Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis

2000 • 4,048 citations

Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis

2000 • 3,176 citations

CYCLOOXYGENASES 1 AND 2

1998 • 2,700 citations

Cyclooxygenase in biology and disease

1998 • 2,483 citations

Risk of Cardiovascular Events Associated With Selective COX-2 Inhibitors

2001 • 1,716 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

The Coxibs, Selective Inhibitors of Cyclooxygenase-2

2001 • 1,563 citations

Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4

2001 • 1,241 citations

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

1976 • 1,032 citations

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

2004 • 987 citations

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

1994 • 826 citations

Role of Prostacyclin in the Cardiovascular Response to Thromboxane A ₂

2002 • 771 citations

Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression.

1994 • 632 citations

27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells

2001 • 531 citations

COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease

2002 • 517 citations

Relationship Between Selective Cyclooxygenase-2 Inhibitors and Acute Myocardial Infarction in Older Adults

2004 • 512 citations

Prevention of Atherosclerosis in Apolipoprotein E-Deficient Mice by Bone Marrow Transplantation

1995 • 467 citations

Aspirin as a Therapeutic Agent in Cardiovascular Disease

1997 • 437 citations

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice.

1990 • 404 citations

Augmented Expression of Cyclooxygenase-2 in Human Atherosclerotic Lesions

1999 • 379 citations

Selective COX-2 Inhibition Improves Endothelial Function in Coronary Artery Disease

2003 • 362 citations

Cardiovascular Thrombotic Events in Controlled, Clinical Trials of Rofecoxib

2001 • 358 citations

Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E ₂ -Dependent Plaque Instability

2001 • 349 citations

Prostaglandin E2 Suppresses Chemokine Production in Human Macrophages through the EP4 Receptor

2002 • 333 citations

Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells

2003 • 312 citations

Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2.

1996 • 301 citations

Cyclooxygenase-2 Is Widely Expressed in Atherosclerotic Lesions Affecting Native and Transplanted Human Coronary Arteries and Colocalizes With Inducible Nitric Oxide Synthase and Nitrotyrosine Particularly in Macrophages

1999 • 294 citations

Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice

2002 • 280 citations

The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2−/−, but not in cyclooxygenase-1−/− mice

1999 • 269 citations

A Polymorphism in the Cyclooxygenase 2 Gene as an Inherited Protective Factor Against Myocardial Infarction and Stroke

2004 • 255 citations

CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2

2003 • 247 citations

Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo

1999 • 236 citations

Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice

2001 • 217 citations

Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H

1987 • 216 citations

Cyclooxygenases, Thromboxane, and Atherosclerosis

2005 • 192 citations

Cardiovascular thrombotic events in arthritis trials of the cyclooxygenase-2 inhibitor celecoxib**The investigators had full access to the data and complete control over the design, conduct analysis, interpretation, and description of the study. The sponsor of the study had no role in study design, data collection, data analysis, data interpretation, or in writing the report. The views expressed are those of the investigators alone.

2003 • 178 citations

Extracellular Matrix Modulates Macrophage Functions Characteristic to Atheroma

1998 • 161 citations

Macrophage Lipoprotein Lipase Promotes Foam Cell Formation and Atherosclerosis in Low Density Lipoprotein Receptor-deficient Mice

2000 • 152 citations

Suppression of the Functionally Coupled Cyclooxygenase-2/Prostaglandin E Synthase as a Basis of Simvastatin-Dependent Plaque Stabilization in Humans

2003 • 145 citations

Comparison of cardiovascular thrombotic events in patients with osteoarthritis treated with Rofecoxib versus nonselective nonsteroidal anti-inflammatory drugs (Ibuprofen, Diclofenac, and Nabumetone)

2002 • 144 citations

Loss of Lymphotoxin-α but Not Tumor Necrosis Factor-α Reduces Atherosclerosis in Mice

2002 • 140 citations

Regulation of Prostaglandin Biosynthesis by Nitric Oxide Is Revealed by Targeted Deletion of Inducible Nitric-oxide Synthase

2000 • 139 citations

HMG-CoA reductase inhibitors suppress maturation of human dendritic cells: new implications for atherosclerosis

2003 • 135 citations

Cyclooxygenase-2 and inflammation in atherosclerosis

2004 • 131 citations

Cyclooxygenase Isoforms and Platelet Vessel Wall Interactions in the Apolipoprotein E Knockout Mouse Model of Atherosclerosis

2003 • 124 citations

Cyclooxygenase-2 Expression and Inhibition in Atherothrombosis

2003 • 123 citations

Involvement of chemokine receptor 2 and its ligand, monocyte chemoattractant protein-1, in the development of atherosclerosis: lessons from knockout mice

2001 • 123 citations

Superparamagnetic Iron Oxide–Based Method for Quantifying Recruitment of Monocytes to Mouse Atherosclerotic Lesions In Vivo

2003 • 121 citations

Regulation of tumor necrosis factor-alpha and IL-1 beta synthesis by thromboxane A2 in nonadherent human monocytes.

1997 • 111 citations

Effects of MF-tricyclic, a selective cyclooxygenase-2 inhibitor, on atherosclerosis progression and susceptibility to cytomegalovirus replication in apolipoprotein-E knockout mice

2003 • 82 citations

Monocyte Membrane Type 1-Matrix Metalloproteinase

2001 • 79 citations

Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux

2001 • 73 citations

Chronic inhibition of cyclooxygenase-2 does not alter plaque composition in a mouse model of advanced unstable atherosclerosis

2003 • 63 citations

Celecoxib Reduces Skin Damage After Radiation

2003 • 59 citations

Antimitogenic effects of HDL and APOE mediated by Cox-2–dependent IP activation

2004 • 49 citations

Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient mice

2000 • 49 citations

No Effect of Cyclooxygenase Inhibition on Plaque Size in Atherosclerosis-prone Mice

2002 • 49 citations

Polymerase Chain Reaction–Based Method for Quantifying Recruitment of Monocytes to Mouse Atherosclerotic Lesions In Vivo

2000 • 47 citations

Exogenous but not endogenous prostanoids regulate cytokine secretion from murine bone marrow dendritic cells: EP2, DP, and IP but not EP1, EP3, and FP prostanoid receptors are involved

2003 • 45 citations

Oxidized Low Density Lipoprotein Suppresses Expression of Inducible Cyclooxygenase in Human Macrophages

1999 • 40 citations

NS-398 Treatment after Trauma Modifies NF-κB Activation and Improves Survival

2001 • 36 citations

Lesion progression and plaque composition are not altered in older apoE−/− mice lacking tumor necrosis factor-α receptor p55

2004 • 30 citations

Signal Transduction in Atherosclerosis: Second Messengers and Regulation of Cellular Cholesterol Trafficking

1995 • 18 citations