 citations

Intermediate filaments and lipoprotein cholesterol

1994 • 39 citations

Disruption of intermediate filament organization leads to structural defects at the intersomite junction in Xenopus myotomal muscle

1995 • 36 citations

Developmental regulation of intermediate filament and actin mRNAs during myogenesis is disrupted by oncogenic ras genes.

1989 • 35 citations

Desmin expression during early mouse tongue morphogenesis.

1992 • 34 citations

Site‐specific antibodies block kinase a phosphorylation of desmin in vitro and inhibit incorporation of myoblasts into myotubes

1991 • 23 citations

A New 220, 000 Dalton Protein Located in the Z Lines of Vertebrate Skeletal Muscle1

1981 • 21 citations

The role of Myf-5 in somitogenesis and the development of skeletal muscles in vertebrates

1993 • 15 citations