Human‐liver cytochromes P‐450 expressed in yeast as tools for reactive‐metabolite formation studies

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

1987 • 320 citations

[7] Purification and properties of NADPH-Cytochrome P-450 reductase

1978 • 303 citations

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

1991 • 255 citations

Expression of Rat Liver Cytochrome P-450MC cDNA inSaccharomyces cerevisiae

1985 • 221 citations

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

1990 • 218 citations

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9

1991 • 208 citations

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1991 • 200 citations

Tolbutamide hydroxylation by human liver microsomes

1988 • 198 citations

Cytochrome P-450 Monooxygenase Activities in Human and Rat Liver Microsomes

1981 • 173 citations

A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis.

1984 • 166 citations

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

1989 • 134 citations

Maximizing the expression of mammalian cytochrome P-450 monooxygenase activities in yeast cells

1990 • 110 citations

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1988 • 106 citations

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.

1991 • 98 citations

Studies on the Microsomal Electron-transport System of Anaerobically Grown Yeast

1974 • 93 citations

Thiophene S-oxides as new reactive metabolites: formation by cytochrome P-450 dependent oxidation and reaction with nucleophiles

1991 • 92 citations

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1987 • 91 citations

Expression of human liver cytochrome P450 IIIA4 in yeast

1990 • 91 citations

Anti-liver microsomes autoantibodies and dihydralazine-induced hepatitis: specificity of autoantibodies and inductive capacity of the drug.

1992 • 83 citations

Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes

1991 • 71 citations

Basic Science in Toxicology

1990 • 68 citations

Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency

1987 • 60 citations

Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin.

1984 • 58 citations

Engineered yeast cells as model to study coupling between human xenobiotic metabolizing enzymes

1993 • 57 citations

[14] Expression of mammalian cytochrome P450 enzymes using yeast-based vectors

1991 • 54 citations

Oxidative activation of the thiophene ring by hepatic enzymes

1990 • 48 citations

Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system.

1989 • 46 citations

Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA.

1991 • 43 citations

Hydroxylation of the thiophene ring by hepatic monooxygenases

1990 • 32 citations

Detection of human hepatitis anti-liver kidney microsomes (LKM2) autoantibodies on rat liver sections is predominantly due to reactivity with rat liver P-450 IIC11.

1991 • 26 citations

Cytochrome P-450 human-2 (P-450IIC9) in Mephenytoin Hydroxylation Polymorphism in Human Livers: Differences in Substrate and Stereoselectivities among Microheterogeneous P-450IIC Species Expressed in Yeasts1

1991 • 24 citations

Human Liver Mephenytoin 4 -Hydroxylase Cytochrome P-450 Proteins and Genes

1989 • 6 citations

Chemostat studies of microsomal enzyme induction in Saccharomyces cerevisiae

1991 • 6 citations

Cytochromes p-450 et activation metabolique du noyau thiophene : exemple de l'acide tienilique et de ses derives

1992 • 1 citations

Deleted Work

1955 • 0 citations

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