Results of a phase III, double-blind, placebo-controlled trial of megestrol acetate modulation of P-glycoprotein-mediated drug resistance in the first-line management of small-cell lung carcinoma

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.

1987 • 343 citations

Controlled Trial of Megestrol Acetate for the Treatment of Cancer Anorexia and Cachexia

1990 • 320 citations

A controlled trial of megestrol acetate on appetite, caloric intake, nutritional status, and other symptoms in patients with advanced cancer

1990 • 238 citations

Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line

1987 • 205 citations

Function and Regulation of the Human Multidrug Resistance Gene

1992 • 186 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.

1990 • 157 citations

A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. A southwest oncology group study

1995 • 155 citations

Randomized double-blind placebo-controlled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensive-stage small-cell lung cancer: a North Central Cancer Treatment Group study.

1996 • 141 citations

Approaches to the analysis of quality of life data: experiences gained from a Medical Research Council Lung Cancer Working Party palliative chemotherapy trial

1994 • 120 citations

Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein

1989 • 107 citations

Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled randomized trial.

1994 • 101 citations

High-dose megestrol acetate. A possible treatment for cachexia.

1987 • 100 citations

Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study

1993 • 88 citations

Characterization of an etoposide-resistant human small-cell lung cancer cell line

1990 • 68 citations

A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer

1993 • 66 citations

Megestrol acetate reverses multidrug resistance and interacts with P-glycoprotein

1992 • 61 citations

Enhanced cytotoxicity against colon carcinoma by combinations of noncompeting monoclonal antibodies to the 17-1A antigen.

1988 • 53 citations

Amplification and expression of mdr1 gene in a multidrug resistant variant of small cell lung cancer cell line NCI-H69

1989 • 52 citations

Multidrug Resistance in the Laboratory and Clinic

1994 • 52 citations

High-dose megestrol acetate. A possible treatment for cachexia

1987 • 24 citations

MDR1 gene expression in lung cancer

1990 • 8 citations

Approaches to the analysis of quality of life data: Experiences gained from a medical research council lung cancer working party palliative chemotherapy trial

1995 • 7 citations

Randomized double-blind placebo-controlled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensive-stage small-cell lung cancer: A North Central Cancer Treatment Group study

1996 • 6 citations

Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study

1994 • 4 citations