[14] Expression of mammalian cytochrome P450 enzymes using yeast-based vectors

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Transformation of yeast by a replicating hybrid plasmid

1978 • 1,362 citations

Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis

1982 • 422 citations

Compilation and comparison of the sequence context around the AUG startcodons inSaccharomyces cerevisiaemRNAs

1987 • 334 citations

Secretion cloning vectors in Escherichia coli.

1984 • 322 citations

Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis

1989 • 261 citations

Expression of Rat Liver Cytochrome P-450MC cDNA inSaccharomyces cerevisiae

1985 • 221 citations

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

1990 • 218 citations

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

1990 • 207 citations

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

1989 • 134 citations

Synthesis of functional mouse cytochromes P-450 P1 and chimeric P-450 P3-1 in the yeast Saccharomyces cerevisiae

1988 • 132 citations

A Genetically Engineered P450 Monooxygenase: Construction of the Functional Fused Enzyme between Rat Cytochrome P450c and NADPH-Cytochrome P450 Reductase

1987 • 107 citations

cDNA cloning and functional expression in yeast Saccharomyces cerevisiae of β‐naphthoflavone‐induced rabbit liver P‐450 LM4 and LM6

1988 • 101 citations

Expression of human liver cytochrome P450 IIIA4 in yeast

1990 • 91 citations

Characterization of the alkane-inducible cytochrome P450 (P450alk) gene from the yeast Candida tropicalis: identification of a new P450 gene family

1989 • 91 citations

Secondary structure determination for α‐neurotoxin from Dendroaspis polylepis polylepis based on sequence‐specific ¹H‐nuclear‐magnetic‐resonance assignments

1988 • 86 citations

Site-directed mutageneses of rat liver cytochrome P-450d: axial ligand and heme incorporation

1988 • 83 citations

Expression of a functional 78,000 dalton mammalian flavoprotein, NADPH-cytochrome P-450 oxidoreductase, in Escherichia coli

1987 • 74 citations

Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (ω-1)-hydroxylase and testosterone 16α-hydroxylase)

1989 • 72 citations

Expression of Rat NADPH-Cytochrome P-450 Reductase cDNA inSaccharomyces cerevisiae

1986 • 72 citations

Genetically Engineered P450 Monooxygenases: Construction of Bovine P450c17/Yeast Reductase Fused Enzymes

1990 • 63 citations

Expression inSaccharomyces cerevisiaeof Chimeric Cytochrome P450 cDNAs Constructed from cDNAs for Rat Cytochrome P450c and P450d

1987 • 58 citations

Expression of Bovine Cytochrome P450c17 cDNA inSaccharomyces cerevisiae

1989 • 49 citations

Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system.

1989 • 46 citations

Characterization of Rat Cytochrome P-450MC Synthesized in Saccharomyces cerevisiae1

1985 • 45 citations

The importance of threonine‐301 from cytochromes P‐450 (laurate (ω‐1)‐hydroxylase and testosterone 16α‐hydroxylase) in substrate binding as demonstrated by site‐directed mutagenesis

1988 • 44 citations

Cytochromes P-450 of yeasts.

1986 • 43 citations

Characterization of Rabbit Liver Cytochrome P-450 (Laurate ω-1 Hydroxylase) Synthesized in Transformed Yeast Cells1

1988 • 38 citations

Cytochrome P-450 Related to P-4504 from Phenobarbital-Treated Rabbit Liver: Molecular Cloning of cDNA and Characterization of Cytochrome P-450 Obtained by Its Expression in Yeast Cells1

1987 • 33 citations

Expression of cytochrome P-450_dbySaccharomyces cerevisiae

1986 • 25 citations

Expression of Alcohol-Inducible Rabbit Liver Cytochrome P-450 3a (P-450IIE1) inSaccharomyces cerevisiaewith the Copper-Inducible CUP1 Promoter

1990 • 25 citations

Monooxygenase Activity of Saccharomyces cerevisiae Cells Transformed with Expression Plasmids Carrying Rat Cytochrome P-450MC cDNA1

1986 • 23 citations

Bindings of axial ligands to cytochrome P-450d mutants: a difference absorption spectral study

1989 • 20 citations