Suppression of Vascular Endothelial Growth Factor-Mediated Endothelial Cell Protection by Survivin Targeting

The biochemistry of apoptosis

2000 • 7,314 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Control of apoptosis and mitotic spindle checkpoint by survivin

1998 • 1,881 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

1998 • 1,243 citations

Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

1998 • 996 citations

Dysregulation of Apoptosis in Cancer

1999 • 983 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

1998 • 643 citations

Vascular Endothelial Growth Factor (VEGF)-Mediated Angiogenesis Is Associated with Enhanced Endothelial Cell Survival and Induction of Bcl-2 Expression

1999 • 638 citations

Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway

2000 • 633 citations

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

1999 • 613 citations

Regulation of apoptosis at cell division by p34 ^cdc2 phosphorylation of survivin

2000 • 606 citations

Akt Mediates Cytoprotection of Endothelial Cells by Vascular Endothelial Growth Factor in an Anchorage-dependent Manner

1999 • 557 citations

A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy.

2000 • 491 citations

Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor vascuiature induced by TNF and IFN-γ

1998 • 461 citations

Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.

1999 • 418 citations

Vascular Endothelial Growth Factor–Stimulated Actin Reorganization and Migration of Endothelial Cells Is Regulated via the Serine/Threonine Kinase Akt

2000 • 413 citations

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

1998 • 376 citations

Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma

1999 • 371 citations

2′-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells

1997 • 366 citations

Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells

2000 • 347 citations

Marked Induction of the IAP Family Antiapoptotic Proteins Survivin and XIAP by VEGF in Vascular Endothelial Cells

1999 • 342 citations

Survivin apoptosis: an interloper between cell death and cell proliferation in cancer.

1999 • 284 citations

Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis

1998 • 266 citations

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

1999 • 251 citations

Protective genes expressed in endothelial cells: a regulatory response to injury

1997 • 222 citations

Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis

1999 • 222 citations

Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth

2000 • 205 citations

Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division

1999 • 194 citations

The Role of Antiapoptotic Bcl-2 Family Members in Endothelial Apoptosis Elucidated with Antisense Oligonucleotides

1999 • 110 citations

Vitronectin decreases microvascular endothelial cell apoptosis

1998 • 67 citations

Modulation of Endothelial Cell Apoptosis : Mechanisms and Pathophysiological Roles

1996 • 64 citations