Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins

1985 • 1,253 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

1991 • 1,092 citations

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

1992 • 605 citations

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

1989 • 382 citations

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

1990 • 218 citations

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9

1991 • 208 citations

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1991 • 200 citations

Tolbutamide hydroxylation by human liver microsomes

1988 • 198 citations

Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8

1989 • 181 citations

Rat liver UDP-glucuronosyltransferase. Sequence and expression of a cDNA encoding a phenobarbital-inducible form.

1986 • 171 citations

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

1989 • 134 citations

Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes.

1991 • 111 citations

Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers

1990 • 107 citations

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1988 • 106 citations

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.

1991 • 98 citations

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1987 • 91 citations

Mechanisms of inhibition of tolbutamide metabolism: Phenylbutazone, oxyphenbutazone, sulfaphenazole

1977 • 87 citations

A molecular model for the enzyme cytochrome P45017α, a major target for the chemotherapy of prostatic cancer

1990 • 85 citations

Sequence requirements for cytochrome P-450IIB1 catalytic activity

1989 • 80 citations

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10.

1988 • 80 citations

The Effect of Different Sulfonamides on Phenytoin Metabolism in Man

1979 • 64 citations

Sequence requirements for cytochrome P-450IID1 catalytic activity. A single amino acid change (Ile380 Phe) specifically decreases Vmax of the enzyme for bufuralol but not debrisoquine hydroxylation.

1990 • 63 citations

cDNA and amino acid sequences of two members of the human P450IIC gene subfamily

1987 • 58 citations

Nucleotide Sequence of a Human Liver Cytochrome P-450 Related to the Rat Male Specific Form1

1987 • 53 citations

Phenytoin: Pharmacogenetic polymorphism of 4′-hydroxylation

1990 • 34 citations

Phenytoin 4-hydroxylation by rabbit liver P450IIC3 and identification of orthologs in human liver microsomes

1990 • 29 citations

Cytochrome P-450 human-2 (P-450IIC9) in Mephenytoin Hydroxylation Polymorphism in Human Livers: Differences in Substrate and Stereoselectivities among Microheterogeneous P-450IIC Species Expressed in Yeasts1

1991 • 24 citations

The Effect of Different Oral Anticoagulants on Diphenylhydantoin (DPH) and Tolbutamide Metabolism

1976 • 22 citations

Genetic factors influencing the metabolism of tolbutamide

1989 • 21 citations

Immunohistochemical localization and quantitation of NADPH-cytochrome P-450 reductase in human liver.

1987 • 18 citations