IGF-I in Neuronal Differentiation and Neuroprotection

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

The insulin signaling system.

1994 • 1,733 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Insulin-like growth factors and their binding proteins

1990 • 929 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Functional Interactions of Neurotrophins and Neurotrophin Receptors

1995 • 825 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Regulators of cell death

1995 • 647 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

Insulin-like growth factor I increases brain growth and central nervous system myelination in tTransgenic mice

1993 • 468 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS

1994 • 432 citations

Expression of Somatomedin/Insulin-Like Growth Factor Messenger Ribonucleic Acids in the Human Fetus: Identification, Characterization, and Tissue Distribution*

1988 • 375 citations

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

1992 • 370 citations

The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 366 citations

The cell-death machine

1996 • 351 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1991 • 337 citations

ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis

1996 • 327 citations

The Insulin-Like Growth Factor-I Receptor

1994 • 325 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

Cellular Pattern of Insulin-Like Growth Factor-I (IGF-I) and Type I IGF Receptor Gene Expression in Early Organogenesis: Comparison with IGF-II Gene Expression

1990 • 320 citations

Mechanisms of Apoptosis: Integration of Genetic, Biochemical, and Cellular Indicators

1994 • 320 citations

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

1996 • 314 citations

Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum.

1980 • 313 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Transient IGF-I gene expression during the maturation of functionally related central projection neurons

1991 • 287 citations

The genetic regulation of apoptosis

1995 • 283 citations

A system for characterizing cellular and molecular events in programmed neuronal cell death

1993 • 267 citations

Apoptosis: Molecular Control Point in Toxicity

1994 • 263 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice

1995 • 257 citations

Receptors for Insulin-like Growth Factors I and II: Autoradiographic Localization in Rat Brain and Comparison to Receptors for Insulin*

1988 • 252 citations

Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor.

1994 • 234 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis

1990 • 228 citations

Insulin-like Growth Factors (IGF) in Muscle Development

1989 • 228 citations

Progress in Brain Research

1995 • 226 citations

Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nerves

1986 • 223 citations

The Protooncogene bcl‐2 Inhibits Apoptosis in PC12 Cells

1993 • 222 citations

Quantitative autoradiographic localization of [¹²⁵I]insulin‐like growth factor I, [¹²⁵I]insulin‐like growth factor II, and [¹²⁵I]insulin receptor binding sites in developing and adult rat brain

1993 • 207 citations

Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and of higher molecular mass forms.

1985 • 205 citations

Effects of insulin, insulin-like growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells

1984 • 194 citations

Distinct roles of erythropoietin, insulin-like growth factor I, and stem cell factor in the development of erythroid progenitor cells.

1994 • 181 citations

Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I.

1992 • 180 citations

CrmA-inhibitable Cleavage of the 70-kDa Protein Component of the U1 Small Nuclear Ribonucleoprotein during Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 179 citations

Implication of insulin-like growth factors in the pathogenesis of diabetic neuropathy

1995 • 177 citations

Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain

1991 • 176 citations

Human neuroblastoma cells in culture: a model for neuronal cell differentiation and function.

1990 • 175 citations

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma.

1994 • 170 citations

Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death

1996 • 169 citations

Insulin‐like growth factor I stimulates oligodendrocyte development and myelination in rat brain aggregate cultures

1991 • 169 citations

Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I.

1986 • 166 citations

Two types of receptor for insulin-like growth factors in mammalian brain.

1985 • 163 citations

Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins

1996 • 162 citations

Insulin-like Growth Factor-I-mediated Neurite Outgrowth in Vitro Requires Mitogen-activated Protein Kinase Activation

1997 • 157 citations

Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain

1991 • 151 citations

Insulin-like growth factor-1 (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system

1989 • 148 citations

Tyrosine Phosphorylation of Paxillin and Focal Adhesion Kinase during Insulin-like Growth Factor-I-stimulated Lamellipodial Advance

1997 • 144 citations

Insulin-like growth factor I shifts from promoting cell division to potentiating maturation during neuronal differentiation.

1991 • 141 citations

Increased Expression of the Insulin-like Growth Factor-II Gene in Wilms' Tumor Is Not Dependent on Loss of Genomic Imprinting or Loss of Heterozygosity

1996 • 140 citations

Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development

1993 • 138 citations

Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: Correlation with insulin-like growth factors I and II

1993 • 133 citations

Role of insulin-like growth factors in peripheral nerve regeneration

1994 • 130 citations

Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.

1996 • 128 citations

Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization

1989 • 122 citations

Expression of IGF‐I and insulin receptor genes in the rat central nervous system: A developmental, regional, and cellular analysis

1991 • 121 citations

Evidence for an important role of IGF-I and IGF-II for the early development of chick sympathetic neurons

1995 • 119 citations

Ontogeny of Insulin-Like Growth Factors (IGF-I and IGF-II) and IGF-Binding Proteins in Porcine Serum during Fetal and Postnatal Development*

1991 • 112 citations

Insulin-like growth factor II increases the rate of sciatic nerve regeneration in rats

1993 • 111 citations

Insulin and insulinlike growth factor receptors regulating neurite formation in cultured human neuroblastoma cells

1988 • 106 citations

Stabilization of tubulin mRNAs by insulin and insulin-like growth factor I during neurite formation

1989 • 103 citations

Developmental Expression of the Tissue Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor in the Rat

1989 • 102 citations

Histochemical localization of IGF-I and IGF-II mRNA in the rat between birth and adulthood

1988 • 102 citations

Ontogeny of the porcine insulin-like growth factor system

1993 • 100 citations

Regulation of Oligodendrocyte Development and Central Nervous System Myelination by Insulin‐like Growth Factors^a

1993 • 97 citations

Peptide Growth Factors and Proto-oncogenes in Mammalian Conceptus Development1

1991 • 88 citations

Expression of Insulin-Like Growth Factor-I during Chicken Development*

1991 • 88 citations

Specific, temporally regulated expression of the insulin-like growth factor II gene during muscle cell differentiation.

1993 • 80 citations

Coordinate developmental regulation of high and low molecular weight mRNAs for rat insulin-like growth factor II.

1986 • 77 citations

Structural and functional analysis of insulin-like growth factors

1989 • 76 citations

Insulin-like growth factor-I influences the initiation of myelination: studies of the anterior commissure of transgenic mice

1995 • 69 citations

The expression of insulin-like growth factors and their binding proteins in normal human lymphocytes

1993 • 67 citations

Naturally occurring and axotomy-induced motoneuron death and its prevention by neurotrophic agents: a comparison between chick and mouse

1994 • 64 citations

Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells

1997 • 60 citations

Apoptosis of bcl-x-deficient telencephalic cells in vitro

1996 • 59 citations

Somatomedin levels in cerebrospinal fluid from adults with pituitary disorders

1984 • 58 citations

Basic fibroblast growth factor rescues CNS neurons from cell death caused by high oxygen atmosphere in culture

1992 • 57 citations

Insulin-like Growth Factors as Regulators of Cell Motility Signaling Mechanisms

1997 • 57 citations

The Trk Family of Tyrosine Kinases: Receptors for NGF-related Neurotrophins

1992 • 57 citations

Systemic administration of rhIGF-I enhanced regeneration after sciatic nerve crush in mice.

1995 • 55 citations

Immunohistochemical localization of insulin-like growth factor-II (IGF-II) and IGF-binding protein-2 during development in the rat brain.

1994 • 54 citations

Tyrosine Phosphorylation and Enhanced Expression of Paxillin during Neuronal Differentiation in Vitro

1996 • 52 citations

[Insulin like growth factor-I and II].

1999 • 47 citations

Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells.

1993 • 47 citations

Apoptosis: Breaking the ICE

1994 • 46 citations

Regulation of insulin‐like growth factor‐II expression and its role in autocrine growth of human neuroblastoma cells

1993 • 44 citations

Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins in the Developing Rhesus Monkey*

1991 • 44 citations

Expression of the insulin-like growth factor (IGF)-I and -II and the IGF-I and -II receptor genes during postnatal development of the rat ovary.

1992 • 37 citations

Effects of serum and insulin-like growth factors on human neuroblastoma cell growth

1993 • 36 citations

Growth Stimulation by Transfection of Intestinal Epithelial Cells with an Antisense Insulin-like Growth Factor-Binding Protein-2 Construct

1995 • 36 citations

Elevation of cytosolic calcium by cholinoceptor agonists in SH‐SY5Y human neuroblastoma cells: estimation of the contribution of voltage‐dependent currents

1992 • 35 citations

Gene expression of the insulin-like growth factors and their receptors in human neuroblastoma cell lines

1992 • 35 citations

Two types of high voltage-activated calcium channels in SH-SY5Y human neuroblastoma cells

1993 • 34 citations

Interferon‐γ inhibits DNA synthesis and insulin‐like growth factor‐II expression in human neuroblastoma cells

1993 • 34 citations

Developmental expression of rat insulin-like growth factor-II/mannose 6-phosphate receptor messenger ribonucleic acid.

1992 • 33 citations

Effect of insulin and insulin-like growth factor I on the expression of the catecholaminergic phenotype by neural crest cells

1992 • 31 citations

Mannose-6-Phosphate Enhances Cross-Linking Efficiency between Insulin-Like Growth Factor-II (IGF-II) and IGF-II/Mannose-6-Phosphate Receptors in Membranes*

1991 • 30 citations

The Potential of Insulin‐like Growth Factor‐I as a Therapeutic for the Treatment of Neuromuscular Disorders

1993 • 26 citations

Mitogenically Uncoupled Insulin and IGF-I Receptors of Differentiated Human Neuroblastoma Cells Are Functional and Mediate Ligand-Induced Signals

1990 • 25 citations

Mannose 6-phosphate potentiates insulin-like growth factor II effects in cultured human neuroblastoma cells

1991 • 24 citations

Immunohistochemical localization of insulin-like growth factor-II (IGF- II) and IGF-binding protein-2 during development in the rat brain

1994 • 23 citations

Specific, temporally regulated expression of the insulin-like growth factor II gene during muscle cell differentiation

1993 • 20 citations

Suramin disrupts insulin-like growth factor-II (IGF-II) mediated autocrine growth in human SH-SY5Y neuroblastoma cells

1997 • 18 citations

Developmental expression of rat insulin-like growth factor-II/mannose 6- phosphate receptor messenger ribonucleic acid

1992 • 17 citations

Single transient potassium channels in human neuroblastoma cells induced to differentiate in vitro

1988 • 17 citations

Laminin Promotes Differentiation, Adhesion and Proliferation of Cell Cultures Derived from Human Acoustic Nerve Schwannoma

1995 • 16 citations

Second Messengers Mediating Gene Expression Essential to Neurite Formation Directed by Insulin and Insulin-Like Growth Factors

1991 • 16 citations

Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells

1993 • 12 citations

On the Therapeutic Potential for Insulin-like Growth Factor Use in Motor Neuron Disease

1993 • 9 citations

The tyrosine kinase inhibitor methyl 2,5-dihydroxycinnimate disrupts changes in the actin cytoskeleton required for neurite formation

1996 • 6 citations