Post-transcriptional Control of Cyclooxygenase-2 Gene Expression

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

1998 • 1,139 citations

Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the invivo stability of ARE-containing mRNAs

1998 • 852 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein

1998 • 738 citations

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1997 • 734 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Cloning and Characterization of HuR, a Ubiquitously Expressed Elav-like Protein

1996 • 652 citations

Altered eicosanoid levels in human colon cancer.

1993 • 571 citations

Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1.

1993 • 533 citations

Identification of an AUUUA-Specific Messenger RNA Binding Protein

1989 • 515 citations

Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.

1990 • 495 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors

1996 • 438 citations

Control of mRNA Decay by Heat Shock-Ubiquitin-Proteasome Pathway

1999 • 395 citations

Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs.

1993 • 356 citations

Modulation of the Fate of Cytoplasmic mRNA by AU-Rich Elements: Key Sequence Features Controlling mRNA Deadenylation and Decay

1997 • 352 citations

Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences

1989 • 347 citations

Glyceraldehyde-3-phosphate Dehydrogenase Selectively Binds AU-rich RNA in the NAD+-binding Region (Rossmann Fold)

1995 • 345 citations

Rapid Cytoplasmic Turnover of c-myc mRNA: Requirement of the 3′ Untranslated Sequences

1987 • 302 citations

Peroxisome Proliferators Enhance Cyclooxygenase-2 Expression in Epithelial Cells

1999 • 298 citations

The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors.

1991 • 297 citations

Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2.

1993 • 293 citations

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.

1991 • 293 citations

mRNA Decay Mediated by Two Distinct AU-Rich Elements from c-fos and Granulocyte-Macrophage Colony-Stimulating Factor Transcripts: Different Deadenylation Kinetics and Uncoupling from Translation

1995 • 276 citations

A 32-kilodalton protein binds to AU-rich domains in the 3' untranslated regions of rapidly degraded mRNAs.

1991 • 268 citations

Identification of TIAR as a Protein Binding to the Translational Regulatory AU-rich Element of Tumor Necrosis Factor α mRNA

1999 • 256 citations

Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation

1996 • 235 citations

Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases.

1989 • 235 citations

GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor

1988 • 227 citations

Serum and Glucocorticoid Regulation of Gene Transcription and Expression of the Prostaglandin H Synthase-1 and Prostaglandin H Synthase-2 Isozymes

1993 • 224 citations

The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs.

1991 • 222 citations

Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences.

1993 • 208 citations

v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.

1994 • 207 citations

Repression of Cyclooxygenase-2 and Prostaglandin E2Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA

1998 • 203 citations

Self-Promotion? Intimate Connections Between APC and Prostaglandin H Synthase-2

1996 • 203 citations

Induction of Cyclooxygenase-2 by Activated Ha-rasOncogene in Rat-1 Fibroblasts and the Role of Mitogen-activated Protein Kinase Pathway

1998 • 193 citations

The cyclic AMP response element plays an essential role in the expression of the human prostaglandin‐endoperoxide synthase 2 gene in differentiated U937 monocytic cells

1994 • 185 citations

Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences.

1987 • 182 citations

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.

1992 • 181 citations

The 3' untranslated region of the human interferon-beta mRNA has an inhibitory effect on translation.

1987 • 177 citations

Regulation of c-myc mRNA Stability In Vitro by a Labile Destabilizer with an Essential Nucleic Acid Component

1989 • 172 citations

Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions.

1990 • 163 citations

Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation.

1994 • 147 citations

Prostaglandin G/H Synthase Isoenzyme 2 Expression in Fibroblasts - Regulation by Dexamethasone, Mitogens, and Oncogenes

1993 • 134 citations

Selective Destabilization of Short-Lived mRNAs with the Granulocyte-Macrophage Colony-Stimulating Factor AU-Rich 3' Noncoding Region Is Mediated by a Cotranslational Mechanism

1993 • 131 citations

Translation and the stability of mRNAs encoding the transferrin receptor and c-fos.

1991 • 127 citations

AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity.

1995 • 126 citations

Regulation of c-myc mRNA stability in vitro by a labile destabilizer with an essential nucleic acid component.

1989 • 82 citations

Rapid Degradation of AU-Rich Element (ARE) mRNAs Is Activated by Ribosome Transit and Blocked by Secondary Structure at Any Position 5′ to the ARE

1995 • 76 citations

AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm

1994 • 75 citations

Cytokine messenger RNA stability is enhanced in tumor cells

1991 • 65 citations

Modulation of granulocyte-macrophage colony-stimulating factor mRNA stability in vitro by the adenosine-uridine binding factor.

1994 • 64 citations

Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos.

1989 • 63 citations

A 3' truncation of MYC caused by chromosomal translocation in a human T-cell leukemia increases mRNA stability.

1990 • 63 citations

Turnover and Translation of in Vitro Synthesized Messenger RNAs in Transfected, Normal Cells

1996 • 61 citations

Identification of a translation inhibitory element (TIE) in the 3′ untranslated region of the human interferon-β mRNA

1988 • 59 citations

Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region is mediated by a cotranslational mechanism.

1993 • 59 citations

Alternate COX-2 Transcripts Are Differentially Regulated: Implications for Post-Transcriptional Control

1997 • 57 citations

Binding of sequence-specific proteins to the adenosine- plus uridine-rich sequences of the murine granulocyte/macrophage colony-stimulating factor mRNA.

1992 • 55 citations

Characterization of adenosine‐uridine‐rich RNA binding factors

1995 • 44 citations

Translational Control Mediated by UA-Rich Sequences

1990 • 42 citations

Purification of an AU-Rich RNA Binding Protein from Sarcophaga peregrina (Flesh Fly) and Its Identification as a Thiolase1

1993 • 39 citations

65‐kDa protein binds to destabilizing sequences in the IFN‐β mRNA coding and 3′ UTR

1993 • 33 citations

Association of AUUUA-binding Protein with A + U-rich mRNA during nucleo-cytoplasmic transport

1992 • 33 citations

The inducible prostaglandin biosynthetic enzyme, cyclooxygenase 2, is not mutated in patients with attenuated adenomatous polyposis coli.

1998 • 19 citations

DNase I Treatment of Total RNA Improves the Accuracy of Ribonuclease Protection Assay

1998 • 6 citations