The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes

1983 • 192 citations

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

1984 • 185 citations

Defective Oxidation of Drugs

1982 • 182 citations

Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution

1982 • 145 citations

Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation

1983 • 123 citations

The genetic controlof bufuralol metabolisminman

1982 • 76 citations

Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme.

1984 • 68 citations

Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism) — Increased michaelis constant (km) and loss of stereoselectivity of bufuralol 1′-hydroxylation in poor metabolizers

1984 • 66 citations

Genetic polymorphism in drug oxidation: In vitro studies of human debrisoquine 4-hydroxylase and bufuralol 1′-hydroxylase activities

1985 • 65 citations

Isolation and sequence of a human cytochrome P-450 cDNA clone.

1985 • 59 citations

Debrisoquine‐type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation

1984 • 55 citations

Oxidation of sparteines by cytochrome P-450: evidence against the formation of N-oxides

1984 • 49 citations

Inter-ethnic difference in sparteine oxidation among Ghanaians and Germans

1985 • 44 citations

Bufuralol metabolism in human liver: a sensitive probe for the debrisoquine‐type polymorphism of drug oxidation

1984 • 40 citations

Steric configuration and polymorphic oxidation of lipophilic beta-adrenoceptor blocking agents: in vivo — in vitro correlations

1985 • 30 citations

The genetic defect of mephenytoin hydroxylation

1986 • 27 citations

Electrical responses to taste chemicals across the dorsal epithelium of bullfrog tongue

1985 • 16 citations