The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

High-resolution crystal structure of cytochrome P450cam

1987 • 1,396 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

The computer program LUDI: A new method for the de novo design of enzyme inhibitors

1992 • 821 citations

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

1992 • 605 citations

Biochemistry and molecular biology of the human CYP2C subfamily

1994 • 534 citations

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

1994 • 500 citations

Evidence That CYP2C19 is the Major (S)-Mephenytoin 4'-Hydroxylase in Humans

1994 • 366 citations

Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver

1993 • 258 citations

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

1991 • 255 citations

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.

1990 • 236 citations

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

1990 • 218 citations

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9

1991 • 208 citations

Speculations on the Substrate Structure-Activity Relationship (SSAR) of cytochrome P450 enzymes

1992 • 203 citations

Tolbutamide hydroxylation by human liver microsomes

1988 • 198 citations

Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: Inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

1994 • 168 citations

Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9.

1994 • 163 citations

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

1992 • 152 citations

Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies

1993 • 143 citations

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

1989 • 134 citations

Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

1993 • 132 citations

The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

1986 • 130 citations

Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling.

1985 • 124 citations

Expression of Modified Cytochrome P450 2C10 (2C9) in Escherichia coli, Purification, and Reconstitution of Catalytic Activity

1993 • 116 citations

Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes.

1991 • 111 citations

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1988 • 106 citations

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.

1991 • 98 citations

The stereochemical basis of anticonvulsant drug action. I. The crystal and molecular structure of diphenylhydantoin, a noncentrosymmetric structure solved by centric symbolic addition

1971 • 96 citations

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1987 • 91 citations

Human hepatic microsomal metabolism of delta 1-tetrahydrocannabinol.

1992 • 91 citations

Human‐liver cytochromes P‐450 expressed in yeast as tools for reactive‐metabolite formation studies

1993 • 90 citations

A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation

1991 • 89 citations

Role of Protic and Dipolar Aprotic Solvents in Heterocyclic Syntheses via 1,3-Dipolar Cycloaddition Reactions

1973 • 88 citations

A major role for cytochrome P450TB (CYP2C subfamily) in the actions of non-steroidal antiinflammatory drugs.

1993 • 81 citations

In vitro oxidation of oxicam NSAIDs by a human liver cytochrome P450

1992 • 61 citations

[14] Expression of mammalian cytochrome P450 enzymes using yeast-based vectors

1991 • 54 citations

The crystal and molecular structure and absolute configuration of (−)-(S)-warfarin

1975 • 50 citations

Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system.

1989 • 46 citations

Metabolic hydroxylation of the thiophene ring: Isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat

1984 • 41 citations

Cytochrome P450 2C9 is responsible for hydroxylation of the naphthoquinone antimalarial drug 58C80 in human liver

1993 • 39 citations

The structure of the orthorhombic form of tolbutamide (1-n-butyl-3-p-toluenesulphonylurea)

1981 • 28 citations

Pharmacokinetic study of 2,3-dichloro 4- (2-thienyl keto14C) phenoxyacetic acid (tienilic acid) in animals

1977 • 23 citations

Chemical and statistical considerations in the determination of partition coefficients of weakly ionizable drugs and poisons

1984 • 11 citations

Application of a Second-Order Derivtive Spectroscopic Technique: Determination of the Ionization Constants of Phenytoin and Phenobarbital

1989 • 7 citations

Human Liver Mephenytoin 4 -Hydroxylase Cytochrome P-450 Proteins and Genes

1989 • 6 citations

Synthese d'un diuretique marque au carbone 14: Acide dichloro‐2,3 [thenoyl‐2 (¹⁴C = 0)]‐4 phenoxy acetique (D.C.I. acide tiénilique)

1976 • 5 citations

Acide [dichloro-2,3(thénoyl-2)-4 phénoxy]acétique (acide tiénilique)

1980 • 3 citations

Deleted Work

1955 • 0 citations