Back to search

Omega-3 Fatty Acids and the Regulation of Expression of Endothelial Pro-Atherogenic and Pro-Inflammatory Genes

Data up to Jan 2025

Published2005
Citations128
References132

Total Citations Per Year

Abstract

References (132)

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial

1999 • 3,818 citations

Matrix Metalloproteinases

1999 • 3,774 citations

Coronary Plaque Disruption

1995 • 3,542 citations

A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis

1995 • 3,361 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease

1985 • 2,210 citations

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.

1999 • 2,021 citations

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

2002 • 1,963 citations

The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

1989 • 1,951 citations

Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.

1994 • 1,913 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?

1978 • 1,689 citations

Leukotrienes and Other Products of the 5-Lipoxygenase Pathway

1990 • 1,216 citations

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

2001 • 1,153 citations

Activation mechanisms of matrix metalloproteinases.

1997 • 1,134 citations

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

2003 • 1,052 citations

The Composition of Food Consumed by Greenland Eskimos

1976 • 964 citations

Coxibs and Cardiovascular Disease

2004 • 897 citations

Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974.

1980 • 865 citations

Hypothesis: Vasa Vasorum and Neovascularization of Human Coronary Arteries

1984 • 852 citations

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

1999 • 830 citations

Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial

2003 • 738 citations

Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture.

1995 • 723 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis.

1993 • 709 citations

Epidemiological Studies in the Upernavik District, Greenland

1980 • 691 citations

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

1995 • 691 citations

Evidence for Increased Collagenolysis by Interstitial Collagenases-1 and -3 in Vulnerable Human Atheromatous Plaques

1999 • 660 citations

Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.

1994 • 644 citations

Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion

2003 • 613 citations

Failing the Public Health — Rofecoxib, Merck, and the FDA

2004 • 598 citations

Neovascular Expression of E-Selectin, Intercellular Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Human Atherosclerosis and Their Relation to Intimal Leukocyte Content

1996 • 573 citations

Pregnancy-Associated Plasma Protein A as a Marker of Acute Coronary Syndromes

2001 • 565 citations

Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases.

1995 • 556 citations

Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids

2003 • 534 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.

1993 • 525 citations

Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids

2003 • 501 citations

The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells.

1994 • 467 citations

COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice

2004 • 413 citations

Cyclooxygenase isozymes and their gene structures and expression

2002 • 412 citations

Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.

1994 • 408 citations

Augmented Expression of Cyclooxygenase-2 in Human Atherosclerotic Lesions

1999 • 379 citations

Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.

1996 • 359 citations

Angiogenesis and the atherosclerotic carotid plaque: An association between symptomatology and plaque morphology

1999 • 354 citations

Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E 2 -Dependent Plaque Instability

2001 • 349 citations

Post-transcriptional Control of Cyclooxygenase-2 Gene Expression

2000 • 342 citations

Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid

1979 • 318 citations

Eicosapolyenoic acids of serum lipids of Japanese islanders with low incidence of cardiovascular diseases.

1982 • 303 citations

Intimal vascularisation and atherosclerosis

1951 • 299 citations

Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro

1993 • 296 citations

Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2.

1993 • 293 citations

Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice

2002 • 280 citations

Membrane Type 1 Matrix Metalloproteinase Expression in Human Atherosclerotic Plaques

1999 • 279 citations

DNA Methylation and Silencing of Gene Expression

2000 • 276 citations

Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway

1998 • 275 citations

Vascular endothelial groth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: Conversion of prothrombin to thrombin results in progelatininase a activation and cell proliferation

1998 • 274 citations

Enhanced Expression of Vascular Matrix Metalloproteinases Induced In Vitro by Cytokines and in Regions of Human Atherosclerotic Lesionsa

1994 • 272 citations

Cyclooxygenase 2 is a key enzyme for inflammatory cytokine‐induced angiogenesis

2004 • 267 citations

Intimal Neovascularization in Human Coronary Atherosclerosis : Its Origin and Pathophysiological Significance

1995 • 265 citations

The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent.

1994 • 250 citations

n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE 2 induced ERK-1 and -2 and HIF-1α induction pathway

2004 • 247 citations

Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease

2001 • 232 citations

Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice

2001 • 217 citations

Oleic Acid Inhibits Endothelial Activation

1999 • 217 citations

Neutrophil Elastase in Human Atherosclerotic Plaques

2003 • 215 citations

Inflammatory Cytokines and Oxidized Low Density Lipoproteins Increase Endothelial Cell Expression of Membrane Type 1-Matrix Metalloproteinase

1999 • 211 citations

Immunohistochemical study of intimal microvessels in coronary atherosclerosis.

1993 • 203 citations

Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain

2004 • 193 citations

Docosahexaenoic Acid Selectively Attenuates Induction of Vascular Cell Adhesion Molecule–1 and Subsequent Monocytic Cell Adhesion to Human Endothelial Cells Stimulated by Tumor Necrosis Factor–α

1995 • 187 citations

The Biology of Arteriosclerosis

1938 • 176 citations

DNA supercoiling: Another level for regulating gene expression

1981 • 166 citations

Role of Nuclear Factor-κB Activation in Metalloproteinase-1, -3, and -9 Secretion by Human Macrophages In Vitro and Rabbit Foam Cells Produced In Vivo

2002 • 165 citations

In Situ Localization and Quantification of mRNA for 92-kD Type IV Collagenase and Its Inhibitor in Aneurysmal, Occlusive, and Normal Aorta

1995 • 161 citations

Matrix metalloproteinases, inflammation and atherosclerosis: therapeutic perspectives

2004 • 160 citations

Extracellular Proteases in Atherosclerosis and Restenosis

2005 • 158 citations

Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms

2004 • 157 citations

Expression of Stromelysin-3 in Atherosclerotic Lesions: Regulation via CD40–CD40 Ligand Signaling In Vitro and In Vivo

1999 • 153 citations

Atherosclerosis in Alaska Natives and non-natives

1993 • 144 citations

Vascular prostacyclin is increased in patients ingesting omega-3 polyunsaturated fatty acids before coronary artery bypass graft surgery.

1990 • 141 citations

Nutritional mechanisms that influence cardiovascular disease

2006 • 141 citations

Eicosapentaenoic acid and prostacyclin production by cultured human endothelial cells.

1983 • 133 citations

Effect of omega-3 fatty acids on the progression of metastases after the surgical excision of human breast cancer cell solid tumors growing in nude mice.

1996 • 126 citations

Uptake, release and metabolism of docosahexaenoic acid (DHA, C22:6ω3) in human platelets and neutrophils

1984 • 123 citations

How the host ‘sees’ pathogens: global gene expression responses to infection

2000 • 119 citations

Structural requirements for inhibition of cytokine-induced endothelial activation by unsaturated fatty acids

1998 • 110 citations

Cardiovascular deaths among Alaskan Natives, 1980-86.

1990 • 110 citations

Evolutionary adaptation to different thermal environments via transcriptional regulation.

1992 • 108 citations

Positive supercoiling of DNA greatly diminishes mRNA synthesis in yeast.

1992 • 105 citations

Omega-3 fatty acids and endothelial leukocyte adhesion molecules

1995 • 105 citations

Ischaemia-induced and reperfusion-induced arrhythmias differ in their sensitivity to potassium: Implications for mechanisms of initiation and maintenance of ventricular fibrillation

1989 • 105 citations

NADPH Oxidase in Endothelial Cells: Impact on Atherosclerosis

2003 • 102 citations

Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice

2005 • 100 citations

Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and -9 in fetal rat hepatocytes

2001 • 98 citations

Antiangiogenicity of docosahexaenoic acid and its role in the suppression of breast cancer cell growth in nude mice.

1999 • 96 citations

Cytokine‐mediated induction of cyclo‐oxygenase‐2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide

1995 • 92 citations

Effects of Reduced Dietary Linoleic Acid Intake, Alone or Combined With an Algal Source of Docosahexaenoic Acid, on MDA-MB-231 Breast Cancer Cell Growth and Apoptosis in Nude Mice

1999 • 91 citations

Inhibitory effects of oleic and docosahexaenoic acids on lung metastasis by colon-carcinoma-26 cells are associated with reduced matrix metalloproteinase-2 and -9 activities

1997 • 91 citations

The roles of adhesion molecules and proteinases in lymphocyte transendothelial migration

1996 • 89 citations

Regulation of bacterial gene expression by metal–protein complexes

1990 • 88 citations

Docosapentaenoic acid (22:5, n-3) suppressed tube-forming activity in endothelial cells induced by vascular endothelial growth factor

2003 • 86 citations

Expression of Cyclo-oxygenase-2 in Human Atherosclerotic Carotid Arteries

2000 • 86 citations

Effects of MF-tricyclic, a selective cyclooxygenase-2 inhibitor, on atherosclerosis progression and susceptibility to cytomegalovirus replication in apolipoprotein-E knockout mice

2003 • 82 citations

The Metzincin-Superfamily of Zinc-Peptidases

1996 • 79 citations

Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production

2001 • 74 citations

Effect of Cholera Toxin and Pertussis Toxin on Prostaglandin-H Synthase-2, Prostaglandin E2, and Matrix Metalloproteinase Production by Human Monocytes

1994 • 68 citations

Eicosapentaenoic acid attenuates vascular endothelial growth factor-induced proliferation via inhibiting Flk-1 receptor expression in bovine carotid artery endothelial cells

1998 • 65 citations

Eicosapentaenoic acid inhibits tube formation of vascular endothelial cellsin vitro

1991 • 64 citations

Chronic inhibition of cyclooxygenase-2 does not alter plaque composition in a mouse model of advanced unstable atherosclerosis

2003 • 63 citations

Ionizing Radiation Stimulates Mitochondrial Gene Expression and Activity

1998 • 60 citations

Role of the hemA gene product and delta-aminolevulinic acid in regulation of Escherichia coli heme synthesis

1997 • 58 citations

Raising the Safety Bar — The FDA's Coxib Meeting

2005 • 58 citations

Increased expression of disintegrin‐metalloproteinases ADAM‐15 and ADAM‐9 following upregulation of integrins α5β1 and αvβ3 in atherosclerosis

2003 • 58 citations

Signaling Mechanism Underlying COX-2 Induction by Lysophosphatidylcholine

2001 • 58 citations

Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions

2000 • 57 citations

n‐3 fatty acids: Antiatherosclerotic effects

2001 • 54 citations

Cause of death in 339 Alaskan natives as determined by autopsy.

1970 • 52 citations

Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression

2003 • 47 citations

Turnover of mRNA in prokaryotes and lower eukaryotes

1992 • 39 citations

Angiogenesis and Its Regulation: Roles of Vascular Endothelial Cell Growth Factor

2000 • 38 citations

Plaque Angiogenesis: Its Functions and Regulation

2002 • 35 citations

Eicosapentanoic acid inhibits hypoxia-reoxygenation-induced injury by attenuating upregulation of MMP-1 in adult rat myocytes

2003 • 31 citations

The role of chromatin in transcriptional regulation

1997 • 31 citations

Nutrients and Gene Expression

2004 • 30 citations

mRNA export: the long and winding road

2000 • 30 citations

Inhibition by eicosapentaenoic acid of IL-1β-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway

2003 • 29 citations

DE1, a 12-Base Pair cis-Regulatory Element Sufficient to Confer Dark-inducible and Light Down-regulated Expression to a Minimal Promoter in Pea

2000 • 29 citations

Comparative Study of Vanadate- and Phorbol Ester-induced Cyclo-oxygenase-2 Expression in Human Endothelial Cells

1999 • 19 citations

Differential effects of long chain n-3 fatty acids on the expression of PGH synthase isoforms in bovine aortic endothelial cells

1999 • 17 citations

Influence of Capping and Polyadenylation on mRNA Expression and on Antisense RNA Mediated Inhibition of Gene Expression

1997 • 9 citations

Nutrients and Gene Expression

2001 • 6 citations

Cited By (0)

Loading...